Detection and Prevention of Drug–Drug Interactions in the Hospitalized Elderly: Utility of New Cytochrome P450–Based Software

The burden and management of cytochrome P450 2D6 (CYP2D6)‐mediated drug–drug interaction (DDI): co‐medication of metoprolol and paroxetine or fluoxetine in the elderly

“…Third, we did not obtain information on the patients' entire drug regimen. Elderly patients with polypharmacy may be prescribed other drugs affecting two or more CYP enzymes, thus requiring a more advanced recommendation . Fourth, we did not have information about each patient's CYP2D6 genotype and phenotype.…”

“…The role of DDI alerts in minimizing DDI has been documented . However, the DDI alert system has some drawbacks, such as the ‘alert fatigue phenomenon’ which leads to failure to act on alerts .…”

Drug-Drug Interactions and Acute Kidney Injury: Caveat Prescriptor

“…20 InterMED-Rx is a software program designed to identify CYP450 drug-drug interactions; its implementation was reported to identify elderly patients at risk for drug-drug interactions. 21 …”

“Drugs on oxygen”: an update and perspective on the role of cytochrome P450 testing in pharmacology

“…Similarly, the successful application of QSAR is currently restricted to ligand-based approaches that complement already existent experimental data sets [43]. Efforts to extend QSAR to predict DDI during cancer therapy or polypharmacy have shown some promise but found the method to be over-predictive [44,45]. …”