Detection of a SARS-CoV-2 variant of concern in South Africa

Tegally, Houriiyah; Wilkinson, Eduan; Giovanetti, Marta; Iranzadeh, Arash; Fonseca, Vagner; Giandhari, Jennifer; Doolabh, Deelan; Pillay, Sureshnee; San, Emmanuel James; Msomi, Nokukhanya; Mlisana, Koleka; Gottberg, Anne von; Walaza, Sibongile; Allam, Mushal; Ismail, Arshad; Mohale, Thabo; Glass, Allison; Engelbrecht, Susan; Zyl, Gert U. van; Preiser, Wolfgang; Petruccione, Francesco; Sigal, Alex; Hardie, Diana; Marais, Gert; Hsiao, Nei‐Yuan; Korsman, Stephen N.J.; Davies, Mary‐Ann; Tyers, Lynn; Mudau, Innocent; York, Denis; Maslo, Caroline; Goedhals, Dominique; Abrahams, Shareef; Laguda-Akingba, Oluwakemi; Alisoltani, Arghavan; Godzik, Adam; Wibmer, Constantinos Kurt; Sewell, B.T.; Lourenço, José; Alcântara, Luíz Carlos Júnior; Pond, Sergei L. Kosakovsky; Weaver, Steven; Martin, Darren P.; Lessells, Richard; Bhiman, Jinal N.; Williamson, Carolyn; Oliveira, Túlio de

doi:10.1038/s41586-021-03402-9

“…The copyright holder for this preprint this version posted March 31, 2021. ; https://doi.org/10.1101/2021.03.29.21254563 doi: medRxiv preprint evident. However, a potential explanation would be the presence of greater RNA quantities of VOC B.1.351 reflected by decreased mean Ct values for all sample types, which may support the preliminary modelling-based finding of increased transmissibility1 . Whilst altered test-seeking behavior in the study population cannot be excluded the inclusion criteria remained the same throughout the study.Whilst further WGS studies are ongoing to determine compartmentalized replication and to inform diagnostic preferences concurrent to public health interventions, knowledge of distinct oral and oropharyngeal shedding dynamics and viral burden through the continuum of SARS-CoV-2 infections is warranted.. CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.…”

supporting

confidence: 58%

“…In December 2020, South Africa (SA) faced a surge in COVID-19 cases, which was associated with the replacement of previous circulating lineages with a novel SARS-CoV-2 variant of concern (VOC) B.1.351 (501Y.V2) lineage 1 . Preliminary analyses .…”

Section: Bodymentioning

confidence: 99%

Improved performance of saliva for the detection of the B.1.351 variant in South Africa

Chu

¹

,

Marais

²

,

Opperman

³

et al. 2021

Preprint

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…Without continual upkeep, amplicon sequencing may yield incomplete SARS-CoV-2 genome sequences and therefore create a loss of valuable genetic information. This could weaken our vigilance towards SARS-CoV-2 mutations, which may impact our diagnostic, therapeutic, and vaccination efforts 4 , and SARS-CoV-2 lineages, especially variants of concern such as B.1.1.7 and B.1.135 that may enhance the virus' transmissibility or lethality 5,6 .…”

Section: Introductionmentioning

confidence: 99%

Target Capture Sequencing of SARS-CoV-2 Genomes Using the ONETest Coronaviruses Plus

Zhan

¹

,

Alamouti

²

,

Kwok

³

et al. 2021

Preprint

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…One particular SARS-CoV-2 variant of concern is the B.1.351, a variant that was originally identified in South Africa and which is now the dominant lineage in circulation within the country 9 . Sequence analysis of B.1.351 identified several amino acid differences between the spike glycoproteins of the B.1.351 lineage viruses and the original Wuhan isolate of SARS-CoV-2.…”

Section: Introductionmentioning

confidence: 99%

Development of highly potent neutralising nanobodies against multiple SARS-CoV-2 variants including the variant of concern B.1.351

Sziemel

¹

,

Hwa

²

,

Sigal

³

et al. 2021

Preprint

Self Cite

Get access via publisher Add to dashboard Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

Detection of a SARS-CoV-2 variant of concern in South Africa

Cited by 1,730 publications

References 59 publications

Improved performance of saliva for the detection of the B.1.351 variant in South Africa

Improved performance of saliva for the detection of the B.1.351 variant in South Africa

Target Capture Sequencing of SARS-CoV-2 Genomes Using the ONETest Coronaviruses Plus

Development of highly potent neutralising nanobodies against multiple SARS-CoV-2 variants including the variant of concern B.1.351

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