Detection of Age-Related Changes in Thoracic Structure and Function by Computed Tomography, Magnetic Resonance Imaging, and Positron Emission Tomography

Well, David; Meier, Jeffrey; Mahne, Anton; Houseni, Mohamed; Hernandez-Pampaloni, Miguel; Mong, Andrew; Mishra, Saurabh; Zhuge, Ying; Souza, Alex Júnior Souza de; Udupa, Jayaram K.; Alavi, Abass; Torigian, Drew A.

doi:10.1053/j.semnuclmed.2006.10.004

Cited by 22 publications

(20 citation statements)

References 116 publications

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“…Unfortunately, we did not perform pulmonary function tests. However, in the past study, there was no correlation between pulmonary function and CT features [14], so we could define asymptomatic participants based on clinical data from our structured questionnaire.…”

Section: Discussionmentioning

confidence: 99%

“…Plain radiographs reveal hyperinflation of the lungs and bullous spaces in the lungs of both normal and emphysematous patients [13]. Several computed tomography (CT) studies examining lung morphology in elderly revealed air trapping [6,14,15], a subpleural basal reticular pattern, lung cysts [16] and increases in the bronchoarterial ratio, which reflects bronchiectasis [16,17].…”

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confidence: 99%

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CT features of normal lung change in asymptomatic elderly patients

Leelakanok

Piyavisetpat

2015

Asian Biomedicine

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Background: Not all morphological lung changes in the elderly contribute to respiratory disease and may be a consequence of normal aging. Objectives: To describe the changes in asymptomatic elderly patients compared with those in younger patients in a Thai population. Methods: The study cohort comprised 60 participants without respiratory symptoms in three groups of 20 by age: 20−40 years, 41−60 years, and >60 years. Participants were prospectively selected from patients referred for computed tomography (CT) of the abdomen, or head and neck, and underwent sequential CT during deep breathing at four lung levels. Two observers scored images by consensus. We compared groups using Pearson chi-square and Fisher exact tests, and used receiver operating characteristic curves to categorize bronchiectasis and bronchial wall thickening by age. Results: Air trapping was related to age (5/20 group 1, 7/20 group 2, and 18/20 group 3 (P <0.01)) and was most prevalent in lower lobes (78%, P < 0.01). Reticulation was found in only one middle aged patient (P = 0.36). Bronchiectasis was more common in patients <56 years (7/23) than <56 years (3/37), P = 0.035. Bronchial wall thickening (7/23 in patients >56 years and 2/37 in patients <56 years, P = 0.02) and extensive air trapping were related to age (0/6 group 1, 1/6 group 2, and 5/6 group 3, P = 0.02). Findings were independent of smoking history. Conclusions: Asymptomatic older patients had higher prevalence of bronchiectasis, bronchial wall thickening, and air trapping, independent of smoking history.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

CT features of normal lung change in asymptomatic elderly patients

Leelakanok

Piyavisetpat

2015

Asian Biomedicine

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“…The two components of the elastic properties of the lung are surface and tissue forces. (31) There is no evidence that the surface-active lining of terminal respiratory units changes its basic mechanical behavior with age. No changes in the quality or quantity of alveolar surfactant have been described, and there is no evidence of changes in type II pneumocyte function.…”

Section: Aging-related Changes In Radiological Findings In the Lung Pmentioning

confidence: 99%

“…(31,32) Lung parenchymal compliance normally decreases with age. (33,34) These changes are generally attributed to changes in lung connective tissue.…”

Section: Aging-related Changes In Radiological Findings In the Lung Pmentioning

confidence: 99%

“…The most widely accepted hypothesis is that lung elastic recoil is lost because of changes in the spatial arrangement of the network of collagen fibers or because of a protein known as pseudoelastin. (31) Studies of the senescence-accelerated mouse have shown remarkably increased alveolar duct size during the aging process. Enlarged terminal air spaces have also been reported, having been characterized as a relatively homogeneous destruction, with few cellular infiltrates in the alveoli, suggesting that, unlike what occurs in emphysema, air space enlargement was not due to inflammation of the lung parenchyma.…”

Section: Aging-related Changes In Radiological Findings In the Mediasmentioning

confidence: 99%

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O tórax e o envelhecimento: manifestações radiológicas

Hochhegger¹,

Meirelles

Irion

et al. 2012

J. bras. pneumol.

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In the elderly (conventionally defined as individuals ≥ 60 years of age), it is often difficult to establish what normality is, because of the numerous anatomical and physiological modifications that occur during the aging process. As a result, the greatest challenge is to differentiate between the normal aging process and the onset of disease. Healthy elderly people commonly present borderline findings on chest imaging. We systematically reviewed the medical literature on the subject, covering the period between 1950 and 2011, including articles in Portuguese, English, French, Italian, and Spanish. We searched the PubMed, LILACS, and SciELO databases, using the search terms "age", "aging", "lung", "thorax", "chest", "X-ray", "radiography", "pulmonary", and "computed tomography"-as well as their corresponding translations-in various combinations. We included only original or review articles on aging-related chest imaging findings. In broad terms, aging results in physiological modifications that must be recognized so as not to be erroneously interpreted as pathological.Keywords: Aging; Thorax; Lung; Diagnostic imaging. ResumoNos idosos (convencionalmente definidos como indivíduos com idade ≥ de 60 anos), é muitas vezes difícil estabelecer o que é normal devido a inúmeras modificações anatômicas e fisiológicas que ocorrem durante o processo de envelhecimento. Como resultado, o principal problema consiste em diferenciar o ponto em que o envelhecimento é normal daquele no qual a doença começa. Os achados radiológicos do tórax de pessoas idosas sadias são comumente limítrofes. Revisamos sistematicamente a literatura médica sobre o assunto, abrangendo o período entre 1950 e 2011, incluindo artigos em português, inglês, francês, italiano e espanhol. A busca foi feita através das bases de dados PubMed, LILACS e SciELO, utilizando os seguintes termos: age, aging, lung, thorax, chest, X-ray, radiography, pulmonary, computed tomography e suas traduções correspondentes, em combinações variadas. Os critérios de inclusão foram artigos originais e de revisão de achados radiológicos no tórax relacionados ao envelhecimento. Em linhas gerais, o envelhecimento resulta em modificações fisiológicas que devem ser reconhecidas de forma a não serem erroneamente interpretadas como patologias.Descritores: Envelhecimento; Tórax; Pulmão; Diagnóstico por imagem.* Study carried out at the

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