Detection, Isolation and Confirmation of Crimean-Congo Hemorrhagic Fever Virus in Human, Ticks and Animals in Ahmadabad, India, 2010–2011

Mourya, Devendra T.; Yadav, Pragya D; Shete, Anita M.; Gurav, Yogesh K.; Raut, Chandrashekhar G.; Jadi, Ramesh; Pawar, Shailesh D.; Nichol, Stuart T.; Mishra, Akhilesh C.

doi:10.1371/journal.pntd.0001653

Cited by 96 publications

(81 citation statements)

References 14 publications

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“…In early 2011, the first cases of CCHF were identified in India, in a nosocomial outbreak in Gujarat state, which adjoins Pakistan (Mishra et al, 2011). A recent serosurvey and sampling of H. anatolicum ticks showed that infection was present in local livestock (Mourya et al, 2012).…”

Section: Cchf In Eastern and Central Asiamentioning

confidence: 99%

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

et al. 2013

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Bente, Dennis A.; Forrester, Naomi L.; Watts, Douglas M.; McAuley, Alexander J.; Whitehouse, Chris A.; and Bray, Mike, "CrimeanCongo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity" (2013 b s t r a c tCrimean-Congo hemorrhagic fever (CCHF) is the most important tick-borne viral disease of humans, causing sporadic cases or outbreaks of severe illness across a huge geographic area, from western China to the Middle East and southeastern Europe and throughout most of Africa. CCHFV is maintained in vertical and horizontal transmission cycles involving ixodid ticks and a variety of wild and domestic vertebrates, which do not show signs of illness. The virus circulates in a number of tick genera, but Hyalomma ticks are the principal source of human infection, probably because both immature and adult forms actively seek hosts for the blood meals required at each stage of maturation. CCHF occurs most frequently among agricultural workers following the bite of an infected tick, and to a lesser extent among slaughterhouse workers exposed to the blood and tissues of infected livestock and medical personnel through contact with the body fluids of infected patients. CCHFV is the most genetically diverse of the arboviruses, with nucleotide sequence differences among isolates ranging from 20% for the viral S segment to 31% for the M segment. Viruses with diverse sequences can be found within the same geographic area, while closely related viruses have been isolated in far distant regions, suggesting that widespread dispersion of CCHFV has occurred at times in the past, possibly by ticks carried on migratory birds or through the international livestock trade. Reassortment among genome segments during co-infection of ticks or vertebrates appears to have played an important role in generating diversity, and represents a potential future source of novel viruses. In this article, we first review current knowledge of CCHFV, summarizing its molecular biology, maintenance and transmission, epidemiology and geographic range. We also include an extensive discussion of CCHFV genetic diversity, including maps of the range of the virus with superimposed phylogenetic trees. We then review the features of CCHF, including the clinical syndrome, diagnosis, treatment, pathogenesis, vaccine development and laboratory animal models of CCHF. The paper ends with a discussion of the possible future geographic range of the virus. For the benefit of researchers, we include a Supplementary Table listing all published reports of CCHF cases and outbreaks in the English-language literature, plus some principal articles in other languages, with total case numbers, case fatality rates and all CCHFV strains on GenBank.

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Section: Cchf In Eastern and Central Asiamentioning

confidence: 99%

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

et al. 2013

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“…In this context, it will be an invaluable new tool in studying specific antibody responses induced by the many novel CCHFV vaccine candidates currently undergoing research and development (5,24,25). It is known that CCHFV infects various wild and domestic animals, such as cattle, sheep, goats, buffalo, hares, squirrels, mice, rats, and hedgehogs (26)(27)(28)(29). While further studies are necessary before utilizing the assay for animal sera, the neutralization assay reported in this study does have potential as a sero-epidemiological tool that can be used to accurately detect CCHFV infections in animals.…”

Section: Resultsmentioning

confidence: 99%

The Development of a Novel Diagnostic Assay That Utilizes a Pseudotyped Vesicular Stomatitis Virus for the Detection of Neutralizing Activity against Crimean-Congo Hemorrhagic Fever Virus

et al. 2018

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SUMMARY:Crimean-Congo hemorrhagic fever virus is a risk group 4 pathogen, which mandates the use of maximum containment facilities, often termed biosafety level 4 or containment level 4 when working with infectious materials. Diagnostic and research work involving live viruses in such laboratories is timeconsuming and inconvenient, resulting in delays. Herein, we show that serum neutralizing activity against the virus can be measured in low-containment laboratories using a pseudotyped virus.

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“…In this outbreak among 76 reported cases, four human deaths were occurred in which the first death was of a 32-year old housewife on 3 rd January, 2011 in a Korat village of Sanand, and on 13 th January, 2011 a 35-year old doctor treating her died, and on 18 th January, 2011 an accompanying nurse also died (Mourya et al, 2012). The following villages were affected seriously during outbreak of CCHF in Gujarat -Moraiya (13 cases), Shela (6 cases), Changodhar (23 cases), Navapur-Vaghajipuar (13 cases), Dholeshwar (5 cases), Kolat (9 cases), Motidevti (1 case) and Telav (6 cases) (Ministry of Health and Family Welfare, 2011).…”

Section: Epidemiologymentioning

confidence: 94%

“…Rodent samples were also sent to the HSADL laboratory in Bhopal. The CCHF virus was found in high quantities in ticks (Mourya et al, 2012). National Centre for Disease Control, New Delhi developed the polymerase chain reaction (PCR) primers for the testing of the samples.…”

Section: Epidemiologymentioning

confidence: 99%

An Emerging Threat of Crimean Congo Hemorrhagic Fever: Call for Preparedness

Goswami¹

2014

Adv. Anim. Vet. Sci.

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Detection, Isolation and Confirmation of Crimean-Congo Hemorrhagic Fever Virus in Human, Ticks and Animals in Ahmadabad, India, 2010–2011

Cited by 96 publications

References 14 publications

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

The Development of a Novel Diagnostic Assay That Utilizes a Pseudotyped Vesicular Stomatitis Virus for the Detection of Neutralizing Activity against Crimean-Congo Hemorrhagic Fever Virus

An Emerging Threat of Crimean Congo Hemorrhagic Fever: Call for Preparedness

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