Detection of a New Serotype of Escherichia Coli, E. Coli O127: B8, Associated With Acute Diarrhea in Infants

Abstract

In 1927 Adam reported the association of certain fermentative types of Escherichia coli with diarrhea in infants. Goldschmidt (1933) made similar observations. Bray (1945) in England demonstrated the presence of a specific serologic "O" type, 0111, of E. coli in an epidemic of diarrhea among newborn infants and focused attention on E. coli as a possible etiologic agent.

Escherichia coli that Cause Diarrhea: Enterotoxigenic, Enteropathogenic, Enteroinvasive, Enterohemorrhagic, and Enteroadherent

“…neapolitanum; it is now known to belong to serogroup O111. After these results were published, investigators in other countries pursued studies by using the same general approach [9][10][11][12][13][14][15][16][17][18][19][20]. As a consequence, by the mid-1950s, a series of E. coli strains had been epidemiologically incriminated throughout the world as important causes of infant diarrhea [21][22][23]; the term enteropathogenic E. coli (EPEC) was proposed by Neter [24] to refer to these serotypes.…”

The lipopolysaccharide from Escherichia coli O127:B8 induces inflammation and motility disturbances in rabbit ileum

“…Enteropathogenic E. coli 0127:B8 is associated with acute diarrhoea in infants (Cooper et al, 1955), but it has also been reported to be able to attach to rabbit enterocytes (Germani et al, 1985). However, most of the effects of this strain on rabbit intestine remain unexplored.…”