Detection limits of different approaches in behavioral teratology, and correlation of effects with neurochemical parameters

Elsner, J; Hodel, Beat; Suter, K E; Oelke, Dieter; Ulbrich, Beate; Schreiner, G; Cuomo, V.; Cagiano, R.; Rosengren, Lars; Karlsson, Jan; Haglid, Kenneth G.

doi:10.1016/0892-0362(88)90080-3

Cited by 43 publications

(22 citation statements)

References 18 publications

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“…Included among these effects are impaired sensory function in nonhuman primates (Rice, 1996;Gilbert, 1982, 1990), retarded behavior in transition in rodents and nonhuman primates (Newland et al, 2004;Newland et al, 1994;Paletz et al, 2006), deficits in complex, high-rate operant behavior (Newland and Rasmussen, 2000), disrupted performance on timing in fixed-interval schedules of reinforcement (Rice, 1992), delayed object permanence (Burbacher et al, 1988;Gunderson et al, 1988b), and impaired facial recognition (Gunderson et al, 1988a). Performance on tasks that tap memory function, however, are relatively spared after developmental MeHg exposure (Elsner et al, 1988;Gilbert et al, 1993;Goldey et al, 1994;Newland and Paletz, 2000). This behavioral toxicity is consistent with damage to the cerebral cortex, a region that is especially susceptible to lowlevel developmental MeHg exposure.…”

Section: Introductionmentioning

confidence: 99%

Spatial and visual discrimination reversals in adult and geriatric rats exposed during gestation to methylmercury and n−3 polyunsaturated fatty acids

et al. 2007

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Fish contain essential long chain polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA), an omega-3 (or n-3) PUFA, but are also the main source of exposure to methylmercury (MeHg), a potent developmental neurotoxicant. Since n-3 PUFAs support neural development and function, benefits deriving from a diet rich in n-3s have been hypothesized to protect against deleterious effects of gestational MeHg exposure. To determine whether protection occurs at the behavioral level, female Long-Evans rats were exposed, in utero, to 0, 0.5, or 5 ppm of Hg as MeHg via drinking water, approximating exposures of 0, 40, and 400 μg Hg/kg/day and producing 0, 0.29, and 5.50 ppm of total Hg in the brains of siblings at birth. They also received pre-and postnatal exposure to one of two diets, both based on the AIN-93 semipurified formulation. A "fish-oil" diet was high in, and a "coconut-oil" diet was devoid of, DHA. Diets were approximately equal in α-linolenic acid and n-6 PUFAs. As adults, the rats were first assessed with a spatial discrimination reversal (SDR) procedure and later with a visual (nonspatial) discrimination reversal (VDR) procedure. MeHg increased the number of errors to criterion for both SDR and VDR during the first reversal, but effects were smaller or nonexistent on the original discrimination and on later reversals. No such MeHg-related deficits were seen when the rats were retested on SDR after two years of age. These results are consistent with previous reports and hypotheses that gestational MeHg exposure produces perseverative responding. No interactions between Diet and MeHg were found, suggesting that n-3 PUFAs do not guard against these behavioral effects. Brain Hg concentrations did not differ between the diets, either. In geriatric rats, failures to respond were less common and response latencies were shorter for rats fed the fish oil diet, suggesting that exposure to a diet rich in n-3s may lessen the impact of age-related declines in response initiation.

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Section: Introductionmentioning

confidence: 99%

Spatial and visual discrimination reversals in adult and geriatric rats exposed during gestation to methylmercury and n−3 polyunsaturated fatty acids

et al. 2007

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“…The first Behavioral Teratology (BT) collaborative study for standardizing methodologies 45,46,49,50) 1985-1988 European interlaboratory collaborative study to assess sensitivity of procedures [53][54][55] 1992-1995 The second Behavioral Teratology (BT) collaborative study for setting up a core battery 47,48,51,52) 1995 IPCS (International Programme on Chemical Safety) interlaboratory study for evaluating test validity, reliability, and measurement validity [56][57][58][59][60][61][62] 2000 ILSI workshop on DNT testing Similar projects were also conducted in our country since the Japanese Teratology Society established the Behavioral Teratology Meeting (BTM) as a satellite organization of the society in 1982 16,45,46) . The BTM led a series of Japanese collaborative studies for selecting and standardizing the reliable testing methodologies for correct identifications of behavioral teratogenicity of several known neurotoxicants during 1984-1986 and during 1992-1995 16,[45][46][47][48][49][50][51][52] .…”

Section: -1986mentioning

confidence: 99%

Developmental Neurotoxicology: History and Outline of Developmental Neurotoxicity Study Guidelines

Aoyama¹,

Takahashi²,

Shutoh³

et al. 2015

Food Safety

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The present work provides a brief review of basic concepts in developmental neurotoxicology, as well as current representative testing guidelines for evaluating developmental neurotoxicity (DNT) of xenobiotics. Historically, DNT was initially recognized as a "functional" teratogenicity: the main concern was that prenatal and/or early postnatal exposures to chemicals during critical periods of central nervous system (CNS) development would cause later functional abnormalities of the brain. Current internationally harmonized DNT study guidelines are thus intended to predict adverse effects of test compounds on the developing CNS by observing such postnatal parameters as motor activity, startle response, and learning and memory, as well as neuropathological alterations. The reliability of current DNT study guidelines and sensitivity of testing methodologies recommended in these guidelines have been confirmed by retrospective evaluations of the many international and domestic collaborative validation studies in developed nations including Japan.

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“…Adams (1982) and Adams et al (1983) were among the first reports which examined the possibility that rat pup isolation-or cold-induced UVs might be a sensitive indicator of teratologic effects. Within the last 10 years, the effects of 4-9 prenatal exposure to haloperidol (Cagiano, Barfield, White, et al, 1988), diazepam (Cagiano, DeSalvia, Persichella, et al, 1990), methyl mercury Cagiano, Cortese, DeSalvia et al, 1988;Eisner et al, 1988Eisner et al, , 1990, flumazenil (Cagiano, DeSalvia, Giustino, et al, 1993), and ethanol (Kehoe & Shoemaker, 1991) have been examined using UVs as a dependent measure.…”

Section: )mentioning

confidence: 99%

USAF Summer Research Program - 1994 Summer Faculty Research Program Final Reports, Volume 2A, Armstrong Laboratory.

Moore¹

1994

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Detection limits of different approaches in behavioral teratology, and correlation of effects with neurochemical parameters

Cited by 43 publications

References 18 publications

Spatial and visual discrimination reversals in adult and geriatric rats exposed during gestation to methylmercury and n−3 polyunsaturated fatty acids

Spatial and visual discrimination reversals in adult and geriatric rats exposed during gestation to methylmercury and n−3 polyunsaturated fatty acids

Developmental Neurotoxicology: History and Outline of Developmental Neurotoxicity Study Guidelines

USAF Summer Research Program - 1994 Summer Faculty Research Program Final Reports, Volume 2A, Armstrong Laboratory.

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