Detection and Genotyping of HPV DNA in a Group of Unvaccinated Young Women from Colombia: Baseline Measures Prior to Future Monitoring Program

Puerto, Devi; Reyes, Viviana; Lozano, Cristina Bravo; Buitrago, Lina; García, Diego; Murillo, Raúl; Muñóz, Núbia; Hernández, Gustavo; Sánchez, Laura Estella; Wiesner, Carolina; Cómbita, Alba Lucía

doi:10.1158/1940-6207.capr-17-0439

Cited by 12 publications

(25 citation statements)

References 42 publications

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“…The detection of multiple HPV infections was also common than a single HPV infection. It is important to note that the Roche Linear Array HPV Genotyping Test was also used in a Colombian study [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa

et al. 2021

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As part of the human papillomavirus (HPV) vaccination strategy in South Africa, it is essential to have information on HPV prevalence, and HPV types distribution among the unvaccinated population. Information on the prevalence of HPV and the distribution of HPV types in adolescents and young women in South Africa’s Eastern Cape Province is minimal. Therefore, this study investigates the prevalence, distribution of HPV types, and factors associated with HPV infection amongst unvaccinated female learners. A sample composed of 213 sexually active female learners attending high schools in the Eastern Cape Province of South Africa; median age 18 years, who provided self-collected vaginal specimens. Roche Linear Array HPV genotyping assay that detects 37 HPV genotypes was used to detect HPV infection. HPV infection was detected in 76.06% (162/213) of participants. Of these 14.55% (31/213) were positive for HPV types targeted by the Cervarix® HPV vaccine (HPV-16 and/or 18), 20.66% (44/213) by Gardasil®4 (HPV-6, -11, -16 and/or -18) and 37.09% (79/213) by Gardasil®9 (HPV-6, -11, -16, -18, -31, -33, -45, -52 and/or -58). HPV-35, commonly detected in cervical cancer cases among women of African ancestry, was frequently detected (9.40%). Participants who reported to have ever consumed alcohol had a significantly higher risk of HPV infection (OR: 2.91, 95% CI: 1.38–6.11, p = 0.005). High HPV prevalence was observed among participants. The high prevalence of HPV types targeted by the Gardasil®9 vaccine encourages the introduction of the Gardasil®9 vaccine. Data from this study will inform both vaccination campaigns and monitor the impact on HPV types after vaccination.

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Section: Discussionmentioning

confidence: 99%

High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa

et al. 2021

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“…This will allow countries to vaccinate multiple age cohorts up to 18 years with two doses at introduction, thus saving resources and making the program more cost-effective. In fact, Colombia has extended the target age for HPV vaccination for girls up to 17 years with two doses [15]. Many other countries can follow the same example with a formal recommendation from the WHO, thus achieving a higher impact of HPV vaccination and accelerating progress towards cervical cancer elimination.…”

Section: Discussionmentioning

confidence: 99%

Two-dose recommendation for Human Papillomavirus vaccine can be extended up to 18 years – updated evidence from Indian follow-up cohort study

Basu

Muwonge

Bhatla

et al. 2019

Papillomavirus Research

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Earlier publication from the ongoing multi-centric study of the International Agency for Research on Cancer to evaluate less than three doses of the quadrivalent Human Papillomavirus (HPV) vaccine in India amongst unmarried girls demonstrated non-inferior total antibody titres, neutralizing antibody titres and antibody avidity in 2-dose recipients compared to 3-dose recipients at 15–18 years of age (Bhatla et al., 2018) [7]. The number of participants recruited at 15–18 years of age was 1515 and 1795 in the 3-dose and the 2-dose groups respectively. At a median follow-up of 7 years, incident HPV 16/18 infections were detected in 1.6% women receiving two doses and 0.8% women receiving three doses at 15–18 years. Frequency of incident infection was 7.0% in the age- and site-matched unvaccinated women (N = 1484). No persistent infection from HPV 16 was observed in the 2- or 3-dose recipients and one (0.2%) persistent HPV 18 infection was documented, each in the 3-dose and 2-dose cohorts. Among the unvaccinated women, the frequency of HPV 16/18 persistent infection was 1.7%. The protection offered by two doses of quadrivalent HPV vaccine against incident and persistent infections in recipients at 15–18 years is comparable to that seen in 3-dose recipients at 15–18 years.

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“…To evaluate the effectiveness of the HPV vaccination program, type-specific HPV prevalence was compared between 1451 vaccinated and 951 non-vaccinated women aged 18-25 years old, from a single Colombian city, 5 years after vaccination [34]. Significant reductions were observed in all vaccine types, with a reduction of 74% for HPV 6, 100% for HPV 11, 73% for HPV 16 and 55% for HPV 18.…”

Section: Monitoring Effectiveness Of Hpv Vaccination In Colombiamentioning

confidence: 99%

Prevention and control of HPV infection and HPV-related cancers in Colombia- a meeting report

et al. 2020

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The Human Papillomavirus (HPV) Prevention and Control Board is an independent multidisciplinary board of international experts that disseminates relevant information on HPV to a broad array of stakeholders and provides guidance on strategic, technical and policy issues in the implementation of HPV control programs. In response to drastic drop of vaccine coverage following the adverse event crisis in Carmen del Bolivar, Colombia, the HPV Prevention and Control Board in collaboration with the Colombian National Cancer Institute and Colombian League Against Cancer convened a meeting in Bogota, Columbia (November 2018). The goal of the meeting was to bring together national and international group of experts to report the disease burden, epidemiology and surveillance of HPV and HPV-related cancers, to discuss the successes and especially the challenges of HPV vaccination and screening in Colombia, as well as the lessons learnt from neighbouring countries. The meeting provided a platform to confer various stakeholder's perspectives, including the role of the Colombian healthcare system and to catalyse various parts of the public health community in Colombia into effective action. The conclusion of the meeting included following suggestions to strengthen HPV prevention and control: 1) Reintroducing school-based vaccine programs, 2) Integrating primary and secondary prevention programs, 3) Developing an innovative crisis communication plan targeting healthcare workers, teachers and general population, 4) Building trust through efficient and timely communication, 5) Building strong relationship with media to ensure a stable vaccination campaign support, and 6) Promoting empathy among healthcare professionals towards patients to build trust and communicate effectively.

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Detection and Genotyping of HPV DNA in a Group of Unvaccinated Young Women from Colombia: Baseline Measures Prior to Future Monitoring Program

Cited by 12 publications

References 42 publications

High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa

High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa

Two-dose recommendation for Human Papillomavirus vaccine can be extended up to 18 years – updated evidence from Indian follow-up cohort study

Prevention and control of HPV infection and HPV-related cancers in Colombia- a meeting report

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