Detection of BRAF mutations in patients with hairy cell leukemia and related lymphoproliferative disorders

Constant activation of the RAF-MEK-ERK pathway as a diagnostic and therapeutic target in hairy cell leukemia

“…5,6 Our findings have been subsequently confirmed by others. [7][8][9][10][11] BRAF is a kinase of the RAS-RAF-MEK-ERK pathway which plays a pivotal role in regulating cell proliferation and survival. 12 The V600E phospho-mimetic substitution leads to constitutive activation of BRAF that, in turn, phosphorylates MEK (its immediate downstream target) and ERK (the kinase phosphorylated by phospo-MEK).…”

Lymphoma classification and the tools of our trade: an introduction to the 2012 USCAP Long Course

“…For example, it has been learned only recently that hairy cell leukemia but very few other B-cell neoplasms have BRAF V600E mutations. [38][39][40][41] One must be careful, however. In contrast to some reports of no such mutations in other B-cell lymphoid neoplasms, others do report occasional such cases.…”

Extranodal and splenic small B-cell lymphoma

“…63,64 Genetic studies have identified BRAF V600E mutation to be present in all cases of HCL studies whereas this is rare in other splenic B-cell lymphomas. 65,66 Splenic B-cell lymphoma/leukaemia, unclassifiable…”