Detection Dicyandiamide in Environmental Water by Liquid Chromatography–Mass Spectrometry Combined with Solid Phase Extraction Method

Abstract

A new analytical method has been developed to determine dicyandiamide in environmental water. Residues of dicyandiamide were extracted from the environmental water samples by solid phase extraction using Waters Sep-Pak AC2 Cartridge. The extraction procedure condition (included loading, washing, and eluting) of flow rate of 1.0 mL=min, and dicyandiamide was eluted with 20 mL of acetonitrile and methanol (v=v ¼ 60:40) mixture solution, and preconcentrated using nitrogen evaporation followed by analysis with liquid chromatography-mass spectrometry. Laboratory method validation data was collected in water samples at concentration down to 1.0 ng=mL. Average recovery and relative standard deviation using spiked calibration standard curve were 89% and 2.9%, respectively. The method provides a effective approach to monitor the contaminant in environmental water samples.

Quantitation of guanidine derivatives as representative persistent and mobile organic compounds in water: method development

“…AC2 has been previously used to enrich very polar compounds in water, e.g., 1,4-dioxane [ 42 , 43 ] and N -nitrosodimethylamine [ 44 ]. As a polar compound, CG is also strongly retained by AC2 when an appropriate eluent is used [ 36 , 37 ]. When acetonitrile:methanol (3:2) was used as the eluent, CG was retained by AC2 with a recovery of 94% (Fig.…”

“…CG was only slightly retained on AC2 (ESM Table S 3 , AC2 protocol 1) under the initially investigated protocols. Therefore, two additional solvents were examined as AC2 eluents (ESM Table S 3 , AC2 protocols 2 and 3) based on previous studies [ 36 , 37 ].…”