Detection by ion-pairing probes in reversed-phase liquid chromatography

Hackzell, L.; Schill, G

doi:10.1007/bf02261604

Cited by 91 publications

(14 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The retention time of the system peak depends only on the properties of the chromatographic system and is independent of the nature of the analyte, whereas its direction changes with the injected sample composition. A mobile phase component gives a system peak, which can be recognized by injection of the pure mobile phase solvent [22]. It is evident that the orientation of the analyte peak depends on the analyte charge and its retention relative to the added system compound.…”

Section: Indirect Detectionmentioning

confidence: 99%

“…When the mobile phase contains unknown impurities, problems of indirect detection may occur [57]. Moreover, particularly large system peaks appear if the mobile phase gives a detector response itself and the injected sample is dissolved in a different solvent [22,56,58]. Indirect detection is a sensitive method for visualization of all kinds of compounds and can be combined with any sensitive and stable detector.…”

Section: Indirect Detectionmentioning

confidence: 99%

See 1 more Smart Citation

System peaks and their positive and negative aspects in chromatographic techniques

Srbek

Coufal²,

Bosáková

et al. 2005

J of Separation Science

View full text Add to dashboard Cite

Whenever a mobile phase contains more than one component, additional signals commonly called system peaks can appear. The origin of these signals is explained through loss of equilibrium in the separation column caused by injection of analyte dissolved in a different solvent than the mobile phase. The system peaks are then generated by a relaxation process started by the non-equilibrium state. An overview of the theory and applications of the system peaks in separation methods, mainly in liquid chromatography, is presented in this paper. Only a brief theoretical discussion of the system peak origin is given as the theoretical aspects of system peak formation have already been published in many papers. The main focus of this review is to summarize applications, in which system peaks were used to measure physical or physicochemical data. Signals of system peaks are often misinterpreted but they offer valuable information about thermodynamics and kinetics of the separation process that takes place in chromatographic column.

show abstract

Section: Indirect Detectionmentioning

confidence: 99%

Section: Indirect Detectionmentioning

confidence: 99%

System peaks and their positive and negative aspects in chromatographic techniques

Srbek

Coufal²,

Bosáková

et al. 2005

J of Separation Science

View full text Add to dashboard Cite

show abstract

“…This result in desorption of some additive molecule migrating along the column to generate system peak. System peak also termed as pseudo peak, ghost peak, eigenpeak, vacancy peak, induced peak, dip peak, or perturbation peak has been studied since 1970s [34][35][36][37][38][39][40][41][42][43][44]. Levin and Grushka realized the system peaks were produced in relaxation process to a new state of equilibrium [41].…”

Section: Introductionmentioning

confidence: 98%

Characterization of warfarin unusual peak profiles on oligoproline chiral high performance liquid chromatography columns

Lao

Gan

2010

Journal of Chromatography A

View full text Add to dashboard Cite

“…A general and sensitive detection technique, usually called indirect detection, can be based on the ion-pair distribution principle in reversed phase systems (Denkert et al, 1981;Hackzell and Schill, 1982;Rydberg et al, 1983). A UV-absorbing or fluorescent ion is included in the mobile phase and distributed to the hydrophobic adsorbent that is used as stationary phase.…”

Section: Problems Caused By Flow Of Formulationsmentioning

confidence: 99%

Directed Drug Delivery

Borchardt¹,

Repta²,

Stella³

1985

View full text Add to dashboard Cite

All rights reservedNo part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. PREFACEThis book is based on the proceedings of the symposium entitled "Directed Drug Delivery: A Multidisciplinary Problem," which was held in Lawrence, Kansas on October 17-19, 1984. The purpose of the symposium and this book is to focus on the multidisciplinary nature of drug delivery. Development of a successful drug delivery system requires contributions from various scientific disciplines, including pharmaceutical chemistry, analytical chemistry, medicinal chemistry, biochemistry, pharmacology, toxicology, and clinical medicine. The contents of this volume illustrate the importance of the various disciplines in identifying the problems and approaches for the development of a rational and effective drug delivery system. Thus the information provided herein will be of value not only to the pharmaceutical chemists who are responsible for dosage form design, but also to the pharmacokineticists, pharmacologists, and clinicians involved in biological evaluation of drug delivery systems. The volume should also be of interest to the analytical chemists who must provide technology to quantitcltively evaluate drug delivery. Additionally, this work will also interest the biochemists and medicinal chemists involved in drug discovery, since the drug delivery system often plays a major role in determining the success or failure of a new drug entity.Each speaker at the symposium was requested to contribute a chapter reviewing the contribution of their major discipline to the development of a successful drug delivery system. Topics covered in this volume include pharmacokinetics and pharmacodynamic factors (Section A) and physiological and biochemical factors (Section B) that influence directed drug delivery, various approaches to controlled and targeted drug delivery, including physical (SectionC) and biological (Section D) systems, as well as appropriate and important analytical chemistry topics (Section E).The individual chapters in this volume represent comprehensive, up-to-date reviews of the subject material. However, to gain maximum appreciation for the multidisciplinary nature of drug delivery, the editors suggest a thorough reading of the entire volume.

show abstract

Detection by ion-pairing probes in reversed-phase liquid chromatography

Cited by 91 publications

References 15 publications

System peaks and their positive and negative aspects in chromatographic techniques

System peaks and their positive and negative aspects in chromatographic techniques

Characterization of warfarin unusual peak profiles on oligoproline chiral high performance liquid chromatography columns

Directed Drug Delivery

Contact Info

Product

Resources

About