Detection of a new bat gammaherpesvirus in the Philippines

Watanabe, Shumpei; Ueda, Naoya; Iha, Koichiro; Masangkay, Joseph S.; Fujii, H.; Alviola, Phillip A.; Mizutani, Tetsuya; Maeda, Ken; Yamane, Daisuke; Azab, Walid; Kato, Kentaro; Kyuwa, Shigeru; Tohya, Yukinobu; Yoshikawa, Yasuhiro; Akashi, Hiroomi

doi:10.1007/s11262-009-0368-8

Cited by 32 publications

(25 citation statements)

References 9 publications

(10 reference statements)

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“…dupreanum , Pteropus lylei (a nectarivorous bat), Lonchophylla thomasi , and an unidentified bat [5, 6]. Several betaherpesviruses and gammaherpesviruses have also been detected in bats from the families Vespertilionidae [7,8], Miniopteridae [9, 10], Pteropodidae [11], Hipposideridae [12] and Rhinolophidae [8]. Nevertheless, with the exception of a few vespertilionid gammaherpesviruses described by Wibbelt et al [7], relatively little is known about the phylogenetic relationships among the different bat herpesvirus species.…”

Section: Introductionmentioning

confidence: 99%

Identification of Novel Betaherpesviruses in Iberian Bats Reveals Parallel Evolution

et al. 2016

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A thorough search for bat herpesviruses was carried out in oropharyngeal samples taken from most of the bat species present in the Iberian Peninsula from the Vespertilionidae, Miniopteridae, Molossidae and Rhinolophidae families, in addition to a colony of captive fruit bats from the Pteropodidae family. By using two degenerate consensus PCR methods targeting two conserved genes, distinct and previously unrecognized bat-hosted herpesviruses were identified for the most of the tested species. All together a total of 42 potentially novel bat herpesviruses were partially characterized. Thirty-two of them were tentatively assigned to the Betaherpesvirinae subfamily while the remaining 10 were allocated into the Gammaherpesvirinae subfamily. Significant diversity was observed among the novel sequences when compared with type herpesvirus species of the ICTV-approved genera. The inferred phylogenetic relationships showed that most of the betaherpesviruses sequences fell into a well-supported unique monophyletic clade and support the recognition of a new betaherpesvirus genus. This clade is subdivided into three major clades, corresponding to the families of bats studied. This supports the hypothesis of a species-specific parallel evolution process between the potentially new betaherpesviruses and their bat hosts. Interestingly, two of the betaherpesviruses’ sequences detected in rhinolophid bats clustered together apart from the rest, closely related to viruses that belong to the Roseolovirus genus. This suggests a putative third roseolo lineage. On the contrary, no phylogenetic structure was detected among several potentially novel bat-hosted gammaherpesviruses found in the study. Remarkably, all of the possible novel bat herpesviruses described in this study are linked to a unique bat species.

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Section: Introductionmentioning

confidence: 99%

Identification of Novel Betaherpesviruses in Iberian Bats Reveals Parallel Evolution

et al. 2016

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“…that have been recently discovered in bats include astroviruses, adeno-associated viruses (AAVs), adenoviruses, herpesviruses, and polyomavirus (8,9,13,31,32,35,37,39,40,42,61,62,68). For example, it was recently reported that a newly identified adenovirus isolated from bat guano was capable of infecting various vertebrate cell lines, including those of humans, monkeys, dogs, and pigs (35).…”

mentioning

confidence: 99%

Bat Guano Virome: Predominance of Dietary Viruses from Insects and Plants plus Novel Mammalian Viruses

Victoria

Wang³

et al. 2010

J Virol

345

337

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Bats are hosts to a variety of viruses capable of zoonotic transmissions. Because of increased contact between bats, humans, and other animal species, the possibility exists for further cross-species transmissions and ensuing disease outbreaks. We describe here full and partial viral genomes identified using metagenomics in the guano of bats from California and Texas. A total of 34% and 58% of 390,000 sequence reads from bat guano in California and Texas, respectively, were related to eukaryotic viruses, and the largest proportion of those infect insects, reflecting the diet of these insectivorous bats, including members of the viral families Dicistroviridae, Iflaviridae, Tetraviridae, and Nodaviridae and the subfamily Densovirinae. The second largest proportion of virus-related sequences infects plants and fungi, likely reflecting the diet of ingested insects, including members of the viral families Luteoviridae, Secoviridae, Tymoviridae, and Partitiviridae and the genus Sobemovirus. Bat guano viruses related to those infecting mammals comprised the third largest group, including members of the viral families Parvoviridae, Circoviridae, Picornaviridae, Adenoviridae, Poxviridae, Astroviridae, and Coronaviridae. No close relative of known human viral pathogens was identified in these bat populations. Phylogenetic analysis was used to clarify the relationship to known viral taxa of novel sequences detected in bat guano samples, showing that some guano viral sequences fall outside existing taxonomic groups. This initial characterization of the bat guano virome, the first metagenomic analysis of viruses in wild mammals using second-generation sequencing, therefore showed the presence of previously unidentified viral species, genera, and possibly families. Viral metagenomics is a useful tool for genetically characterizing viruses present in animals with the known capability of direct or indirect viral zoonosis to humans.

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“…Alpha-, beta-and gammaherpesviruses have all been discovered in bats. Using PCR, Wibbelt et al (94), Molnar et al (56), and Watanabe et al (93) discovered gamma-and betaherpesviruses in bats. Fifteen alphaherpesviruses were isolated from bats in Cambodia and Madagascar (65), and a betaherpesvirus (bat betaher-aligned.…”

mentioning

confidence: 99%

A Novel Bat Herpesvirus Encodes Homologues of Major Histocompatibility Complex Classes I and II, C-Type Lectin, and a Unique Family of Immune-Related Genes

Zhang

Todd

Tachedjian

et al. 2012

J Virol

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Detection of a new bat gammaherpesvirus in the Philippines

Cited by 32 publications

References 9 publications

Identification of Novel Betaherpesviruses in Iberian Bats Reveals Parallel Evolution

Identification of Novel Betaherpesviruses in Iberian Bats Reveals Parallel Evolution

Bat Guano Virome: Predominance of Dietary Viruses from Insects and Plants plus Novel Mammalian Viruses

A Novel Bat Herpesvirus Encodes Homologues of Major Histocompatibility Complex Classes I and II, C-Type Lectin, and a Unique Family of Immune-Related Genes

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