Detection and quantification of lung cancer biomarkers by a micro-analytical device using a single metal oxide-based gas sensor

Gregis, Geoffrey; Sanchez, Jean-Baptiste; Bezverkhyy, Igor; Weber, G.; Berger, Franck; Fierro, Vanessa; Bellat, Jean-Pierre

doi:10.1016/j.snb.2017.08.056

Cited by 69 publications

(63 citation statements)

References 44 publications

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“…The comparison is shown in Table 2 . Furthermore, due to the miniaturization of the sensor size and the simplicity of resistance measurement, this kind of sensor would be easily integrated into a sensor array and a micro-preconcentrator to achieve better discrimination and sensitivity [ 3 , 21 , 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…The detection of VOCs in the environment or in exhaled breath has received considerable attention and is becoming increasingly important in the development of point of care testing (POCT) devices and Internet of Things (IoT) nodes [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. The development of versatile materials enables advances in gas sensors or electric nose detection.…”

Section: Introductionmentioning

confidence: 99%

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A Room Temperature VOCs Gas Sensor Based on a Layer by Layer Multi-Walled Carbon Nanotubes/Poly-ethylene Glycol Composite

Liu

Yang

Dong

et al. 2018

Sensors

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Sensitive detection of volatile organic compounds (VOCs) is significant for environmental monitoring and medical applications. In this work, multi-walled carbon nanotubes (MWCNTs) and polyethylene glycol (PEG) that have good adsorption for VOCs, were sprayed layer by layer on an interdigitated electrode (IDE) to build a sensitive VOCs gas sensor. The relative resistance change (△R/R) when the sensor was exposed to VOCs was measured. The sensor showed high sensitivity to acetone, ethanol, isopropanol and isoprene with fast response (110 ± 5 s) and recovery (152 ± 5 s) at room temperature, and the lower detection limit (LDL) of the sensor reached 9 ppm. With the micro-fabricated IDE structure, the sensor can be easily built into an electric nose for VOC recognition and measurement.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Room Temperature VOCs Gas Sensor Based on a Layer by Layer Multi-Walled Carbon Nanotubes/Poly-ethylene Glycol Composite

Liu

Yang

Dong

et al. 2018

Sensors

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“…These miniaturized GC were conceived for a wide variety of applications requiring very sensitive instruments such as environmental monitoring [20], [35], early cancer diagnosis [23], [36] or food quality control [37]. Therefore, all GC systems include a preconcentrator that improves the detector sensitivity to tens or hundreds of ppb in the case of sensors and, to ppb or even hundreds of ppt in the case of PID detectors.…”

Section: Comparison With the Existing Instrumentsmentioning

confidence: 99%

Easy-to-manufacture micro gas preconcentrator integrated in a portable GC for enhanced trace detection of BTEX

Rodríguez-Cuevas

Lara-Ibeas

Leprince

et al. 2020

Sensors and Actuators B: Chemical

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Air pollution is a current environmental and global public health issue, which requires technological developments to monitor airborne pollutants such as Volatile Organic Compounds (VOCs). These organic species are dangerous for humans even at trace levels. In this regard, an analytical device can be advantageously coupled with a preconcentration system to improve its sensitivity. In this context, a novel preconcentrator was conceived, manufactured, and tested inside an existing portable gas chromatograph (GC). With a very limited gas sample of 20 mL, the limits of detection achieved are 0.057, 0.150, 0.368, 0.396, 0.418 ppb for benzene, toluene, ethylbenzene, m-/pxylenes and o-xylene, respectively. These values enable the system to monitor air quality even in the environments with the strictest regulation (0.6 ppb for benzene). Besides, the comparison with the literature demonstrates that the present analytical device is from two to three orders of magnitude more sensitive than the previous ones when detection limit is expressed in pg. The repeatability and reproducibility experiments show that the measurements are reliable and stable over time, while maintaining a reasonable time resolution of 19 min which can be easily reduced to 15 min by a full automation. Moreover, the average power consumption of the system was limited to 61 W allowing the system to work autonomous and battery powered. Finally, this preconcentrator can be conveniently fabricated without the need for a cleanroom and the simplicity of the design provides an easy way to replace the adsorbent broadening the range of VOC that can be detected.

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“…The abnormal level of EBM carries some information about the disease status and treatment efficiency (Das & Pal, 2020). Many clinical trials focused on EBM for the diagnosis of disease ranging from respiratory, diabetes to cancer (Brinkman et al, 2020; Chang et al, 2018; Gregis et al, 2018; Kabir et al, 2019; Rahman et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Metal oxide‐based gas sensors for the detection of exhaled breath markers

2021

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Exhaled breath test is a typical disease monitoring method for replacing of blood and urine samples that may create discomfort for patients. To monitor exhaled breath markers, gas biomedical sensors have undergone rapid progresses for non‐invasive and point‐of‐care diagnostic devices. Among gas sensors, metal oxide‐based biomedical gas sensors have received remarkable attentions owing to their unique properties, such as high sensitivity, simple fabrication, miniaturization, portability, and real‐time monitoring. Herein, we reviewed the recent advances in chemoresistive metal oxide‐based gas sensors with ZnO, SnO 2 , and In 2 O 3 as sensing materials for monitoring a range of exhaled breath markers (i.e., NO, H 2 , H 2 S, acetone, isoprene, and formaldehyde). We focused on the strategies that improve the sensitivity and selectivity of metal oxide‐based gas sensors. The challenges to fabricate a functional gas sensor with high sensing performance along with suggestions are outlined.

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Detection and quantification of lung cancer biomarkers by a micro-analytical device using a single metal oxide-based gas sensor

Cited by 69 publications

References 44 publications

A Room Temperature VOCs Gas Sensor Based on a Layer by Layer Multi-Walled Carbon Nanotubes/Poly-ethylene Glycol Composite

A Room Temperature VOCs Gas Sensor Based on a Layer by Layer Multi-Walled Carbon Nanotubes/Poly-ethylene Glycol Composite

Easy-to-manufacture micro gas preconcentrator integrated in a portable GC for enhanced trace detection of BTEX

Metal oxide‐based gas sensors for the detection of exhaled breath markers

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