Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer's disease using magnetic resonance diffusion tensor imaging

Sun, Shu-Wei; Song, Sheng‐Kwei; Harms, Michael P.; Lin, Shiow-Jiuan; Holtzman, David M.; Merchant, Kalpana; Kotyk, John J.

doi:10.1016/j.expneurol.2004.09.006

Cited by 114 publications

(108 citation statements)

References 39 publications

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“…We followed the assumption, arising out of experiments on animal models, that a reduction in DR might signify a loss of myelin integrity and that a reduction of DA might implicate axonal damage expected with Wallerian degeneration [71,73,74]. Our results [21] suggest that both these mechanisms affecting the callosal WM are present.…”

Section: Possible Underlying Mechanismsmentioning

confidence: 87%

“…In fact, structural MRI techniques, which reflect macrostructural changes, may not be sensitive to the degeneration of myelin and axons in the WM microstructure [28,46]. On the contrary, DWI and DTI parameters have been applied in CC studies and have demonstrated much greater sensitivity in revealing the WM degeneration in AD than conventional MRI imaging techniques [68,71,77].…”

Section: Diffusion-weighted Imaging and Diffusion Tensor Imaging Studiesmentioning

confidence: 99%

“…down of tissue cytoarchitecture [68,69], sclerosis [70], or demyelinating processes [71][72][73][74]. Recently, Choi and colleagues [75] began investigating other measures of diffusion, such as radial diffusivity (DR) and axial diffusivity (DA), to determine whether differences in anisotropy are caused by diffusion perpendicular or parallel to the WM fibers, respectively.…”

Section: Diffusion-weighted Imaging and Diffusion Tensor Imaging Studiesmentioning

confidence: 99%

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In Vivo Structural Neuroanatomy of Corpus Callosum in Alzheimer's Disease and Mild Cognitive Impairment Using Different MRI Techniques: A Review

Paola

Spalletta

Caltagirone

2010

JAD

128

103

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Abstract. The corpus callosum (CC), which connects the two cerebral hemispheres, is the largest white matter fiber bundle in the human brain. This structure presents a peculiar myelination pattern: it has small diameter fibers, located in the genu, which myelinate much later in normal development, and large diameter fibers of the splenium, which myelinate early in development. Although the pathology of AD mainly involves the cerebral gray matter structure, there is evidence that white matter may also be involved. To illustrate callosal white matter changes in AD pathology, in this review we summarize in vivo imaging studies in humans, focusing on region of interest, voxel-based morphometry, diffusion-weighted imaging, and diffusion tensor imaging techniques. Our aims were to identify where in the CC, when in the different stages of AD, and how callosal changes can be detected with different MRI techniques. Results showed that changes in the anterior (genu and anterior body) as well as in the posterior (isthmus and splenum) portions of the CC might already be present in the early stages of AD. These findings support the hypothesis that two mechanisms, Wallerian degeneration and myelin breakdown, might be responsible for the region-specific changes detected in AD patients. Wallerian degeneration affects the posterior CC subregion, which receives axons directly from those brain areas (temporo-parietal lobe regions) primarily affected by the AD pathology. Instead, the myelin breakdown process affects the later-myelinating CC subregion and explains the earlier involvement of the genu in CC atrophy.

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Section: Possible Underlying Mechanismsmentioning

confidence: 87%

Section: Diffusion-weighted Imaging and Diffusion Tensor Imaging Studiesmentioning

confidence: 99%

Section: Diffusion-weighted Imaging and Diffusion Tensor Imaging Studiesmentioning

confidence: 99%

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In Vivo Structural Neuroanatomy of Corpus Callosum in Alzheimer's Disease and Mild Cognitive Impairment Using Different MRI Techniques: A Review

Paola

Spalletta

Caltagirone

2010

JAD

128

103

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“…27 Our results are also consistent with an earlier DTI study in a transgenic mouse model of ␤-amyloid deposition. 41 Using the APPsw transgenic mouse (Tg2576), Sun et al 41 demonstrated significant decreased DA with largely unaltered DR in the white matter of a group of transgenic mice, compared with a group of age-matched wild-type mice.…”

Section: Discussionmentioning

confidence: 99%

Diffusion Tensor Imaging of Normal-Appearing White Matter in Mild Cognitive Impairment and Early Alzheimer Disease: Preliminary Evidence of Axonal Degeneration in the Temporal Lobe

Huang

Friedland²,

Auchus³

2007

American Journal of Neuroradiology

204

138

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“…That is, water will preferentially diffuse more rapidly along white matter tracts because physical barriers such as axonal walls restrict water movement in other directions (Beaulieu, 2002;Sun et al, 2005). Medical conditions such as subcortical ischemic injury, inflammation, neurodegenerative diseases, and traumatic brain injury cause reductions in the linear organization of white matter pathways with corresponding reductions in linear anisotropy (Beaulieu, 2002;Sun et al, 2005). DTI is sensitive to these changes in linear anisotropy making it a powerful in vivo imaging tool for studying the microstructural integrity of cerebral white matter.…”

Section: Introductionmentioning

confidence: 99%

Quantitative tractography metrics of white matter integrity in diffusion-tensor MRI

et al. 2008

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We present new quantitative diffusion-tensor imaging (DTI) tractography-based metrics for assessing cerebral white matter integrity. These metrics extend prior work in this area. Tractography models of cerebral white matter were produced from each subject's DTI data. The models are a set of curves (e.g., "streamtubes") derived from DTI data that represent the underlying topography of the cerebral white matter. Nine metrics were calculated in whole brain tractography models and in three "tracts-of-interest" (TOI): transcallosal fibers, and the left and right cingulum bundles. The metrics included the number of streamtubes and several metrics based on the summed length of streamtubes in including some that were weighted by scalar anisotropy metrics and normalized for estimated intracranial volume. We then tested whether patients with subcortical ischemic vascular disease (i.e., vascular cognitive impairment or VCI) vs. healthy controls (HC) differed on the metrics. The metrics were significantly lower in the VCI group in whole brain and in transcallosal TOI but not in the left or right cingulum bundles. The metrics correlated significantly with cognitive functions known to be impacted by white matter abnormalities (e.g., processing speed) but not with those more impacted by cortical disease (e.g., naming). These new metrics help bridge the gap between DTI tractography and scalar analytical methods and provide a potential means for examining group differences in white matter integrity in specific tracts-of-interest.

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Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer's disease using magnetic resonance diffusion tensor imaging

Cited by 114 publications

References 39 publications

In Vivo Structural Neuroanatomy of Corpus Callosum in Alzheimer's Disease and Mild Cognitive Impairment Using Different MRI Techniques: A Review

In Vivo Structural Neuroanatomy of Corpus Callosum in Alzheimer's Disease and Mild Cognitive Impairment Using Different MRI Techniques: A Review

Diffusion Tensor Imaging of Normal-Appearing White Matter in Mild Cognitive Impairment and Early Alzheimer Disease: Preliminary Evidence of Axonal Degeneration in the Temporal Lobe

Quantitative tractography metrics of white matter integrity in diffusion-tensor MRI

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