Detection and Treatment of Vulnerable Plaques and Vulnerable Patients

Waxman, Sergio; Ishibashi, Fumiyuki; Muller, James E.

doi:10.1161/circulationaha.105.540013

Cited by 195 publications

(116 citation statements)

References 255 publications

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“…Microbubble contrast agents are miniature gas bubbles, which can remain suspended in the circulation for an extended period. During scanning the energy produced by the ultrasound beam causes rapid contraction and expansion of the bubble leading to contrast enhancement [66].…”

Section: Ultrasonographymentioning

confidence: 99%

Nanotechnology in Cancer Diagnosis and Treatment

El-Karim¹,

El-Zahar²,

Anwar³

2015

JPP

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Nanotechnology refers to research and technology development at the atomic, molecular, and macromolecular scale, leading to the controlled manipulation and study of structures and devices with length scales in the 1-100 nanometers range. Objects at this scale, such as "nanoparticles," take on novel properties and functions that differ markedly from those seen in the bulk scale. The small size, surface tailor ability, improved solubility, and multifunctional of nanoparticles open many new research avenues for biologists. Nanoparticles are classified into inorganic nanoparticles such as gold nanoparticles and organic nanoparticles such as carbon nanotubes and dendrimers. Different types of nanoparticals such as nanocrystals, liposomes, polymeric nanoparticles, dendrimers, quantum dots and superparamagnetic nanoparticles illustrated different examples of promising nanoparticles for cancer treatment and imaging.

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Section: Ultrasonographymentioning

confidence: 99%

Nanotechnology in Cancer Diagnosis and Treatment

El-Karim¹,

El-Zahar²,

Anwar³

2015

JPP

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“…Eventually, we will need better imaging techniques that can assess both plaque burden (soft and calcified) and the extent of vulnerable plaques. These techniques will require molecular imaging that permit delineation of plaque macrophage density and inflammatory markers, the thickness of the fibrous cap, the extent of the lipid-laden necrotic core, fibrin deposition, and the presence of neovessels (Davies et al, 2004;Jaffer et al, 2006;Waxman et al, 2006). If total plaque burden and some index of "vulnerability" could be detected noninvasively, at a reasonable cost, then this approach may be preferable to plaque coronary artery calcium imaging, which is merely reflective of the presence of atherosclerosis.…”

Section: What Are the Implications Of An Early Diagnosis Of Coronary mentioning

confidence: 99%

Detection of Silent Ischemia in Patients with Type 2 Diabetes

Emilia¹,

Vlad²

2011

Recent Advances in the Pathogenesis, Prevention and Management of Type 2 Diabetes and Its Complications

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“…Identifying a coronary plaque that is usually associated with a higher risk of rupture or erosion would possibly help us to establish more aggressive treatment to prevent the genesis of the pathophysiology of the ACS. However, the best way to establish this treatment (locally or systemically) still remains highly controversial [3,5].…”

Section: Introductionmentioning

confidence: 99%

“…Over the last several decades, the quest to identify and treat the 'vulnerable plaque' has generated much interest [7,8]. Different imaging techniques have been touted as being able to identify vulnerable plaques: thermography, Near Infrared Spectroscopy (NIRS), intravascular ultrasound, virtual histology, intracoronary optical coherence tomography and the "noninvasive", but also contrast and radiation demanding: coronary tomography [5].…”

Section: Introductionmentioning

confidence: 99%