Detection of atrial electromechanical dysfunction in obesity

Erdem, Fatma; Öztürk, Serkan; Baltaci, Davut; Dönmez, İbrahim; Alçelik, Aytekin; Ayhan, Suzi Selim; Yazıcı, Mehmet

doi:10.1080/ac.70.6.3120180

Cited by 12 publications

(9 citation statements)

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“…These complex mechanisms in the atrium wall cause an extension in the electromechanical conduction time. In the study of Erdem et al, the EMD time was higher in the adult obese patients compared to the control group [35]. Similar findings were found in the study of Yagmur et al [36].…”

Section: Discussionsupporting

confidence: 75%

Evaluation of Atrial Electromechanical Delay in Children with Obesity

Temiz

Güneş

2019

Medicina

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Background and Objective: Childhood obesity is one of the worldwide health problems with an increasing prevalence and accompanied by severe morbidity and mortality. It is a serious predisposing risk factor especially for the development of cardiovascular diseases and arrhythmias. Electromechanical delay (EMD) is known to be a predictor for the development of atrial fibrillation (AF). Our study aims to investigate whether EMD, which is a predictor of AF, prolongs in obese children or not. Material and Methods: The study included 59 obese patients aged between 8–18 years and 38 healthy patients as the control group with a similar age and gender. All the individuals underwent transthoracic echo and tissue Doppler echocardiography. Systolic and diastolic left ventricular (LV) functions, inter- and intra-atrial electromechanical delay were measured by tissue Doppler imaging (TDI) and conventional echocardiography. Results: Obese patients had significantly lengthened P-wave on surface ECG to the beginning of the late diastolic wave (PA) lateral, PA septum, intra- and inter-atrial electromechanical delays when compared with the control group (p < 0.001, p = 0.001, p < 0.001 and p < 0.001, respectively) Inter-atrial EMD and intra-atrial EMD correlated positively with body mass index (BMI) values (r = 0.484, p < 0.001 and r = 0.376, p = 0.001; respectively) BMI was significantly related with inter-atrial EMD (β = 0.473, p < 0.001) However, there was no relationship between inter-atrial EMD and serum glucose and platelet count. Conclusion: In our study, we declared that electromechanical delay was increased in obese children when compared to the control group and intra- and inter-atrial electromechanical delay was in correlation with body mass index. Furthermore, we discovered that BMI is an independent predictor of the inter-atrial EMD in obese children.

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Section: Discussionsupporting

confidence: 75%

Evaluation of Atrial Electromechanical Delay in Children with Obesity

Temiz

Güneş

2019

Medicina

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“…Previous research has demonstrated that obesity is correlated with LIAEMD, with oxidative stress, neurohormonal activation, and inflammation having been proposed as the mechanisms involved. 26,27 Sleep apnea, which is associated with obesity, may result in changes in the atrial structures, raising the likelihood of the occurrence of LIAEMD. 28 The results of our study also revealed that in patients without diabetes, an increase in the LA volume was allied to a rise in the likelihood of LIAEMD occurrence.…”

Section: Discussionmentioning

confidence: 99%

“…Our findings indicated that patients without diabetes and with obesity had a higher likelihood of LIAEMD occurrence. Previous research has demonstrated that obesity is correlated with LIAEMD, with oxidative stress, neurohormonal activation, and inflammation having been proposed as the mechanisms involved . Sleep apnea, which is associated with obesity, may result in changes in the atrial structures, raising the likelihood of the occurrence of LIAEMD …”

Section: Discussionmentioning

confidence: 99%

Determinants of left intra‐atrial electromechanical delay as evaluated by tissue Doppler imaging in candidates for coronary artery bypass graft surgery

