Detection of Anti-Yellow Fever Virus Immunoglobulin M Antibodies at 3–4 Years Following Yellow Fever Vaccination

Gibney, Katherine B; Edupuganti, Srilatha; Panella, Amanda J.; Kosoy, Olga; Delorey, Mark J.; Lanciotti, Robert S.; Mulligan, Mark J.; Fischer, Marc; Staples, J. Erin

doi:10.4269/ajtmh.2012.12-0182

Cited by 37 publications

(27 citation statements)

References 23 publications

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“…Anti-YFV IgG levels rise a few days after those of IgM, and this is detected in almost all patients by day 14 after symptom onset. However, the timing of antibody detection in natural YFV infections has not been well documented using current IIF or ELISA techniques, and the best data have been generated from the study of responses to the live-attenuated YFV vaccine (51)(52)(53). Additionally, the clinical sensitivity of IgM detection for the diagnosis of natural YFV infection remains unclear, but there is evidence from vaccination trials that anti-YFV IgM levels may be lower among patients with previous flavivirus infections (50,54).…”

Section: Anti-yfv Antibody Detectionmentioning

confidence: 99%

Yellow Fever Virus: Diagnostics for a Persistent Arboviral Threat

2018

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Yellow fever (YF) is the prototypical hemorrhagic fever and results from infection with yellow fever virus (YFV), which is endemic to regions of Africa and South America. Despite the availability of an effective vaccine, YFV continues to cause disease throughout regions where it is endemic, including intermittent large outbreaks among undervaccinated populations. A number of diagnostic methods and assays have been described for the detection of YFV infection, including viral culture, molecular testing, serology, and antigen detection. Commercial diagnostics are not widely available, and testing is generally performed at a small number of reference laboratories. The goal of this article, therefore, is to review available clinical diagnostics for YFV, which may not be familiar to many practitioners outside areas where it is endemic. Additionally, we identify gaps in our current knowledge about YF that pertain to diagnosis and describe interventions that may improve YFV detection.

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Section: Anti-yfv Antibody Detectionmentioning

confidence: 99%

Yellow Fever Virus: Diagnostics for a Persistent Arboviral Threat

2018

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“…Persistence of IgM after a flavivirus infection has been observed. Anti-WNV IgM could still be detected even after 8 year (7), and immune response to YFV vaccine arouse long term IgM presence (6). Recently, anti-ZIKV IgM and neutralizing antibodies were detected in sera up to 19 months after infection (13).…”

Section: Discussionmentioning

confidence: 99%

“…Flaviviruses (6,7), no study has investigated the levels of anti-ZIKV IgM for more than two years, nor there is a study conducted on long term IgM detection in children with microcephaly.…”

Section: Although Cases Of Persistence Of Igm In Serum Have Been Demomentioning

confidence: 99%

Persistence of Anti-Zika Virus Immunoglobulin M Antibodies in Children with Microcephaly up to Four Years after Primary Infection

Campos

Carvalho

Teixeira

et al. 2019

Preprint

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Zika virus (ZIKV) is a member of the flaviviridae family of virus, considered to cause acute selflimited infection in adults, though it may lead to severe complications. It is believed that ZIKV infection elicit a classical viral immune reaction, with primary IgM antibody response and secondary IgG immunity. Persistence of IgM antibodies has been identified for other viruses belonging to the same family as ZIKV. We investigated, therefore, the presence of anti-ZIKV IgM antibodies in children with microcephaly born between January 2015 and November 2018, and their parents. We have detected persistence of IgM in 22% of children with microcephaly up to four years after primary infection. Long term IgM persistence have implications for the diagnosis of acute infection. More investigation is needed in order to correctly construe the significance of anti-ZIKV IgM persistence in the population in general, and in children with microcephaly in particular. The dynamics of IgM antibody responses against ZIKV must be known and understood to avoid misinterpretation of diagnosis for acute infection, re-infection and antibody persistence.

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“…74 Despite subsequent waning, measurable IgM antibodies are still present 3-4 years after vaccination in some individuals. 74,75 In comparison, YF-17D-specific IgG antibodies first appear between days 10 and 17 post-vaccination. Importantly, mice can survive experimental YFV infection after passive immunization with humanized IgG.…”

Section: Humoral Immune Responsesmentioning

confidence: 99%

Guiding dengue vaccine development using knowledge gained from the success of the yellow fever vaccine

2015

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Flaviviruses comprise approximately 70 closely related RNA viruses. These include several mosquito-borne pathogens, such as yellow fever virus (YFV), dengue virus (DENV), and Japanese encephalitis virus (JEV), which can cause significant human diseases and thus are of great medical importance. Vaccines against both YFV and JEV have been used successfully in humans for decades; however, the development of a DENV vaccine has encountered considerable obstacles. Here, we review the protective immune responses elicited by the vaccine against YFV to provide some insights into the development of a protective DENV vaccine.

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Detection of Anti-Yellow Fever Virus Immunoglobulin M Antibodies at 3–4 Years Following Yellow Fever Vaccination

Cited by 37 publications

References 23 publications

Yellow Fever Virus: Diagnostics for a Persistent Arboviral Threat

Yellow Fever Virus: Diagnostics for a Persistent Arboviral Threat

Persistence of Anti-Zika Virus Immunoglobulin M Antibodies in Children with Microcephaly up to Four Years after Primary Infection

Guiding dengue vaccine development using knowledge gained from the success of the yellow fever vaccine

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