Detection of bone marrow‐derived fibrocytes in human dental pulp repair

Yoshiba, Nagako; Edanami, Naoki; Tohma, Aiko; Takeuchi, Ryosuke; Ohkura, Naoto; Hosoya, Akihiro; Noiri, Yuichiro; Nakamura, Hiroaki; Yoshiba, Kunihiko

doi:10.1111/iej.12940

Cited by 10 publications

(11 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…, Yoshiba et al . ). Notably, for didactic purposes, the processes of reactionary and reparative dentinogenesis are considered separately, and it is likely that in a deep carious lesion both processes will occur simultaneously particularly at the periphery of the cavity (Smith et al .…”

Section: Reviewmentioning

confidence: 97%

“…In addition, bone marrow fibrocytes migrate to the injured pulp site to participate in early wound healing (Yoshiba et al . ). Progenitor cells migrate and differentiate to form odontoblast‐like cells during reparative dentinogenesis.…”

Section: Reviewmentioning

confidence: 97%

“…Mild irritation induces an up-regulation of existing odontoblast activity to form reactionary dentine, whilst stronger stimuli result in odontoblast death and the initiation of complex processes involving the recruitment of dental pulp stem/progenitor cells, which differentiate into odontoblast-like cells to form reparative dentine (Lesot et al 1994). Alternative theories disagree with the accepted theory of odontoblast-like cytodifferentiation, highlighting that other cells such as fibroblasts or fibrocytes may in fact produce the mineralized tissue (Ricucci et al 2014a, Yoshiba et al 2018. Notably, for didactic purposes, the processes of reactionary and reparative dentinogenesis are considered separately, and it is likely that in a deep carious lesion both processes will occur simultaneously particularly at the periphery of the cavity .…”

Section: Histopathology Of Caries Within Dentinementioning

confidence: 99%

“…Although the bulk of attention has focused on the role of odontoblast (Simon et al 2009) or SC populations in repair (Frozoni et al 2012), fibroblasts, the principal cell of the pulp, are also able to secrete complement fragments and GFs important to mineralization and SC recruitment (Jeanneau et al 2017). In addition, bone marrow fibrocytes migrate to the injured pulp site to participate in early wound healing (Yoshiba et al 2018). Progenitor cells migrate and differentiate to form odontoblast-like cells during reparative dentinogenesis.…”

Section: Role Of Pulp Cells In Repairmentioning

confidence: 99%

See 3 more Smart Citations

Management of deep caries and the exposed pulp

et al. 2019

View full text Add to dashboard Cite

Caries prevalence remains high throughout the world, with the burden of disease increasingly affecting older and socially disadvantaged groups in Western cultures. If left untreated, caries will advance through dentine stimulating pulpitis and eventually pulp infection and necrosis; however, if conservatively managed, pulpal recovery occurs even in deep carious lesions. Traditionally, deep caries management was destructive with nonselective (complete) removal of all carious dentine; however, the promotion of minimally invasive biologically based treatment strategies has been advocated for selective (partial) caries removal and a reduced risk of pulp exposure. Selective caries removal strategies can be one‐visit as indirect pulp treatment or two‐visit using a stepwise approach. Management strategies for the treatment of the cariously exposed pulp are also shifting with avoidance of pulpectomy and the re‐emergence of vital pulp treatment (VPT) techniques such as partial and complete pulpotomy. These changes stem from an improved understanding of the pulp–dentine complex's defensive and reparative response to irritation, with harnessing the release of bioactive dentine matrix components and careful handling of the damaged tissue considered critical. Notably, the development of new pulp capping materials such as mineral trioxide aggregate, which although not an ideal material, has resulted in more predictable treatments from both a histological and a clinical perspective. Unfortunately, the changes in management are only supported by relatively weak evidence with case series, cohort studies and preliminary studies containing low patient numbers forming the bulk of the evidence. As a result, critical questions related to the superiority of one caries removal technique over another, the best pulp capping biomaterial or whether pulp exposure is a negative prognostic factor remain unanswered. There is an urgent need to promote minimally invasive treatment strategies in Operative Dentistry and Endodontology; however, the development of accurate diagnostic tools, evidence‐based management strategies and education in management of the exposed pulp are critical in the future.

show abstract

Section: Reviewmentioning

confidence: 97%

Section: Reviewmentioning

confidence: 97%

Section: Histopathology Of Caries Within Dentinementioning

confidence: 99%

Section: Role Of Pulp Cells In Repairmentioning

confidence: 99%

See 2 more Smart Citations

Management of deep caries and the exposed pulp

et al. 2019

View full text Add to dashboard Cite

show abstract

“…, Yoshiba et al . ). Perhaps, the lack of a precise odontoblast‐like cell characterization is masking the fact that this phenotype may be more ‘fluid’ than generally acknowledged.…”

Section: Introductionmentioning

confidence: 97%

Dissecting dentine–pulp injury and wound healing responses: consequences for regenerative endodontics

2019

View full text Add to dashboard Cite

Summary A thorough understanding of the biology of the dentine–pulp complex is essential to underpin new treatment approaches and maximize clinical impact for regenerative endodontics and minimally invasive vital pulp treatment (VPT) strategies. Following traumatic and carious injury to dentine–pulp, a complex interplay between infection, inflammation and the host defence responses will occur, which is critical to tissue outcomes. Diagnostic procedures aim to inform treatment planning; however, these remain clinically subjective and have considerable limitations. As a consequence, significant effort has focussed on identification of diagnostic biomarkers, although these are also problematic due to difficulties in identifying appropriate diagnostic fluid sources and selecting reproducible biomarkers. This is further compounded by the link between inflammation and repair as many of the molecules involved exhibit significant multifunctionality. The tertiary dentine formed in response to dental injury has been purposefully termed reactionary and reparative dentine to enable focus on associated biological processes. Whilst reactionary dentine produced in response to milder injury is generated from surviving primary odontoblasts, reparative dentine, in response to more intense injury, requires the differentiation of new odontoblast‐like cells derived from progenitor/stem cells recruited to the injury site. These two diverse processes result in very different outcomes in terms of the tertiary dentine produced and reflect the intensity rather than specific nature (nonexposure versus exposure) of the injury. The subsequent identification of the odontoblast‐like cell phenotype remains challenging due to lack of unique molecular or morphological markers. Furthermore, the cells ultimately lining the newly deposited dentine provide only a snapshot of events. The specific source and plasticity of the progenitor cells giving rise to the odontoblast‐like cell phenotype are also of significant debate. It is likely that improved characterization of tertiary dentine may better clarify the influence of cell derivation for odontoblast‐like cells and their diversity. The field of regenerative endodontics offers exciting new treatment opportunities, and to maximize outcomes, we propose that the term regenerative endodontics should embrace the repair, replacement and regeneration of dentine–pulp.

show abstract