Etemad

Hosseinsabet

2020

Echocardiography

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Objectives Inhomogeneity in the atrial conduction time is a predisposing factor for atrial fibrillation. The aim of our study was to determine the independent determinants of the left intra‐atrial electromechanical delay (LIAEMD) as a marker of left atrial (LA) dyssynchrony in candidates for coronary artery bypass graft surgery (CABGS). Methods This prospective cross‐sectional study recruited 516 consecutive candidates for CABGS. Via the pulsed‐wave tissue Doppler imaging modality in echocardiography, the times between the P wave and the peak of the a′ wave at the septal and lateral mitral annuli were measured and the difference between these times was considered to be LIAEMD. Additionally, clinical and laboratory data on each patient were gathered. The odds ratio for an increased LIAEMD was calculated in patients with and without diabetes in univariate and multivariate analyses. Results The multivariable analysis revealed that in the patients without diabetes, obesity, calcium‐channel blocker usage, an increased maximal LA volume, and a decreased lateral e′/a′ ratio and in the diabetic patients, diuretic usage and a decreased lateral e′/a′ ratio were independently correlated with an increased likelihood of LIAEMD occurrence (P < .05). Conclusions In our study on CABGS candidates, in the patients without diabetes, obesity, an increased maximal LA volume, calcium‐channel blocker usage, and a decreased lateral e′/a′ ratio and in the diabetic patients, diuretic usage and a decreased lateral e′/a′ ratio independently determined increased LIAEMD. The prevention or treatment of factors that are detrimental to the LA electromechanical function may be helpful for the preservation of the LA electromechanical integrity.

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“…Obesity causes an independent increase in risk for development of AF [49]. In addition, obesity is a disease that can cause inter-and intraatrial EMD [13].…”

Section: Dıscussıonmentioning

confidence: 99%

“…However, it has been shown to predict silent AF attacks in patients with high risk of AF [10][11][12]. In addition, EMD has been successfully used to detect arrhythmia-prone atria in the early stages of some diseases that increase the risk of AF [13][14][15]. Detecting early cardiac electrical and structural effects in non-obese NAFLD patients may be important in reducing mortality and morbidity.…”

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confidence: 99%

Early cardiac electrical and structural changes in patients with non-obese non-alcoholic fatty liver disease

et al. 2021

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Background Obese non-alcoholic fatty liver disease (NAFLD) was found to increase the risk of developing atrial fibrillation (AF) regardless of the metabolic syndrome subgroups that may accompany it. In this study, the effect of NAFLD on the structural and electrical functions of the heart was investigated using tissue Doppler echocardiography (TDE) in non-obese NAFLD patients without any known risk factors for AF.Material and methods The study included 43 female patients (31.3±3.8 years), who had stage 2–3 hepatosteatosis detected by liver ultrasonography and diagnosed as non-obese NAFLD (patient group), and 31 healthy women (control group, 32.5±3.6 years). In addition to standard echocardiographic parameters, inter- and intra-atrial electromechanical delay (EMD) were evaluated by TDE.Results Interatrial EMD (PA lateral – PA tricuspid) and intraatrial EMD (PA septum – PA tricuspid) were significantly longer in patient group (16.1±3.4 vs. 12.5±2.3 ms, p<0.001, and 8.4±1.6 vs. 6.6±1.6 ms, p<0.001, respectively). At the subclinical level. atrial size, left ventricular diastolic function, and left ventricular wall thickness measurements were greater in the patient group.Conclusion Inter-atrial and intra-atrial EMD were detected in young women with non-obese NAFLD. In addition, at the subclinical level, structural and functional impairment was detected However, large-volume prospective studies are required to cobfirm these findings regarding the development of AF in non-obese NAFLD patients.

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Detection of atrial electromechanical dysfunction in obesity

Cited by 12 publications

References 0 publications

Evaluation of Atrial Electromechanical Delay in Children with Obesity

Evaluation of Atrial Electromechanical Delay in Children with Obesity

Determinants of left intra‐atrial electromechanical delay as evaluated by tissue Doppler imaging in candidates for coronary artery bypass graft surgery

Early cardiac electrical and structural changes in patients with non-obese non-alcoholic fatty liver disease

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