Detection and monitoring of lung inflammation in cystic fibrosis during respiratory tract exacerbation using diffusion-weighted magnetic resonance imaging

Ciet, Pierluigi; Bertolo, Silvia; Ros, Mirco; Andrinopoulou, E.-R.; Tavano, V.; Lucca, Francesca; Feiweier, Thorsten; Krestin, Gabriël P.; Tiddens, Harm A.W.M.; Morana, Giovanni

doi:10.1183/13993003.01437-2016

Cited by 24 publications

(32 citation statements)

References 31 publications

(45 reference statements)

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“…Ciet et al . 34 reported that ADC value of inflammatory lesion significantly increased after intravenous antibiotic treatment compared with baseline in patients with cystic fibrosis admitted for respiratory tract exacerbations treatment.…”

Section: Discussionmentioning

confidence: 98%

Diffusion-weighted MRI in solitary pulmonary lesions: associations between apparent diffusion coefficient and multiple histopathological parameters

Feng

Zhou

Tang

et al. 2018

Sci Rep

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Apparent diffusion coefficient (ADC) from diffusion-weighted imaging (DWI) has gained wide attention as potential tool for differentiating between malignant and benign solitary pulmonary lesions (SPLs). The overall effects of multiple histopathological parameters on ADC have not been elucidated, which may help to explain the overlapping of ADC between malignant and benign SPLs. The study sought to explore associations between ADC and histopathological parameters in SPLs, and to compare diagnostic capability of ADC among different types of SPLs. Multiple histopathological parameters (cell density, nuclear-to-cytoplasm ratio, necrotic fraction, presence of mucus and grade of differentiation) were quantified in 52 malignant and 13 benign SPLs with surgical pathology available. Cell density (β = −0.40) and presence of mucus (β = 0.77) were independently correlated with ADC in malignant SPLs. The accurate diagnosis rate of squamous carcinomas, adenocarcinomas without mucus and malignant tumors with mucus was 100%, 82% and 0%, respectively. Our study suggested that cell density and presence of mucus are independently correlated with ADC in malignant SPLs. Squamous carcinoma maybe more accurately diagnosed as malignancy by ADC value. Malignant SPLs with mucus and adenocarcinomas with low cell density should be kept in mind in differentiating SPLs using ADC because of insufficient diagnostic capability.

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Section: Discussionmentioning

confidence: 98%

Diffusion-weighted MRI in solitary pulmonary lesions: associations between apparent diffusion coefficient and multiple histopathological parameters

Feng

Zhou

Tang

et al. 2018

Sci Rep

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“…MRI has already proven to be reliable in the evaluation of structural changes like bronchiectasis, wall thickening, mucus plugging, and infiltrates [126,[171][172][173] and novel sequences such as ultrashort or zero echo time and multiparametric-functional imaging are expected to provide additional information (Figure 3). Furthermore, scores based on Diffusion weighted imaging demonstrated to strongly correlate with the severity of the disease and the amount of mucus [174] as well as of being associated with symptoms scores, spirometry measurements and inflammation during disease's exacerbation [164,175,176]. Hyperpolarized gases such as 129Xe showed inhomogeneous ventilation patterns with areas of lacking ventilation in such patients [177].…”

