Detection and identification of morphine in urine extracts using thin-layer chromatography and tandem mass spectrometry

An immunochromatographic dipstick as an alternate for monitoring of heroin metabolites in urine samples

“…1,6,7 Till date, many qualitative as well as quantitative techniques have been described for the detection of opiate drugs such as high-pressure liquid chromatography (HPLC), capillary electrophoresis (CE), thinlayer chromatography (TLC), gas chromatography (GC), and mass spectroscopy (MS). [8][9][10][11] However, these techniques are time consuming, require many cleanup steps, and trained personnel, due to which immunosensor based methods have emerged as a better alternative as they have the potential to provide continuous data streams for the rapid and on-site detection of narcotic drugs. 12 Specic binding between antibody and its antigen in immunosensors make them highly sensitive and specic and can thus be developed for the detection of various analytes such as pesticides, narcotic drugs, preeclampsia and cancer etc.…”

Determination of organic impurities in pharmaceutical preparations

“…MS [109,110] and IR [92,111] spectrometers can be also used as the detection systems in TLC. These methods commonly allow the identification of unknown organic impurities by comparing the obtained spectra with library spectra.…”

Nucleic Acids and Their Derivatives

“…Fast atom bombardment coupled with mass spectrometry (FAB/MS) and tandem mass spectrometry (MS/MS) can be done on urine following chromatography on silica gel HPTLC plates (67). Tandem mass spectrometry uses two stages of mass analysis, one to preselect an ion and the second to analyze the fragments induced, for instance, by collision with an inert gas such as argon or helium.…”