Detection of BCR-ABL kinase domain mutations in CD34+ cells from newly diagnosed chronic phase CML patients and their association with imatinib resistance
Abstract:BCR-ABL kinase domain (KD) mutations, the most common cause of imatinib resistance, are infrequently detected in newly diagnosed chronic-phase chronic myeloid leukemia (CP-CML) patients. Recent studies indicate pre-existing mutations (PEMs) can be detected in a higher percentage of CML patients using CD34 + stem/progenitor cells, and these mutations may correlate with imatinib resistance. We investigated KD mutations in CD34 + stem cells from 100 CP-CML patients by multiplex ASO-PCR and sequencing ASO-PCR prod… Show more
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