Detection of acute stress by smooth muscle electromyography: A translational study on rat and human

Pribék, Ildikó Katalin; Szűcs, Kálmán Ferenc; Süle, Miklós; Grosz, György; Ducza, Eszter; Vigh, Dóra; Tóth, É.; Janka, Zoltán; Kálmán, Jánoš; Datki, Zsolt; Gáspár, Róbert; Andó, Bálint

doi:10.1016/j.lfs.2021.119492

Cited by 6 publications

(9 citation statements)

References 35 publications

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“…There was no significant difference found in the electric signal activity of the small intestine of the control and exercised rats. The evaluation of the signals was done following the method by Pribek et al (2021) . The representative signals of the control (N = 6) and VE (N = 8) animals are shown in Figure 2 .…”

Section: Resultsmentioning

confidence: 99%

“…We measured the myoelectric activity of the stomach, ileum, and cecum using transcutaneous electrical nerve recording surface electrodes to record smooth muscle electromyography (SMEMG) as described earlier ( Pribek et al, 2021 ). The electrodes (Electrode PE Foam Solidgel, Bio Lead-Lok B Sp.…”

Section: Methodsmentioning

confidence: 99%

“…The frequency of the electric activity was characterized in cpm, and the magnitude of the activity was described as power spectrum density (PsD). Regarding the interpretation of the physiological parameters, if the values were >1 standard deviation, they were considered outliers and excluded from the analysis as described earlier ( Pribek et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

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Voluntary exercise does not increase gastrointestinal motility but increases spatial memory, intestinal eNOS, Akt levels, and Bifidobacteria abundance in the microbiome

Bakonyi,

Kolonics,

Aczel

et al. 2023

Front. Physiol.

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The interaction between the gut and brain is a great puzzle since it is mediated by very complex mechanisms. Therefore, the possible interactions of the brain–exercise–intestine–microbiome axis were investigated in a control (C, N = 6) and voluntarily exercised (VE, N = 8) middle-aged rats. The endurance capacity was assessed by VO2max on the treadmill, spatial memory by the Morris maze test, gastrointestinal motility by EMG, the microbiome by 16S RNA gene amplicon sequencing, caveolae by electron microscopy, and biochemical assays were used to measure protein levels and production of reactive oxygen species (ROS). Eight weeks of voluntary running increased VO2max, and spatial memory was assessed by the Morris maze test but did not significantly change the motility of the gastrointestinal tract or production of ROS in the intestine. The protein kinase B (Akt) and endothelial nitric oxide synthase (eNOS) protein levels significantly increased in the intestine, while peroxisome proliferator–activated receptor gamma coactivator 1 alpha (PGC-1α), mitochondrial transcription factor A (TFAM), nuclear respiratory factor 1 (NFR1), SIRT1, SIRT3, nicotinamide phosphoribosyl transferase (NAMPT), and nuclear factor κB (NF-κB) did not change. On the other hand, voluntary exercise increased the number of caveolae in the smooth muscles of the intestine and relative abundance of Bifidobacteria in the microbiome, which correlated with the Akt levels in the intestine. Voluntary exercise has systemic effects and the relationship between intestinal Akt and the microbiome of the gastrointestinal tract could be an important adaptive response.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Voluntary exercise does not increase gastrointestinal motility but increases spatial memory, intestinal eNOS, Akt levels, and Bifidobacteria abundance in the microbiome

Bakonyi,

Kolonics,

Aczel

et al. 2023

Front. Physiol.

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“…1,20 At the psychological level, it is related to post-traumatic stress disorders of mood and sleep disorders. 16,21…”

Section: Psychological Stressmentioning

confidence: 99%

“…18,22 Their overactivation can cause cardiovascular changes, increasing heart rate and blood pressure. 21,27…”

Section: Sam Axis Activitymentioning

confidence: 99%

Clinical relevance of stress biomarkers as health-disease indicators

López

2022

Mex J Med Res

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Stress is a protective mechanism inherent in living organisms. In humans, it fulfils an adaptive function, capable of generating responses at different levels: physiological, metabolic, endocrine, cognitive, among others. Constant exposure to stressful events or stimuli is capable of exceeding the person's resources, causing discomfort and progressively wearing down health. Recently, a significant increase in stress-associated diseases has been observed. The consequences of this problem are multiple; personal, socioeconomic, and professional difficulties. Current evidence shows that daily stress will tend to increase in the upcoming years, affecting the quality of life and mental health of the population in general. Both environmental and natural factors as well as the economic and social repercussions derived from the current pandemic tend to further aggravate this problem. Given this scenario, developing strategies that promote mental health and the prevention of its associated pathologies is a priority. One way to develop more effective intervention programs is through the use of biomarkers, many of which show high diagnostic sensitivity and specificity, and which represent a wide interest within the clinical area and psychotherapeutic intervention. The objective of this article is to make a general review of the main biomarkers used in clinical practice, as well as potential biomarkers that allow the identification of early signs of health problems related to mental stress in a more efficient and accessible way.

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Prediction of gastroesophageal reflux episodes by smooth muscle electromyography: A translational study in rats and adolescents

Nagy¹,

Szűcs²,

Grosz³

et al. 2023

Heliyon

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Detection of acute stress by smooth muscle electromyography: A translational study on rat and human

Cited by 6 publications

References 35 publications

Voluntary exercise does not increase gastrointestinal motility but increases spatial memory, intestinal eNOS, Akt levels, and Bifidobacteria abundance in the microbiome

Voluntary exercise does not increase gastrointestinal motility but increases spatial memory, intestinal eNOS, Akt levels, and Bifidobacteria abundance in the microbiome

Clinical relevance of stress biomarkers as health-disease indicators

Prediction of gastroesophageal reflux episodes by smooth muscle electromyography: A translational study in rats and adolescents

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