Detection of alkyl methylphosphonic acids in complex matrices by gas chromatography–tandem mass spectrometry

Rohrbaugh, D. K.; Sarver, Emory W.

doi:10.1016/s0021-9673(98)00184-8

Cited by 39 publications

(21 citation statements)

References 21 publications

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“…For gas chromatography-tandem mass spectrometry, sensitivities have been demonstrated down to the hundreds-of-picograms level for alkylphosphonic acids leached from of 1 gram of soil. 4 As another example, capillary electrophoresis appears to be sensitive down to the tens-of-nanogram level per gram of soil for the same kind of molecules. 7 The DMMP C -H stretch mode at 2856 cm -1 has a signal-tonoise ratio of 20/1 for the 1 mg DMMP/gram of soil spectrum shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Detection of soil surface contaminants by infrared reflection spectroscopy

Blake

Gassman

2002

SPIE Proceedings

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A benchtop Fourier transform infrared spectrometer and specular reflection accessory have been used to record reflection spectra of several chemical compounds coating a loamy, psamment soil. Unpolarized reflection spectra were recorded between 4600 and 500 cm -1 with a resolution of 4 cm -1 for the compounds dimethyl methylphosphonate, trimethyl phosphate, methylphosphonic acid, 2,2′-thiodiethanol, diazinon, diesel fuel, and ammonium nitrate mixed separately into soil samples with concentrations of 10, 5, and 1 mg of analyte per gram of soil. The soil reflection spectra are compared to liquid or solid transmission spectra of the pure compound and frequency shifts and relative intensity changes for the absorption features are noted. As an example of detection sensitivity, we have estimated that we can detect 300 nanograms of dimethyl methylphosphonate on the surface layer of soil in the focal spot (15 mm 2 ) of the reflection accessory using one of DMMP's C -H stretch modes. The signal-to-noise (peak-to-peak) of this spectral feature under these circumstances would be 3/1. We also estimate that the flux of infrared photons reaching the soil is 10 14 photons/sec/cm -1 . We have recorded polarization-resolved reflection spectra of the uncoated soil and coarse and fine grained quartz sands as a function of angle of incidence and reflection and have determined the degree of polarization for light reflected off of these materials at frequencies associated with volume scattering and surface scattering features. As might be expected, the volume scattering features show a significant depolarization of the light -degree of polarization after reflection is < 20% -and the surface scattering features retain a much higher degree of polarization upon reflection, > 75%. We have also recorded polarization resolved spectra of tributyl phosphate on the soil and found significant differences between the s-and p-polarized spectra. This fact could be used to employ polarization modulation detection to improve detection sensitivity.

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Section: Resultsmentioning

confidence: 99%

Detection of soil surface contaminants by infrared reflection spectroscopy

Blake

Gassman

2002

SPIE Proceedings

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“…Stuff et al published a validated GC/MS method for trace monitoring and quantification of sulphur mustard and sarin neutralisation products [17]. Rohrbaugh and Sarver also presented a screening of trimethylsilyl esters of alkylmethylphosphonic acids in a complex matrix based on GC/MS/MS [18]. Converting the acids into trimethylsilyl derivatives and selected reaction monitoring (MS/MS) led to a complete elimination of background observed in diesel fuel and in soil extracts contaminated with polynuclear aromatic hydrocarbons and pesticides.…”

Section: Gas Chromatographymentioning

confidence: 99%

Utilisation of separation methods in the analysis of chemical warfare agents

et al. 2006

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Chemical warfare agents and their degradation products represent a broad group of compounds with different chemical properties (polarity, volatility, thermostability, etc.). These chemicals often have to be detected and determined in complex matrices and therefore highly efficient separation techniques hyphenated to selective and sensitive detectors play an indispensable role. This review offers an overview of selected papers devoted to the title subject. It cannot be considered as a comprehensive literature compilation but should allow the reader to obtain an insight into the application of separation techniques in the important area of human protection and control of chemical weapons.

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“…[12][13][14][15][16] Unambiguous identification of these compounds requires the availability of spectral data of CWC-related compounds together with the appropriate analytical skills. Since gas chromatography coupled with mass spectrometry (GC/MS) is the most widely used technique for identification of CWC-related compounds (CRCs), [17][18][19][20] a great deal of work has been devoted to the development of a GC/MS database of these compounds. 8,9,[21][22][23][24] The chemicals of significance are listed in three schedules of an annex of the CWC.…”

Section: -12mentioning

confidence: 99%

Gas chromatography/mass spectrometric analysis of N,N‐dialkylaminoethyl‐2‐chlorides and trimethylsilyl derivatives of N,N‐dialkylaminoethan‐2‐ols for verification of the Chemical Weapons Convention

Gupta

Pardasani

Kanaujia

et al. 2006

Rapid Comm Mass Spectrometry

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Gas chromatography/electron ionization mass spectrometry (GC/EI-MS) of N,N-dialkylaminoethyl-2-chlorides (DAAECls) and trimethylsilyl (TMS) derivatives of N,N-dialkylaminoethan-2-ols (DAAEAs) has been carried out. GC/EI-MS data of these compounds are of importance for verification of the Chemical Weapons Convention (CWC). Based on these EI mass spectra, generalized fragmentation routes are proposed that rationalize most of the characteristic ions.

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Detection of alkyl methylphosphonic acids in complex matrices by gas chromatography–tandem mass spectrometry

Cited by 39 publications

References 21 publications

Detection of soil surface contaminants by infrared reflection spectroscopy

Detection of soil surface contaminants by infrared reflection spectroscopy

Utilisation of separation methods in the analysis of chemical warfare agents

Gas chromatography/mass spectrometric analysis of N,N‐dialkylaminoethyl‐2‐chlorides and trimethylsilyl derivatives of N,N‐dialkylaminoethan‐2‐ols for verification of the Chemical Weapons Convention

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