The echocardiographic diagnosis of a left atrial myxoma is described. This was later confirmed by cardiac catheterization and the tumor removed at operation. The myxoma was found to arise from the free left atrial wall and no such case diagnosed by echocardiography has previously been reported. The possibility of false negative and false positive echocardiographic findings is discussed. Echocardiography is an accurate, atraumatic, and rapid diagnostic technique which can be used as a simple screening procedure in cardiac evaluations. Left atrial myxoma is a life-threatening disease which is curable if diagnosed and treated appropriately. Though it is considered a rare, benign, intracavitary tumor, there is evidence that it is not as uncommon as once thought ( 1 ) and its clinical course can be rapidly fatal (2). As recently as 1951, the preoperative diagnosis of left atrial myxoma was considered very rare ( 3 ) . Angiography was first utilized in the clinical diagnosis in 1951 ( 4 ) , and is the definitive preoperative study. However, it is by no means benign, especially in the case of an unsuspected left atrial tumor. It constitutes a significant expense and inconvenience if used routinely as a screening procedure.The echocardiographic diagnosis of a left atrial tumor was first described in 1959 (5) in the German literature; however, it was not until 1968 that it first was reported in the American literature (6). Only 1 7 separate cases of intraatrial tumors detected by echocardiography have been reported to date (5-1 7). Eleven cases were diagnosed before cardiac catheterization; three after catheterization and three were not considered to have diagnostic echocardiograms. Fifteen were located in the left atrium and two in the right atrium. Of the left atrial myxomas, all were attached to the interatrial septum. In a review by Goodwin (18) of 45 patients with left atrial myxoma, the tumors all arose from the atrial septum in the region of the foss ovalis. Similar observations were also made by Pritchard ( 3 ) , Nasser (16), Heath (19) and Greenwood (20). The purpose of this communication is to illustrate the successful preoperative echocardiographic diagnosis of a left atrial myxoma which was later confirmed by cineangiography and removed at surgery. This myxoma was found to arise from the left atrial wall and not the interatrial septum. We believe this t o be the first echocardiographic detection of such a tumor.