Detection of Adenovirus Infection Among Children With Acute Respiratory Disease During 2010-2012 in Shiraz, Iran

Abstract

Background: Acute viral respiratory infection (ARVI) is a common cause of morbidity and mortality especially in pediatric patients. Among important respiratory pathogens, adenovirus is a most prevalent cause of upper and lower respiratory tract infection. Objectives: The aim of the present study was to determine the prevalence of adenovirus infection in pediatric patients with respiratory symptoms. Patients and Methods: This cross-sectional study was carried out from November 2010 to February 2012. An in-house nested-PCR was used to detect adenovirus in nasopharyngeal swabs from 328 children, aged 19 years or younger, with acute upper respiratory tract symptoms referred to the hospitals affiliated with Shiraz University of Medical Sciences. Results: Adenovirus was detected in 22% of 328 nasopharyngeal swabs and the highest rate of hospitalization (74%) due to ARVI associated with fever, cough and muscular ache was found in children older than five years. Conclusions: The results of this study showed that acute respiratory infection due to adenovirus in Shiraz mostly occur during November to February. In contrast to other studies, adenovirus infection was more prevalent in children aged older than 5 years.

Adenoviruses Type D in Patients with Respiratory Tract Infection Symptoms

“…In total of 400 patients, 37 cases (9.2%) were infected with adenovirus that the frequency was similar to study of Echavaria and his Colleagues in Argentina [14] and that is lower than the frequency of 14.4% and 22% reported by another study from Iran [1] [15] [16] and several parts of the world including Oman (15%), Kenya (14%), Korea (10.3%), Canada (7.73%), Brazil (7.1%), Australia (7.3%), Hung Kong (5.3%), Mejia (5.2%), and China (4.9%) [1] [17] [18].…”

“…Different factors are involved including respiratory syncytial virus (RSV), influenza virus, parainfluenza virus (PIV), rhinovirus (RV), and human adenovirus (HAdV) [1].…”

Molecular Diagnosis of Human Adenovirus in Children with Upper Respiratory Tract Infections

“…The statistical analysis revealed a significant difference between groups (X 2 = 11.064; P<0.01), where the viral DNA was detected in approximately a third (28.08%) of the total study groups (Table 3-1). The frequency of HAdVs positive cases in our study was higher for most studies than that reported in the Middle East such as Turkey 26.2% [17], Iran 14.4-22% [18][19][20], Israel 18.3% [21], Saudi Arabia 17.4% [22]. Other parts of the world reported different values like Kenya 14% [23], Korea 10.3% [24], Australia 7.3% [25], and Peru 6.2% [26].…”

“…Only limited studies showed significant differences between male and female in which the infectious rate of HAVs in males were higher than females [26,35]. Also, Moattari et al, a study in Iran showed that the infectious rate of HAV was high in females than in males [20].…”

Prevalence of Human Adenoviruses in Respiratory Tract-infected Patients in Anbar Governorate (West of Iraq): A Descriptive Cross-sectional Study

“…1,2 Adenovirus is the greatest reason for upper and lower respiratory tract disease, 3 and constitutes 5-8% of all Respiratory tract infections (RTIs) in neonate and children. 3,4 Other research showed that Adenovirus infection range between 5 to 15% of upper and lower RTIs in hospitalized children for respiratory disease. 5,6 Adenovirus (AdV) is considered one of the greatest public viruses causing RTIs in immunocompetent adults and elderly persons.…”