Section: Magnetic Resonance Imaging (Mri) and Pet/mrimentioning

confidence: 98%

Molecular Imaging of Pulmonary Inflammation and Infection

Giraudo

Evangelista

Fraia

et al. 2020

IJMS

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Infectious and inflammatory pulmonary diseases are a leading cause of morbidity and mortality worldwide. Although infrequently used in this setting, molecular imaging may significantly contribute to their diagnosis using techniques like single photon emission tomography (SPET), positron emission tomography (PET) with computed tomography (CT) or magnetic resonance imaging (MRI) with the support of specific or unspecific radiopharmaceutical agents. 18F-Fluorodeoxyglucose (18F-FDG), mostly applied in oncological imaging, can also detect cells actively involved in infectious and inflammatory conditions, even if with a low specificity. SPET with nonspecific (e.g., 67Gallium-citrate (67Ga citrate)) and specific tracers (e.g., white blood cells radiolabeled with 111Indium-oxine (111In) or 99mTechnetium (99mTc)) showed interesting results for many inflammatory lung diseases. However, 67Ga citrate is unfavorable by a radioprotection point of view while radiolabeled white blood cells scan implies complex laboratory settings and labeling procedures. Radiolabeled antibiotics (e.g., ciprofloxacin) have been recently tested, although they seem to be quite unspecific and cause antibiotic resistance. New radiolabeled agents like antimicrobic peptides, binding to bacterial cell membranes, seem very promising. Thus, the aim of this narrative review is to provide a comprehensive overview about techniques, including PET/MRI, and tracers that can guide the clinicians in the appropriate diagnostic pathway of infectious and inflammatory pulmonary diseases.

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“…With uncertainty of the long‐term effect of Gd in the brain, currently discussed worldwide, it is increasingly desirable to transfer the established information obtained from a contrast‐enhanced MR technique to noncontrast MR methods. However, this transition to MRI without contrast enhancement is still under way, with intensive efforts of investigators by utilizing innovative approaches, including T 1 mapping, self‐gated noncontrast MRI, diffusion‐weighted imaging, and phase‐resolved functional techniques 66–69 . One such promising methodology using normalized T 1 mapping and arterial spin labeling (ASL) has been well validated against multiple inert‐gas elimination techniques and has been employed in CF research studies, but has yet to see full translation to more widespread use 70–72 .…”

Section: Noncontrast Perfusionmentioning

confidence: 99%

Current state of the art MRI for the longitudinal assessment of cystic fibrosis

Woods

Wild

Wielpütz

et al. 2019

Magnetic Resonance Imaging

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Pulmonary MRI can now provide high‐resolution images that are sensitive to early disease and specific to inflammation in cystic fibrosis (CF) lung disease. With specificity and function limited via computed tomography (CT), there are significant advantages to MRI. Many of the modern MRI techniques can be performed throughout life, and can be employed to understand changes over time, in addition to quantification of treatment response. Proton density and T1/T2 contrast images can be obtained within a single breath‐hold, providing depiction of structural abnormalities and active inflammation. Modern radial and/or spiral ultrashort echo‐time (UTE) techniques rival CT in resolution for depiction and quantification of structure, for both airway and parenchymal abnormalities. Contrast perfusion MRI techniques are now utilized routinely to visualize changes in pulmonary and bronchial circulation that routinely occur in CF lung disease, and noncontrast techniques are moving closer to clinical translation. Functional information can be obtained from noncontrast proton images alone, using techniques such as Fourier decomposition. Hyperpolarized‐gas MRI, increasingly using 129Xe, is now becoming more widespread and has been demonstrated to have high sensitivity to early airway obstruction in CF via ventilation MRI. The sensitivity of 129Xe MRI promises future use in personalized medicine, management of early CF lung disease, and in future clinical trials. By combining structural and functional techniques, with or without hyperpolarized gases, regional structure–function relationships can be obtained, giving insight into the pathophysiology of disease and improved clinical management. This article reviews the modern MRI techniques that can routinely be employed for CF lung disease in nearly any large medical center. Level of Evidence: 4 Technical Efficacy Stage: 5 J. Magn. Reson. Imaging 2019.

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Detection and monitoring of lung inflammation in cystic fibrosis during respiratory tract exacerbation using diffusion-weighted magnetic resonance imaging

Cited by 24 publications

References 31 publications

Diffusion-weighted MRI in solitary pulmonary lesions: associations between apparent diffusion coefficient and multiple histopathological parameters

Diffusion-weighted MRI in solitary pulmonary lesions: associations between apparent diffusion coefficient and multiple histopathological parameters

Molecular Imaging of Pulmonary Inflammation and Infection

Current state of the art MRI for the longitudinal assessment of cystic fibrosis

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