Detection by DNA polymerase I of breaks produced in rat liver chromatin in vivo by alklating agents

Saffhill, Roy; Cooper, Helen K.; Itzhaki, Ruth F.

doi:10.1038/248153a0

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Mechanisms Of Action Of Anricancer Drugs1

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1975

1985

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Cited by 15 publications

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“…For example, by interacting with the phosphodiester back-bone, carcinogenic compounds decrease the negative charge of DNA, this may in turn influence the binding of chromatin protein to DNA (60). The interaction also alters the helical structure of DNA, inducing conformational changes (61,62). Some carcinogens may induce single-or double-strand breaks, binding by hydrogen bonding and causing local destabilization or cross-linking of the two strands of the DNA duplex (63)(64)(65)(66).…”

Section: Mechanisms Of Action Of Anricancer Drugsmentioning

confidence: 99%

Carcinogenicity of Some Anticancer Drugs—a Survey

Lien

1985

J Clin Pharm Ther

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A list of 37 anticancer drugs with reported carcinogenicity or co‐carcinogenicity has been compiled. These drugs include 16 alkylating agents, eight antimetabolites, four antibiotics, four hormones, one alkaloid, and four miscellaneous drugs. The reported carcinogenicity of these drugs in model systems and their possible mechanisms of action are reviewed together with structure‐carcinogenicity relationships. These drugs have been reported to cause cancers in different sites in various test animals. Most of these drugs react with DNA, and the ultimate reactive forms of the drugs are electrophiles.

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