Detection of Borna disease virus p24 RNA in peripheral blood cells from Brazilian mood and psychotic disorder patients

Failure to Detect Borna Disease Virus Antibody and RNA from Peripheral Blood Mononuclear Cells of Psychiatric Patients

“…With the knowledge of the sequence and genomic organization of BDV, Bode et al19 first detected BDV RNA by reverse transcriptase polymerase chain reaction (RT-PCR) in various psychiatric patients. Other investigators have revealed the possible relationship between BDV and human psychiatric diseases in various regions such as Europe,20-22 Brazil,23,24 and Japan 13,25,26. However, due to the lack of reliable diagnostic tools for BDV detection, subsequent studies could not replicate BDV-positive results (Table 1), and it remains unclear whether BDV is associated with human psychiatric diseases 27…”

Borna Disease Virus P Protein Affects Neural Transmission through Interactions with Gamma-Aminobutyric Acid Receptor-Associated Protein

“…BDV is an infectious agent that causes CNS diseases in a wide range of vertebrate species and perhaps in humans (1,19,25). The P protein of BDV, which is abundantly expressed in infected cells and animal brains, plays important roles in the regulation of the polymerase complex of BDV by binding to the viral proteins N, X, and L (16,24,27,28).…”

“…BDV was reported to cause diseases of the central nervous system (CNS) in sheep and horses originally and then in a wide range of other vertebrate species (25). Epidemiological studies have shown that a higher prevalence of BDV infection was found in psychiatric patients than in controls, indicating that BDV is a potential human pathogen related to psychiatric diseases (1,19). In contrast, some reports suggested that BDV does not play significant roles in human health (9,36).…”

Implicating the Need for Serological Testing of Borna Disease Virus and Dengue Virus During Blood Transfusion

“…The infection of BDV was analysed by western blot, ELISA, immunofluorescence assay, immunoprecipitation, circulating immune complexes (CIC) from the serum of the patients with psychiatric illness, affective disorder, schizophrenia and multiple sclerosis (Hornig et al, 2003). Apart from BDV antibodies, BDV RNA was found in peripheral blood cells of psychiatric patients (Miranda et al, 2006;Sauder et al, 1996). Bode et al, (2001) reported that BDV-CIC play a major role in detection of BDV activity in contrast to the state of illness.…”

“…BDV infection has been reported in psychiatric illness by the presence of BDV RNA, antigen, circulating immune complex (CIC) in blood and post-mortem brain in psychiatric patients Bode et al, 1995;Miranda et al, 2006;Sauder et al, 1996;Terayama et al, 2003). Amantadine is said to improve psychiatric illness such as mania and depression in bipolar disease and depressive patients (Dietrich et al, 2000;Moryl et al, 1993;Ohlmeier et al, 2007;Ohlmeier et al, 2008).…”