Detection and maturation of VEP albino asymmetry: an overview and a longitudinal study from birth to 54 weeks

Apkarian, Patricia; Tijssen, Robert

doi:10.1016/s0166-4328(05)80194-9

Cited by 14 publications

(9 citation statements)

References 43 publications

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“…The most striking abnormalities of the response to pattern appearance stimulation in childhood are in latency. The pattern appearance response from the contralateral hemisphere is of shorter latency than normal, whereas that from the ipsilateral hemisphere is of longer latency than normal, giving the well‐described interhemispheric asymmetry (Creel et al ., 1974, 1978, 1981; Carroll et al ., 1980; Apkarian & Tijssen, 1992; Apkarian, 1992; Evrydiki et al ., 1994; Dorey et al ., 2003). In contrast to the flash asymmetry, this latency difference between hemispheres increases with age, apparently reflecting a lengthening in the latency of the ipsilateral pathway.…”

Section: Discussionmentioning

confidence: 99%

Age‐related changes in the dynamics of human albino visual pathways

Neveu

Jeffery²,

Burton

et al. 2003

Eur J of Neuroscience

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A deficiency of melanin in the retinal pigment epithelium, which regulates the development of neural retina, leads to chiasmal misrouting such that the uncrossed pathway (to the ipsilateral hemisphere) is reduced relative to the crossed pathway (to the contralateral hemisphere). This study examines age-related changes in the flash and pattern appearance visual evoked potentials (VEP) of human albinos. Scalp recorded cortical VEPs to flash (FVEP) and pattern appearance stimulation were recorded in 58 albino (8 months to 60 years) and 34 normal subjects (4-55 years). VEPs were analysed by amplitude and latency. The contralateral hemisphere FVEP amplitude decreased with age in albino subjects, as in both hemispheres in normals. However, the ipsilateral hemisphere FVEP amplitude was significantly lower in young albino subjects, initially giving a marked interhemispheric asymmetry, but this normalized with age. Significant interhemispheric FVEP latency asymmetries were not observed. The contralateral pattern appearance VEP latency in albino subjects decreased with age, as in both hemispheres in normals; the ipsilateral latency increased significantly with age. Significant interhemispheric pattern appearance VEP amplitude asymmetries were not observed. These novel and unexpected observations indicate significant age-related changes in the retinocortical pathways of the human albino. These changes have implications for our understanding of development and plasticity of the central visual pathways.

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Section: Discussionmentioning

confidence: 99%

Age‐related changes in the dynamics of human albino visual pathways

Neveu

Jeffery²,

Burton

et al. 2003

Eur J of Neuroscience

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“…10,15 For fVEP, according to Apkarian and Tijssen, 12 latency regions of up to 200 ms are more than sufficient for the assessment of misrouting in neonates and can even be smaller in older subjects. 12 Russell-Eggitt et al 9 concluded that an early fVEP asymmetry occurs at around 80 ms, independent of age, and a greater second asymmetry window occurs in a more variable window between 96-178 ms. Based on these studies, we calculated the chiasm coefficient in a 60-150 ms interval for poVEP and 60-200 ms for fVEP. This should be sufficient to capture all relevant asymmetry, and it copes with the slight delay caused by integration over the previously recorded 60 ms in the calculation of the chiasm coefficient.…”

Section: Apparatus Misrouting Calculation and Statisticsmentioning

confidence: 99%

“…For both standard and hh fVEPs, we calculated the chiasm coefficient in a window of 60-200 ms. 12 Pattern-Onset VEP. We used two different kinds of poVEP stimuli.…”

Section: Apparatus Misrouting Calculation and Statisticsmentioning

confidence: 99%

“…The pattern reversal and hemifield stimulation proved to be unreliable. 2,4,[8][9][10][11][12] Therefore, the International Society for Clinical Electrophisiology of Vision (ISCEV) guide recommends for multichannel VEP recordings to use fVEP in young children and poVEP in children ‡6 years and adults. 13 Earlier studies compared phenotypically evident albinism subjects to controls without ocular pathology, except for idiopathic nystagmus.…”

mentioning

confidence: 99%

“…13 Earlier studies compared phenotypically evident albinism subjects to controls without ocular pathology, except for idiopathic nystagmus. 2,4,[7][8][9][10][11][12]14 The purpose of this study is to evaluate if the currently recommended VEP stimuli are still applicable for a more heterogeneous group of albinism subjects and controls and to investigate if the preferred stimulus may also be visual acuity (VA) dependent instead of only age dependent. Also, we investigated if new techniques, that is monocular handheld Ganzfeld and short-onset acuity sweep, could improve the detection rate of misrouting.…”

mentioning

confidence: 99%

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The Detection Of Misrouting In Albinism: Evaluation of Different VEP Procedures in a Heterogeneous Cohort

Kruijt

Wit

Talsma

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To investigate the optimal procedures for multichannel visually evoked potentials (VEPs) to detect misrouting in albinism subjects. METHODS. Investigations were done in a phenotypically heterogeneous group of 180 albinism subjects and 187 controls with and without ocular pathology. We retrospectively compared standard flash VEP (fVEP), high-frequency fVEP with a handheld device (hh fVEP), patternonset VEP (poVEP), and short-onset acuity sweep VEP. The diagnostic power of these stimuli were estimated by calculating the area under the curve (AUC). Subjects were divided in three age groups (<3, 3-6 [toddler], and ‡6 years). Subjects ‡6 years of age were further divided in two visual acuity groups (0.3 logMAR and >0.3 logMAR). RESULTS. The optimal stimulus was hh fVEP, standard fVEP, and poVEP 60 0 for subjects <3, 3-6, and ‡6 years of age, respectively. In subjects ‡6 years old with poor visual acuity, the area under the curve of fVEP was almost equal to that of poVEP 60 0. CONCLUSIONS. For the optimal detection of misrouting with multichannel VEP recordings, we recommend using a high-frequency hh fVEP in children <3 years of age, standard fVEP in toddlers, and poVEP 60 0 in subjects ‡6 years of age. fVEP can also be used in the oldest age group for subjects with visual acuity of >0.3 logMAR. Remarkably, some albinism subjects showed misrouting on full-field stimulation but normal routing of the central retina, suggesting that not the whole line of decussation is shifted temporally.

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Inborn Errors of Metabolism Affecting the Retina

Olitsky¹

2010

Pediatric Retina

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Detection and maturation of VEP albino asymmetry: an overview and a longitudinal study from birth to 54 weeks

Cited by 14 publications

References 43 publications

Age‐related changes in the dynamics of human albino visual pathways

Age‐related changes in the dynamics of human albino visual pathways

The Detection Of Misrouting In Albinism: Evaluation of Different VEP Procedures in a Heterogeneous Cohort

Inborn Errors of Metabolism Affecting the Retina

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