Detection of C-Peptide in Urine as a Measure of Ongoing Beta Cell Function

McDonald, Timothy J.; Perry, Mandy H

doi:10.1007/7651_2016_330

Cited by 7 publications

(2 citation statements)

References 43 publications

(47 reference statements)

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“…Recent studies have shown that UCPCR is a useful alternative to blood CP and 24-h UCP tests, and can better reflect the function of the islet. Other tests have some limitations such as the instability of blood CP and the difficulty in 24-h UCP sample retention, but UCPCR sample can be stored for at least 3 days at room temperature with the addition of boric acid preservative ( 21 ). The experiment adopted in this paper has little interference from proteinuria and naked eye hematuria, and has stable performance and high stability.…”

Section: Discussionmentioning

confidence: 99%

Application of urine C-peptide creatinine ratio in type 2 diabetic patients with different levels of renal function

Zhou

Li²,

Yuan³

et al. 2022

Front. Endocrinol.

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ObjectiveThis study aims to investigate the effect of single urine C peptide/creatinine (UCPCR) in assessing the islet β Cell function of type 2 diabetes mellitus (T2DM) patients with different renal function.MethodsA total of 85 T2DM patients were recruited in this study, all the patients were assigned to one group with estimated glomerular filtration rate (eGFR)≤60 ml·min-1·1.73 m-2 and another group complicated with eGFR>60 ml·min-1·1.73 m-2. Serum creatinine, urine creatinine, serum fasting C-peptide (FCP), fasting blood glucose (FBG), glycosylated hemoglobin (HbA1C) and 24-hour urinary C-peptide (24hUCP) were measured. The modified homeostasis model assessment-islet β cell function [HOMA-islet (CP-DM)], the modified homeostasis model assessment-insulin resistance [HOMA-IR(CP)] and UCPCR were calculated.ResultsWhen compared with group eGFR ≤60 ml·min-1·1.73 m-2, the levels of UCPCR, FCP, the modified HOMA-IR(CP) and HOMA-islet (CP-DM) were promoted and the concentrations of HbA1C, FPG, creatinine were decreased in the patients of eGFR>60 ml·min-1·1.73 m-2 (P<0.05); FCP was uncorrelated with 24hUCP while associated with UCPCR in the patients of eGFR ≤ 60 ml·min-1·1.73 m-2; UCPCR was positively correlated with FCP and HOMA-IR(CP) in the T2DM patients with different levels of renal function; the cut-off (UCPCR ≤ 1.13 nmol/g) had 88.37% sensitivity and 95.24% specificity [95% confidence interval (CI):0.919-0.997] for identifying severe insulin deficiency in T2DM patients[area under the curve (AUC) 0.978].ConclusionUCPCR can be used to evaluate islets β Cell function in T2DM patients with different renal function status.

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Section: Discussionmentioning

confidence: 99%

Application of urine C-peptide creatinine ratio in type 2 diabetic patients with different levels of renal function

Zhou

Li²,

Yuan³

et al. 2022

Front. Endocrinol.

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show abstract

“…Urine C-peptide measurement is a less invasive and practical alternative to serum C-peptide measurements (5). Furthermore, Urinary C-peptide to creatinine ratio (UCPCR) is a surrogate marker for endogenous insulin secretion (7).…”

Section: Introduction Backgroundmentioning

confidence: 99%

Stimulated UCPCR Levels Are Lower in People With Type 1 Diabetes Than in Other Diabetes Types in Sub-Saharan Africa: Results From a Preliminary Cross-Sectional Study

Katte

Morfaw-Kibula

Agoons³

et al. 2022

Front. Public Health

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BackgroundThe clinical utility of Urinary C-Peptide to Creatinine Ratio (UCPCR) is well understood in people with different types of diabetes in Caucasian populations, but studies are lacking in African populations. We, therefore, aimed to examine Urinary C-Peptide to Creatinine Ratio levels among groups of people with different types of diabetes in a sub-Saharan African population.MethodsA total of 47 adults with diabetes; 10 with type 1 diabetes, 26 with type 2 diabetes, 11 with ketosis-prone diabetes, and 22 healthy control individuals, were recruited from Yaoundé Central Hospital in Cameroon. Fasting blood glucose and C-peptide were measured in venous blood and urine. Stimulated Urinary C-Peptide to Creatinine Ratio was determined in all subjects after ingestion of a standardized mixed meal. We compared the stimulated Urinary C-peptide to Creatinine Ration concentration in subjects with type 1 diabetes to the other groups.ResultsThe basal C-peptide and HOMA-β were lower in T1D than in the T2D group [median 57 (34, 69) vs. 398 (335, 502) pmol/l; p ≤ 0.001] and [median 3.0 (1.63, 5.25) vs. 30.6 (17.94, 45.03); p < 0.001] respectively. Also, basal C-peptide and HOMA-β were lower in T1D than in those with KPD [median 57 (34, 69) vs. 330 (265, 478) pmol/l; p = 0.003] and [median 3.0 (1.63, 5.25) vs. 47.1 (16.2, 63.1), p = 0.001] respectively. Basal C-peptide was not different between participants with T2D and KPD; 398 (335, 502) vs. 330 (265, 478) pmol/l, p = 0.19. Stimulated UCPCR was lower in T1D compared to T2D, KPD and control participants; [median 0.29 (0.14, 0.68) vs. 0.89 (0.40, 1.69) nmol/moll; p = 0.009], [median 0.29 (0.14, 0.68) vs. 1.33 (0.84, 1.59) nmol/mol; p = 0.006] and [median 0.29 (0.14, 0.68) vs. 1.21 (0.85, 1.21) nmol/mol; p = 0.005] respectively. However, stimulated UCPCR was similar between the T2D and KPD study participants; 0.89 (0.40, 1.69) vs. 1.33 (0.84, 1.59) nmol/mol, p = 0.36.ConclusionsStimulated Urinary C-Peptide to Creatinine Ratio (UCPCR) is lower in participants with type 1 diabetes compared to those with other types of diabetes in this population. This means stimulated UCPCR could potentially differentiate type 1 diabetes from other diabetes types among people with diabetes in sub-Saharan Africa.

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Peptide Antibodies in Clinical Laboratory Diagnostics

Trier

2017

Advances in Clinical Chemistry

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Detection of C-Peptide in Urine as a Measure of Ongoing Beta Cell Function

Cited by 7 publications

References 43 publications

Application of urine C-peptide creatinine ratio in type 2 diabetic patients with different levels of renal function

Application of urine C-peptide creatinine ratio in type 2 diabetic patients with different levels of renal function

Stimulated UCPCR Levels Are Lower in People With Type 1 Diabetes Than in Other Diabetes Types in Sub-Saharan Africa: Results From a Preliminary Cross-Sectional Study

Peptide Antibodies in Clinical Laboratory Diagnostics

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