Detection of a new pathogenic Babesia microti-like species in dogs

Zahler, Monika; Rinder, Heinz; Schein, E.; Gothe, R.

doi:10.1016/s0304-4017(00)00202-8

Cited by 226 publications

(187 citation statements)

References 21 publications

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“…According to this classification, the parasites from carnivores, which are clustered with those from rodents, belong to clade 2 (Goethert and Telford, 2003). The parasites that cause fulminating disease in Spanish dogs are included in this clade (Zahler et al, 2000;Camacho et al, 2001;Goethert and Telford, 2003). In our study the parasites isolated from the raccoon dogs belong to clade 2, and they are highly similar to the parasites identified in Spanish dogs (Fig.…”

supporting

confidence: 75%

“…We also examined peripheral blood samples that had been previously collected from 13 additional wild raccoon dogs and stored at 220 C. Identification of parasites was accomplished by amplification of the 18S ribosomal RNA genes using the primers RIB-19 and RIB-20, which amplify a common sequence of the 18S rRNA gene from the genus Babesia (Zahler et al, 2000). Two of the 13 samples yielded PCR products amplified by the RIB-19 and RIB-20 primers.…”

mentioning

confidence: 99%

“…Traditionally, B. canis and B. gibsoni have been considered the two causative species of canine babesiosis (Cacciò et al, 2002). Recently a new B. microti-like species (designated Theileria annae) was shown to induce clinical signs in dogs (Zahler et al, 2000). In South Korea, only B. gibsoni has been associated with infection in dogs (Lee et al, 1998).…”

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confidence: 99%

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Asymptomatic Babesia microti–like parasite infection in wild raccoon dogs (Nyctereutes procyonoides) in South Korea

Han

Lee

Jang

et al. 2010

Journal of Wildlife Diseases

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confidence: 75%

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confidence: 99%

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Asymptomatic Babesia microti–like parasite infection in wild raccoon dogs (Nyctereutes procyonoides) in South Korea

Han

Lee

Jang

et al. 2010

Journal of Wildlife Diseases

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“…On our first report of a series of cases [3], which followed the first case report of the infection by Zahler et al [23], we obtained mean serum values of total protein and albumin which were within commonly accepted normal reference ranges but we did not study the electrophoretic profile associated to the infection. Furthermore, no reference group of noninfected dogs was included for comparison.…”

Section: Introductionmentioning

confidence: 93%

“…Phylogenetic analysis of DNA sequences derived from the polymerase chain reaction (PCR) amplification of ribosomal genes has allowed further subvidision [10] of these taxa. Small Babesia now include two strains of Babesia gibsoni: "Asia" and "California", and a recently identified small Babesia [3,4,23], which is more closely related to Babesia microti than to Babesia gibsoni and has been tentatively referred to as Babesia annae [6]. This newly recognised piroplasm appears to be endemic in NW Spain [3].…”

Section: Introductionmentioning

confidence: 99%

Serum protein response and renal failure in canine Babesia annae infection

Camacho¹,

Guitian

Pallas

et al. 2005

Vet. Res.

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-Babesia annae piroplasms have recently been recognised as a cause of infection and disease among dogs in Europe. The pathogenesis and clinical implications of this emerging disease remain poorly understood. We conducted this study to describe the electrophoretic profiles associated with the infection and to determine if B. annae associated azotaemia is caused by renal failure. We examined by microscopy 2 979 canine blood samples submitted to a diagnostic laboratory in NW Spain between September 2001 and April 2002. Small ring-shaped piroplasms were detected in blood smears of 87 samples and the identity of 58 of these presumptive cases were confirmed by PCR. This group of 58 infected dogs and a reference group of 15 healthy non-infected dogs were our study population. For all the dogs, serum protein response to -albumin, alpha-1 globulin, alpha-2 globulin, beta globulin and gamma globulin-was measured by capillary electrophoresis. The response of infected and non-infected dogs was compared and within infected dogs, the response of those with azotaemia (19) was compared with that of non-azotaemic dogs (39). Infected dogs presented a significant elevation of total proteins and all the different globulin fractions, and significantly lower levels of albumin compared to non-infected dogs. Among infected dogs, those presenting azotaemia had significantly lower concentrations of total proteins, albumin, beta and gamma globulins, and significantly higher values of alpha-2 globulin. Specific gravity was below the threshold of 1 025 for all dogs with azotaemia for which a urine sample was available (7) suggesting that azotaemia, in these dogs was of renal origin. Azotaemic dogs had higher concentrations of cholesterol and triglycerides, probably as a result of a liver compensatory response to the loss of proteins. We conclude that serum protein response in B. annae infected dogs corresponds to the pattern of a haemolytic syndrome with intense inflammatory reaction and that the azotaemia associated to the infection is very likely of renal origin. serum proteins / Babesia annae / azotaemia / renal failure

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Molecular identification of Babesia canis canis genotype A in a dog from Iran

Ghasemzade

Esmaeilnejad

Asri‐Rezaei

et al. 2021

Veterinary Medicine & Sci

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Background: Canine babesiosis is a common and clinically significant tick-borne disease caused by obligate haematozoan parasites of the genus Babesia.Purpose: To report Babesia canis canis genotype A infection in a dog. Methods:A 2-year-old female Shih Tzu dog was submitted with the history of anorexia and depression for one week and no prior surgery. Fever, anorexia, depression and vomiting as well as mucosal pallor were noticed on physical examination. Microscopic examination of the Giemsa-stained blood smear disclosed large form of Babesia, and single to four pear-shaped merozoites within erythrocytes (RBCs). The specific primers were used for detecting Babesia canis. Results:The result of PCR was confirmed by 18S rRNA gene sequence analyzing and has been registered in GenBank under following accession numbers for Babesia canis canis (MW199108). The sequences were compared to those in GenBank, and alignments showed that the B. canis canis isolate belonged to genotype A.Conclusions: This is the first description of B. canis canis genotype A in dog from Iran.

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Detection of a new pathogenic Babesia microti-like species in dogs

Cited by 226 publications

References 21 publications

Asymptomatic Babesia microti–like parasite infection in wild raccoon dogs (Nyctereutes procyonoides) in South Korea

Asymptomatic Babesia microti–like parasite infection in wild raccoon dogs (Nyctereutes procyonoides) in South Korea

Serum protein response and renal failure in canine Babesia annae infection

Molecular identification of Babesia canis canis genotype A in a dog from Iran

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