Detection: From Electrochemistry to  Spectroscopy with Chromatographic  Techniques, Recent Trends with  Nanotechnology

Saleh, Tawfik A.

doi:10.4236/detection.2014.24005

Cited by 16 publications

(1 citation statement)

References 32 publications

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“…NPs have two or three dimensions in the size range of 1 to 100 nm. They are of various types based on their size, shape, and composition [18]. Their higher surface area built them as suitable drug career, which has the capability to immobilize the compounds on their surface to increase their solubility and targeted delivery [19].…”

Section: Nanoparticles (Nps) As Antibiofilm Agentsmentioning

confidence: 99%

Approaches to Enhance Therapeutic Activity of Drugs against Bacterial Biofilms

Sankar¹,

Mahipriya²

2022

Focus on Bacterial Biofilms

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Biofilm may be a consortium of microbial species where the cells of microbes attach to both life form and inanimate surfaces inside a self-made matrix of extracellular polymeric substance (EPS). Biofilm matrix surrounding the polymicrobial environment makes them highly resistant to harsh conditions and antibacterial treatments. The two significant factors that differentiate planktonic from biofilm resident microbes are EPS containing a variety of macromolecules and a diffusible molecule for transferring signals known as quorum sensing (QS). Against this backdrop of microbial resistance and cell signaling, different approaches have been developed to interfere with the specific mechanisms of intracellular and extracellular targets that include herbal active compounds and synthetic nanoparticles. This chapter outlines the features of biofilm development and the approaches with the evidence that can be incorporated into clinical usage.

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Section: Nanoparticles (Nps) As Antibiofilm Agentsmentioning

confidence: 99%