Detection and isolation of Helicobacter mustelae from stoats in New Zealand

Forester, N.T.; Lumsden, J S; Parton, Kevin A.; Cowan, P. E.; O’Toole, Paul W.

doi:10.1080/00480169.2003.36354

Cited by 6 publications

(4 citation statements)

References 8 publications

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“…H. mustelae is widespread among colonies of laboratory ferrets (180,331,396) and has also been seen in ferrets kept as pets (156). Although examination of adult ferrets from one New Zealand pelt farm failed to find any evidence of infection (290), more recently H. mustelae has been isolated from captive and wild ferrets in New Zealand (131). It seems likely that H. mustelae is a member of the resident flora of the ferret stomach that infects virtually all animals by adulthood, much as is true for human H. pylori infection in most of the world.…”

Section: Helicobacter Mustelaementioning

confidence: 98%

Emergence of DiverseHelicobacterSpecies in the Pathogenesis of Gastric and Enterohepatic Diseases

2001

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Since Helicobacter pylori was first cultivated from human gastric biopsy specimens in 1982, it has become apparent that many related species can often be found colonizing the mucosal surfaces of humans and other animals. These other Helicobacter species can be broadly grouped according to whether they colonize the gastric or enterohepatic niche. Gastric Helicobacter species are widely distributed in mammalian hosts and are often nearly universally prevalent. In many cases they cause an inflammatory response resembling that seen with H. pylori in humans. Although usually not pathogenic in their natural host, these organisms serve as models of human disease. Enterohepatic Helicobacter species are an equally diverse group of organisms that have been identified in the intestinal tract and the liver of humans, other mammals, and birds. In many cases they have been linked with inflammation or malignant transformation in immunocompetent hosts and with more severe clinical disease in immunocompromised humans and animals. The purpose of this review is to describe these other Helicobacter species, characterize their role in the pathogenesis of gastrointestinal and enterohepatic disease, and discuss their implications for our understanding of H. pylori infection in humans

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Section: Helicobacter Mustelaementioning

confidence: 98%

Emergence of DiverseHelicobacterSpecies in the Pathogenesis of Gastric and Enterohepatic Diseases

2001

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“…Whether antigenic variation in the surface ring structures of H. mustelae takes place during the course of an actual infection remains to be demonstrated. It was shown recently that ferrets naturally infected with H. mustelae develop antibody to Hsr (8). Interestingly, phase variation in H. pylori is associated with the blood group-related Lewis antigens, particularly Lewis x and Lewis y, found in the lipopolysaccharide layer of the bacteria (3,27).…”

Section: Discussionmentioning

confidence: 99%

Failure of Surface Ring Mutant Strains of Helicobacter mustelae To Persistently Infect the Ferret Stomach

et al. 2003

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Helicobacter mustelae, the gastric pathogen of ferrets, produces an array of surface ring structures which have not been described for any other member of the genus Helicobacter, including H. pylori. The unique ring structures are composed of a protein named Hsr. To investigate whether the Hsr rings are important for colonization of the ferret stomach, ferrets specific pathogen free for H. mustelae were inoculated with an Hsr-deficient mutant strain or the wild-type H. mustelae strain. Quantitative cultures from antral biopsy specimens obtained at 3, 6, and 9 weeks postinoculation demonstrated no significant difference in the levels of bacteria in the ferrets that received the Hsr-negative strain and the ferrets infected with the parent strain. However, when the ferrets were biopsied at 12 and 15 weeks and necropsied at 18 weeks after infection, the levels of bacteria of the Hsr-negative strain in the stomach antrum were significantly reduced. This decline contrasted the robust antral colonization by the wild-type strain. The Hsr-negative strain did not efficiently colonize the gastric body of the study ferrets. Histological examination at 18 weeks postinoculation revealed minimal gastric inflammation in the animals that received the mutant H. mustelae strain, a finding consistent with its waning infection status, whereas lesions characteristic of helicobacter infection were present in ferrets infected with the wild-type strain. Scant colonization by the Hsr-negative H. mustelae strain at the end of the 18-week study, despite initial successful colonization, indicates an inability of the mutant to persist, perhaps due to a specific host response.

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“…Every ferret with chronic gastritis is infected with H. mustelae, whereas specific pathogen-free (SPF) ferrets not infected with H. mustelae do not have gastritis, gastric ulcers, or detectable IgG antibody to the organism (Fox et al, , 1991a. Helicobacter mustelae has also been isolated from the stomachs of ferrets living in England, Canada, Australia and, most recently, from ferrets in New Zealand (Forester et al, 2000;Tompkins et al, 1988).…”

Section: Helicobacter Mustelaementioning

confidence: 99%

Biology and Diseases of Ferrets

Marini¹,

Otto²,

Erdman³

et al. 2002

Laboratory Animal Medicine

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Detection and isolation of Helicobacter mustelae from stoats in New Zealand

Abstract: Helicobacter mustelae is present in stoats from both the North and South Islands of New Zealand.

Cited by 6 publications

References 8 publications

Emergence of DiverseHelicobacterSpecies in the Pathogenesis of Gastric and Enterohepatic Diseases

Emergence of DiverseHelicobacterSpecies in the Pathogenesis of Gastric and Enterohepatic Diseases

Failure of Surface Ring Mutant Strains of Helicobacter mustelae To Persistently Infect the Ferret Stomach

Biology and Diseases of Ferrets

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