Detection of adverse drug reactions using hospital databases—a nationwide study in Portugal

Abstract

Several methods have been used for the detection of ADRs, but they are difficult to apply at a national level. Spontaneous reporting is widely used but grossly underestimates the frequency of ADRs. The database methodology can be very useful to estimate ADRs frequency and to perform a simple characterization of ADRs nationwide.

Detection of adverse drug reaction (ADR)-related hospital admissions: A pilot study using administrative database for ADR monitoring in Thailand

“…This is consistent with the major drugs groups most frequently associated with ADRs identified from external code as neutropenia was common side effect of antineoplastic drugs and systematic antibiotic while hypoglycemia was common side effect of insulin. In addition, our findings were similar to those of the previous study 14 , which found that neutropenia, hypoglycemia were the common ADRs found from hospital database. According to our results, caution should be made to monitor safety among patients who were prescribed with those drugs.…”

“…When looking at trend of ADRs, similar to the previous studies [14][15][16]19 , we found that incidence of ADR-related hospital admission was increasing, which might be due to the introduction of new drugs, poly-pharmacotherapy, increasing aging population, and improvement of diagnostic and coding practice.…”

“…As the result, administrative database has substantial potential to be continuously used to monitor ADRs for national perspective as supplement to established methods such as spontaneous report. In fact, the use of hospital administrative data is proven to be a reliable and valid method for monitoring patient's safety in several developed countries [12][13][14][15][16][17][18][19] . To our knowledge, no study has been conducted to determine the prevalence of ADR among hospitalized patients in less developed country using administrative database before.…”

Hospitalizations in Children with a Penicillin Allergy Label: An Assessment of Healthcare Impact

“…This corresponds to less than 1% of all hospitalizations of children during this period. Although this rate is consistent with previous reports based on administrative databases [20], it is considerably lower than rates found by studies that have used other methodological approaches. In one chart review study, for example, approximately 16% of inpatients had a penicillin allergy label in their medical records [21].…”

Pharmacogenetic Profile of a South Portuguese Population: Results from the Pilot Study of the European Health Examination Survey in Portugal

“…A recent meta-analysis [5] has indicated that ADRs may occur in 16.88% of hospitalized patients. In Portugal, 16,720 ADRs were identified among 9,271,122 hospitalizations between 2000 and 2009, representing 1.26% of the total hospitalized patients [6]. By improving the predictability of drug response in individual patients through the application of genetic information in guiding drug therapy decisions, it will be possible to avoid ADRs and to improve drug efficacy and safety [7].…”