Detection of BRCA1 gene mutations in families with breast cancer patients and their healthy relatives.

Spanish family study on hereditary breast and/or ovarian cancer: Analysis of theBRCA1 gene

“…Mutations in the BRCA1 gene account for approximately 45% of breast cancer families and almost 100% of breast/ovarian cancer families 6 . One study determined that only 3.5% of Spanish breast cancer families harbor deleterious BRCA1 mutations but did not study breast/ovarian families 12 . However, other studies suggest a lower prevalence 8 .…”