Detection of breast cancer using non-invasive X-ray diffraction technique of hair: A preliminary study

Abstract

Background: An early diagnosis of breast cancer relates directly to an accurate treatment plan and strategy. Early detec on of breast cancer before its development would be a significant reduc on of morbidity and mortality rates. The aim of this preliminary study is to inves gate the sensi vity of Wide Angle X-ray diffrac on (WAXRD) method on women hair samples of healthy and breast cancer pa ents in comparison with other modali es such as synchrotron based XRD beam and mammography. Materials and Methods: Hair samples were taken from occipital region of skull from healthy and breast cancer pa ents (43 women) were analyzed using X-ray diffrac on and the results were analyzed and compared with mammography and pathology reports. Results: The results of analyzed samples showed the sensi vity for purposed WAXRD method was 86% in comparison with synchrotron based XRD beam (64%) and also with mammography (70%). Conclusion: This non-invasive method is less harmful and is more sensi ve than the two other methods and help the physicians for choosing accurate treatment plan.

Emerging Diagnostic and Therapeutic Potentials of Human Hair Proteomics

“…Some recent advances involving the use of structural proteomics as tools to identify disease biomarkers in hair are emerging. For instance, a noninvasive method of breast cancer detection in patient hair using a non‐synchrotron based X‐ray diffraction method has been described . Interestingly, Fourier transformed infra‐red spectroscopy has also been used to identify breast cancer specific lipid changes .…”

Non Invasive XRF Analysis of Human Hair for Health State Determination of Breast Tissue

“…Breast cancer is the most widespread neoplasm in women worldwide ( 1 , 2 ). So, early detection of this type of neoplasm is vital and helps the medical staff for choosing the best treatment strategy and planning ( 3 , 4 ).…”

“…So, early detection of this type of neoplasm is vital and helps the medical staff for choosing the best treatment strategy and planning ( 3 , 4 ). Nowadays, mammography is the gold standard and best modality for diagnose or screening the breast cancer, which helps the physician for early detection of this type of cancer ( 2 ). Many studies have noted that, in addition to patient discomfort and the imposed radiation hazards, false negative reports of mammography may lead to misdiagnosis of breast cancer ( 5 ).…”