Detection of border disease virus (BDV) genotype 3 in Italian goat herds

Rosamilia, Alfonso; Grattarola, Carla; Caruso, Claudio; Peletto, Simone; Gobbi, E.; Tarello, V.; Caroggio, P.; Dondo, Alessandro; Masoero, Loretta; Acutis, Pier Luigi

doi:10.1016/j.tvjl.2013.12.006

Cited by 23 publications

(15 citation statements)

References 29 publications

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“…No correlation was observed between pestiviruses isolated from sheep and goats in this study and strains previously isolated from small ruminants in Italy and classified into different subtypes of the BDV genotype (Rosamilia et al, 2014;Giammarioli et al, 2015b).…”

Section: Resultscontrasting

confidence: 61%

Evidence for Tunisian-Like Pestiviruses Presence in Small Ruminants in Italy Since 2007

Ciulli

Purpari

Agnello

et al. 2016

Transbound Emerg Dis

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The genus Pestivirus, which belongs to the Flaviviridae family, includes ssRNA+ viruses responsible for infectious diseases in pigs, cattle, sheep, goats and other domestic and wild ruminants. Like most of the RNA viruses, pestivirus has high genome variability with practical consequences on disease epidemiology, diagnosis and control. In addition to the officially recognized species in the genus Pestivirus, such as BVDV-1, BVDV-2, BDV and CSFV, other pestiviruses have been detected. Furthermore, most of the ruminant pestiviruses show low or absent species specificity observed in serological tests and are able to infect multiple species. Particularly, small ruminants are receptive hosts of the most heterogeneous group of pestiviruses. The aim of this study was to carry out the molecular characterization of pestiviruses isolated from sheep and goats in Sicily, Italy. Phylogenetic analysis of two viral genomic regions (a fragment of 5'-UTR and the whole N regions) revealed the presence of different pestivirus genotypes in the analysed goat and sheep herds. Two of five viral isolates were clustered with BVDV-1d viruses, a strain widespread in Italy, but never reported in Sicily. The other three isolates formed a distinct cluster with high similarity to Tunisian isolates, recently proposed as a new pestivirus species. This represents the first evidence for Tunisian-like pestivirus presence in small ruminants in Italy. Furthermore, one of the isolates was collected from a goat, representing the first isolation of Tunisian-like pestivirus from this species.

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Section: Resultscontrasting

confidence: 61%

Evidence for Tunisian-Like Pestiviruses Presence in Small Ruminants in Italy Since 2007

Ciulli

Purpari

Agnello

et al. 2016

Transbound Emerg Dis

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“…Previous epidemiologic data have described the circulation of two subtypes, BDV-7 and BDV-3 [11,17,18]. Despite the small number of isolates analysed in our work, the phylogenetic analysis of the viral sequences made possible the classification of the Italian isolates in four distinct genetic groups: BDV-1, BDV-3, BDV-5, and BDV-7.…”

mentioning

confidence: 82%

“…These viruses, according to their clustered antigenic and genetic properties, together with the 712/02 strain, make up a novel phylogenetic group named BDV-7 [11]. Recently, cases of abortion, stillbirth, and weak live kids have been reported in goat herds in northern Italy, and the aetiological agent was identified as BDV-3 [18]. The aim of this work was to further investigate the genetic heterogeneity of BDV isolates from Italy by performing a genetic analysis of the 5 0 -untranslated region (5 0 -UTR) of the genome.…”

mentioning

confidence: 99%

Genetic characterization of border disease virus (BDV) isolates from small ruminants in Italy

et al. 2015

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Border disease virus (BDV) belongs to the Pestivirus genus in the family Flaviviridae. Genetic analyses of pestiviruses that have been isolated from sheep and goat have led to the proposal that BDV isolates can be phylogenetically segregated into at least seven clusters, subtypes BDV-1 to BDV-7. In order to investigate the genetic heterogeneity of small ruminant pestivirus isolates in Italy, a selection of 5'-UTR sequences from isolates that were collected from clinical specimens between 2002 and 2014 was analysed. Phylogenetic reconstructions indicated that the BDV-positive samples clustered within the BDV-1, BDV-3, BDV-5, and BDV-7 groups. These results suggested high genetic diversity within the Italian BDV field isolates. The phylogenetic analysis indicated the first evidence of BDV-1 and BDV-5 circulation in Italy. The marked diversity of the pestivirus isolates might reflect the sheep trade with foreign countries.

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“…The figure was taken from Liu, Xia, Wahlberg, Belak, and Baule (2009). review. For more information on genotypes, we refer to corresponding publications ( Jenckel et al, 2014;Luzzago et al, 2014;Pan et al, 2005;Paton et al, 2000;Postel et al, 2012;Rosamilia et al, 2014).…”

Section: Taxonomy Hosts and Diseases 21 Taxonomy: Approved And Tenmentioning

confidence: 99%

The Molecular Biology of Pestiviruses

Tautz

Tews

Meyers

2015

Advances in Virus Research

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Detection of border disease virus (BDV) genotype 3 in Italian goat herds

Cited by 23 publications

References 29 publications

Evidence for Tunisian-Like Pestiviruses Presence in Small Ruminants in Italy Since 2007

Evidence for Tunisian-Like Pestiviruses Presence in Small Ruminants in Italy Since 2007

Genetic characterization of border disease virus (BDV) isolates from small ruminants in Italy

The Molecular Biology of Pestiviruses

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