Detection and identification of immobilized low-volatility organophosphates by desorption ionization mass spectrometry

Hagan, Nathan; Cornish, Timothy J.; Pilato, Robert S.; Houten, Kelly A. Van; Antoine, Miquel D.; Lippa, T. P.; Becknell, Alan F.; Demirev, Plamen A.

doi:10.1016/j.ijms.2008.04.009

Cited by 26 publications

(12 citation statements)

References 54 publications

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“…Significant ion suppression due to matrix effects was observed in this study. In another application, DESI was coupled to IT-MS and LDI to TOF-MS for the detection of the organophosphate pesticides malathion and dicrotophos after spotting of the sample on a slide (Hagan et al, 2008). Although no attempt was made to determine organophosphate pesticides at residue levels, it was found that DESI was more sensitive than LDI and that neither LDI nor DESI-MS required sample pre-treatment for successful detection and confirmation of the target analytes.…”

Section: Ionization Techniques/interfacesmentioning

confidence: 99%

Current mass spectrometry strategies for the analysis of pesticides and their metabolites in food and water matrices

Botitsi¹,

Garbis

Economou

et al. 2010

Mass Spectrometry Reviews

153

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Analysis of pesticides and their metabolites in food and water matrices continues to be an active research area closely related to food safety and environmental issues. This review discusses the most widely applied mass spectrometric (MS) approaches to pesticide residues analysis over the last few years. The main techniques for sample preparation remain solvent extraction and solid-phase extraction. The QuEChERS (Quick, Easy, Cheap, Effective, Rugged, Safe) approach is being increasingly used for the development of multi-class pesticide residues methods in various sample matrices. MS detectors-triple quadrupole (QqQ), ion-trap (IT), quadrupole linear ion trap (QqLIT), time-of-flight (TOF), and quadrupole time-of-flight (QqTOF)-have been established as powerful analytical tools sharing a primary role in the detection/quantification and/or identification/confirmation of pesticides and their metabolites. Recent developments in analytical instrumentation have enabled coupling of ultra-performance liquid chromatography (UPLC) and fast gas chromatography (GC) with MS detectors, and faster analysis for a greater number of pesticides. The newly developed "ambient-ionization" MS techniques (e.g., desorption electrospray ionization, DESI, and direct analysis in real time, DART) hyphenated with high-resolution MS platforms without liquid chromatography separation, and sometimes with minimum pre-treatment, have shown potential for pesticide residue screening. The recently introduced Orbitrap mass spectrometers can provide high resolving power and mass accuracy, to tackle complex analytical problems involved in pesticide residue analysis.

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Section: Ionization Techniques/interfacesmentioning

confidence: 99%

Current mass spectrometry strategies for the analysis of pesticides and their metabolites in food and water matrices

Botitsi¹,

Garbis

Economou

et al. 2010

Mass Spectrometry Reviews

153

View full text Add to dashboard Cite

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“…DESI‐MS has been used for a variety of direct analyses14 including the analysis of pharmaceutical products,15–26 dyestuffs on thin layer chromatography plates,27 explosives on a variety of surfaces,22, 28–30 polymers,31 alkaloids on plant tissue,32 CWA on solid‐phase microextraction (SPME) fibers,33, 34 hydrolysis products of CWA on Teflon or glass surfaces,35 and pesticides spiked onto immobilized powders or various surfaces (glass, PTFE, Kapton and paper) 36. Dimethyl methylphosphonate (DMMP), a CWA simulant, has been included in many MS method evaluations as it provides an indication of the method's applicability to CWA 10, 22, 24, 29, 30…”

mentioning

confidence: 99%

Desorption electrospray ionization mass spectrometric analysis of organophosphorus chemical warfare agents using ion mobility and tandem mass spectrometry

