Detection and prevalence of Capnocytophaga in periodontal Health and disease

Pudakalkatti, Pushpa S; Baheti, Abhinav S; Hattarki, Sanjeevini A; Kambali, Soumya; Naik, Reshma

doi:10.4103/0975-8844.195911

Cited by 6 publications

(2 citation statements)

References 4 publications

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“…It is not a highly abundant genus but its relative abundance in healthy samples is remarkably lower and in periodontitis, it almost disappears. This finding is in good agreement with Pudakalkatti et al, who described Capnocytophaga species to be the most prevalent in gingivitis (a transient state from a clinical point of view) rather than in healthy periodontium and periodontitis (Pudakalkatti et al, 2016). They also claimed that Capnocytophaga has the potential to cause periodontal disease, but as it is less competitive in the periodontal pocket, it is usually overgrown by other rapidly growing bacteria.…”

Section: Misclassification Of Samplessupporting

confidence: 89%

The Oral Microbiome in Periodontal Health

Lenartova

Tesinska

Janatová

et al. 2021

Front. Cell. Infect. Microbiol.

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The estimation of oral microbiome (OM) taxonomic composition in periodontally healthy individuals can often be biased because the clinically periodontally healthy subjects for evaluation can already experience dysbiosis. Usually, they are included just based on the absence of clinical signs of periodontitis. Additionally, the age of subjects is used to be higher to correspond well with tested groups of patients with chronic periodontitis, a disorder typically associated with aging. However, the dysbiosis of the OM precedes the clinical signs of the disease by many months or even years. The absence of periodontal pockets thus does not necessarily mean also good periodontal health and the obtained image of “healthy OM” can be distorted.To overcome this bias, we taxonomically characterized the OM in almost a hundred young students of dentistry with precise oral hygiene and no signs of periodontal disease. We compared the results with the OM composition of older periodontally healthy individuals and also a group of patients with severe periodontitis (aggressive periodontitis according to former classification system). The clustering analysis revealed not only two compact clearly separated clusters corresponding to each state of health, but also a group of samples forming an overlap between both well-pronounced states. Additionally, in the cluster of periodontally healthy samples, few outliers with atypical OM and two major stomatotypes could be distinguished, differing in the prevalence and relative abundance of two main bacterial genera: Streptococcus and Veillonella. We hypothesize that the two stomatotypes could represent the microbial succession from periodontal health to starting dysbiosis. The old and young periodontally healthy subjects do not cluster separately but a trend of the OM in older subjects to periodontitis is visible. Several bacterial genera were identified to be typically more abundant in older periodontally healthy subjects.

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Section: Misclassification Of Samplessupporting

confidence: 89%

The Oral Microbiome in Periodontal Health

Lenartova

Tesinska

Janatová

et al. 2021

Front. Cell. Infect. Microbiol.

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“…It can affect up to 80% of animals, where bacteria accumulate on dental surfaces with posterior damage and destruction of adjacent structures (Patel et al, 2016). The association of the genus Capnocytophaga with periodontal disease is controversial (Frandsen et al, 2008), however studies point to the genus as potential to cause gingivitis and periodontal disease in humans (Ciantar et al, 2005;Pudakalkatti et al, 2016;Kotrashetti et al 2020), besides acting in synergism with periodontitis-causing microorganisms in the formation of bacterial biofilms also in humans (Okuda et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Detection of Capnocytophaga canimorsus and Capnocytophaga cynodegmi in dogs with periodontal disease of Brazil

Nogueira

Martini

Menezes

et al. 2021

RSD

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Capnocytophaga canimorsus e Capnocytophaga cynodegmi são bacilos Gram-negativos encontrados na microbiota oral de cães e gatos capazes de infectar humanos através de mordidas, lambidas ou contato próximo aos animais. As manifestações clínicas vão desde inflamação local da lesão a sepse, podendo ser seguida por óbito em humanos. O objetivo do trabalho foi detectar C. canimorsus e C. cynodegmi em amostras de curetagem subgengival de cães domiciliados atendidos em um Hospital Veterinário Público no Brasil, através da técnica de PCR. De 121 amostras testadas, a prevalência de C. canimorsus foi de 19% e de C. cynodegmi foi de 66,94%. Houve associação significativa entre a presença de C. cynodegmi e doença periodontal avançada. Conclui-se que os microrganismos estão circulantes na microbiota oral de cães domiciliados do Brasil, o que representa um risco à saúde pública devido ao seu potencial zoonótico. Visto a falta de estudos sobre esses microrganismos no país, se faz necessária a realização de pesquisas para compreender a patogenia, manifestações clínicas, diagnóstico e tratamento de infecções por C. canimorsus e C. cynodegmi no Brasil, visando a Saúde Única.

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