Detection and modulation of neurodegenerative processes using graphene-based nanomaterials: Nanoarchitectonics and applications

Tiwari, Priyanka; Tiwari, Sanjay

doi:10.1016/j.cis.2022.102824

Cited by 5 publications

(5 citation statements)

References 235 publications

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“…The neuroprotective ability of fullerenes can be attributed to their small size (less than 1 nm in diameter), and thus increased accessibility within the membrane, as well as antioxidant properties due to their high reactivity towards free radicals, their unique structure, promoting high electrophilicity and strong hydrophobicity, and their ability to cross the blood brain-barrier [50][51][52].…”

Section: Outlook and Conclusionmentioning

confidence: 99%

The Role of Fullerenes in Neurodegenerative Disorders

Wilson,

Ahlawat,

Narayan

2024

JNT

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The use of carbon nanomaterials including fullerenes, carbon nanotubes, carbon nano-onions, carbon dots and carbon quantum dots for environmental applications has increased substantially. These nanoparticles are now used in the development of sensors and switches, in agriculture as smart fertilizers and in the biomedical realm for cancer therapy intervention, as antioxidants, in gene delivery and as theranostics. Here, we review the role of fullerenes as neuroprotectants. Their sp2 hybridized architectures and ability to intervene in the soluble-to-toxic transformation of amyloidogenic trajectories is highlighted here, along with other physico–chemical properties that impact interventional efficacy. Also highlighted are drawbacks that need to be overcome and future prospects.

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Section: Outlook and Conclusionmentioning

confidence: 99%

The Role of Fullerenes in Neurodegenerative Disorders

Wilson,

Ahlawat,

Narayan

2024

JNT

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“…3). 56 Of relevance in this context, Mohammadi et al 50 demonstrated that GQDs at a relatively high concentration of 0.5 g mL −1 can promote aggregation of A53T mutant α-syn by shortening the nucleation step of fibrillation. 57…”

Section: The Potential Of Gbns In the Battle Against Pdmentioning

confidence: 99%

“…103 These opposite effects of GBNs can be explained based on their different physical interaction with cells depending on factors such as synthetic methods, crystallinity, surface functionality, size, and shape. 56 Thus, studies on brain injury or neurotoxicity of GBNs deserve more attention. As outlined in the literature review, several mechanisms such as physical destruction, oxidative stress, DNA damage, inflammatory response, apoptosis, autophagy, and necrosis underly GBNs toxicity.…”

Section: Review Materials Advancesmentioning

confidence: 99%

“…3). 56 Of relevance in this context, Mohammadi et al 50 demonstrated that GQDs at a relatively high concentration of 0.5 g mL À1 can promote aggregation of A53T mutant a-syn by shortening the nucleation step of fibrillation. 57 The most significant research effort on this issue, however, is to examine the effectiveness of GBNs treatment against a-syn toxicity in animal models, and so far, there are only two reports (Table 1).…”

Section: Review Materials Advancesmentioning

confidence: 99%

“…This effect mainly tends to arrest nucleation in the early stages and drive the conversion of preformed insoluble fibrils into soluble peptides that are later pushed across the BBB by efflux pumps, thus preventing neurodegeneration. 56 Moreover, since there is strong evidence of a link between SARS-COV-2 infection and PD, 67 GBNs such as GO or GQDs, beyond being inhibitors of a-syn aggregation due to antiviral activity, offer unique properties to combat PD. 114 The neuroprotection of GBNs also derives from control over protein misfolding attributed to enhanced clearance of aggregated proteins discussed above.…”

Section: Summary and Future Perspectivesmentioning

confidence: 99%

See 2 more Smart Citations

Advances in graphene-based nanoplatforms and their application in Parkinson's disease

Oz,

Kaushik,

Kujawska

2023

Mater. Adv.

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Materials Nanoarchitectonics: Collaboration between Chem, Nano and Mat

Ariga

2023

ChemNanoMat

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Nanoarchitectonics is the methodology for production of functional materials from nano‐units. In nanoarchitectonics, the conversion of molecules (chemistry, Chem), the control of nanostructures (nanotechnology, Nano), and the production of materials (materials science, Mat) are essential elements. In order to explain the contribution of Chem, Nano, and Mat to nanoarchitectonics, this review article is described according to two major sections, Chem & Nano and Nano to Mat. In Chem & Nano section, the integration of chemistry and nanotechnology is overviewed, and the next section, Nano to Mat, illustrates how molecules and nanomaterials are architecturally transformed into functional materials. These include supramolecular polymers and functional metal‐organic frameworks, which have attracted widespread attention, as well as emerging areas such as organic reactions by nanotechnology, chemical synthesis in nanospace, and material creation by dynamic motions at interfaces. It is emphasized that Chem+Nano+Mat is essential for nanoarchitectonics.

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Detection and modulation of neurodegenerative processes using graphene-based nanomaterials: Nanoarchitectonics and applications

Cited by 5 publications

References 235 publications

The Role of Fullerenes in Neurodegenerative Disorders

The Role of Fullerenes in Neurodegenerative Disorders

Advances in graphene-based nanoplatforms and their application in Parkinson's disease

Materials Nanoarchitectonics: Collaboration between Chem, Nano and Mat

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