D’Agostino

Chenier

2010

Rapid Comm Mass Spectrometry

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Desorption electrospray ionization mass spectrometry (DESI-MS) has been applied to the direct analysis of sample media for target chemicals, including chemical warfare agents (CWA), without the need for additional sample handling. During the present study, solid-phase microextraction (SPME) fibers were used to sample the headspace above five organophosphorus CWA, O-isopropyl methylphosphonofluoridate (sarin, GB), O-pinacolyl methylphosphonofluoridate (soman, GD), O-ethyl N,N-dimethyl phosphoramidocyanidate (tabun, GA), O-cyclohexyl methylphosphonofluoridate (cyclohexyl sarin, GF) and O-ethyl S-2-diisopropylaminoethyl methyl phosphonothiolate (VX) spiked into glass headspace sampling vials. Following sampling, the SPME fibers were introduced directly into a modified ESI source, enabling rapid and safe DESI of the toxic compounds. A SYNAPT HDMS instrument was used to acquire time-aligned parallel (TAP) fragmentation data, which provided both ion mobility and MS(n) (n = 2 or 3) data useful for the confirmation of CWA. Unique ion mobility profiles were acquired for each compound and characteristic product ions of the ion mobility separated ions were produced in the Triwave transfer collision region. Up to six full scanning MS(n) spectra, containing the [M + H](+) ion and up to seven diagnostic product ions, were acquired for each CWA during SPME fiber analysis. A rapid screening approach, based on the developed methodology, was applied to several typical forensic media, including Dacron sampling swabs spiked with 5 microg of CWA. Background interference was minimal and the spiked CWA were readily identified within one minute on the basis of the acquired ion mobility and mass spectrometric data.

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“…The Einzel lens was characterized with a 100 and 500 eV ion beam of SF 6 . Variation in the center electrode was 0-750 V. The resulting ion current is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Due to current high-vacuum constraints, companies such as MKS ͑Andover, MA͒, Air Squared ͑Broomfield, CO͒, Pfeiffer ͑Nashua, NH͒, Varian ͑Palo Alto, CA͒, and KNF Neuberger ͑Trenton, NJ͒ have produced portable low-vacuum roughing and high-vacuum turbo pumps, allowing mass spectrometric instruments to become smaller. Groups at Oak Ridge National Laboratory, 1,2 Brigham Young University, 3,4 Johns Hopkins, 5,6 and Purdue University 7, 8 have developed small mass selectors, such as the submillimeter ion trap, small toroidal ion trap, minitime of flight ͑TOF͒, and rectilinear ion trap mass spectrometers. Ion detection has also been made microscale with small channeltron 9 and microchannel plate 10 detectors.…”

Section: Microelectromechanical System Assembled Ion Optics: An Advanmentioning

confidence: 99%

Microelectromechanical system assembled ion optics: An advance to miniaturization and assembly of electron and ion optics

Fox

Saini

Tsui

et al. 2009

Review of Scientific Instruments

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Deep-reactive ion etching of n-doped silicon-on-insulator is utilized to make ion optical components to aid in the miniaturization of mass analyzers. The microelectromechanical system components are bound to aluminum nitride substrates and employed three-dimensional assembly. The assembly methods are tested for breakdown (V(b)), durability, and alignment. Demonstration of ion manipulation is shown with a 1 mm Bradbury-Nielsen gate, 500 mum Einzel lens, 500 mum coaxial ring ion trap, and reflectron optics. Data are presented showing the resolution, attenuation, and performance of each of these devices. We demonstrate advantages and disadvantages of this technology and its applications to mass analysis.

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Detection and identification of immobilized low-volatility organophosphates by desorption ionization mass spectrometry

Cited by 26 publications

References 54 publications

Current mass spectrometry strategies for the analysis of pesticides and their metabolites in food and water matrices

Current mass spectrometry strategies for the analysis of pesticides and their metabolites in food and water matrices

Desorption electrospray ionization mass spectrometric analysis of organophosphorus chemical warfare agents using ion mobility and tandem mass spectrometry

Microelectromechanical system assembled ion optics: An advance to miniaturization and assembly of electron and ion optics

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