Detection and diagnostic value of serum NSE and S100B protein levels in patients with seizures associated with mild gastroenteritis

Chen, Hui; Chen, Yong; Zhong, Jian

doi:10.1097/md.0000000000023439

Cited by 3 publications

(5 citation statements)

References 35 publications

(8 reference statements)

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“…[74][75][76][77][78] NSE is a -y-subunit of enolase, a major component of the neuronal cytosol. 79) Chen et al 22) compared serum S100B and NSE protein levels in 46 patients with CwG versus 35 patients with febrile convulsions. They found that serum NSE levels were significantly higher in the CwG group than in the febrile seizure group; however, S100B levels were not significantly different.…”

Section: Biomarker For Differential Diagnosismentioning

confidence: 99%

“…12,13,18,19) There have also been several recent reports on the diagnosis and treatment of CwG. [20][21][22] Therefore, this review includes recent reports of CwG and covers the epidemiology, clinical manifestations, pathophysiology, biomarkers, and treatment with the aim of promoting the recognition and management of CwG.…”

Section: Introductionmentioning

confidence: 99%

“…After the introduction of rotavirus vaccines, some changes in epidemiology and clinical characteristics occurred in rotavirusassociated CwG (RaCwG) as well as norovirus-associated CwG (NaCwG) [ 12 , 13 , 18 , 19 ]. There have also been several recent reports on the diagnosis and treatment of CwG [ 20 - 22 ]. Therefore, this review includes recent reports of CwG and covers the epidemiology, clinical manifestations, pathophysiology, biomarkers, and treatment with the aim of promoting the recognition and management of CwG.…”

Section: Introductionmentioning

confidence: 99%

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Update on benign convulsions with mild gastroenteritis

Lee

Kwon

2022

Clin Exp Pediatr

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Benign convulsions with mild gastroenteritis (CwG) are characterized by afebrile convulsions associated with viral gastroenteritis in previously healthy infants and children. The main causative pathogens are rotavirus and norovirus. CwG occurs frequently in both East Asian and Western countries. The prevalence of CwG was reportedly not decreased by the introduction of rotavirus vaccines, and the prevalence of norovirus-associated CwG has been increasing annually. Convulsions in CwG are usually clustered, do not last longer than 5 minutes, and are mostly generalized. Laboratory diagnostics, electroencephalography (EEG), and imaging findings are usually normal. There is a probability of mild, transient abnormal findings on EEG or imaging limited to the acute disease phase. Although several reports have suggested that pathogens that affect the central nervous system through direct or indirect mechanisms could be related to the pathophysiology of CwG, its mechanism is not fully understood. Several antiepileptic drugs are effective during convulsions; however, long-term antiepileptic treatment is not required as CwG usually has a good prognosis.

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Section: Biomarker For Differential Diagnosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Update on benign convulsions with mild gastroenteritis

Lee

Kwon

2022

Clin Exp Pediatr

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“…Поряд із S-100 важливим нейромедіатором є нейронспецифічна енолаза (NSE). Даний протеїн є формою гліколітичного ізоферменту енолази і вважається багатофункціональним білком [12,14,22]. Слід зазначити, що експресується NSE не лише у цитоплазмі ней ронів та нейроендокринних клітинах гіпофізу, а й у щитоподібній залозі, легенях, підшлунковій залозі та кишечнику [12,14], це вказує на його роль у багатьох патологічних процесах.…”

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“…Даний протеїн є формою гліколітичного ізоферменту енолази і вважається багатофункціональним білком [12,14,22]. Слід зазначити, що експресується NSE не лише у цитоплазмі ней ронів та нейроендокринних клітинах гіпофізу, а й у щитоподібній залозі, легенях, підшлунковій залозі та кишечнику [12,14], це вказує на його роль у багатьох патологічних процесах. На жаль, роботи, присвячені дослідженням ролі S-100 та NSE у процесах цереброінтестинальної взаємодії, досі поодинокі.…”

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Cerebral intestinal interaction in children with autism spectrum disorder

Stoieva

Bratkova

Titkova

et al. 2022

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Background. Autism spectrum disorders (ASD) in children are associated with features of neuropsychological development, characterized by socio-communicative, emotional, and behavioral problems. The processes of interaction between the central and enteric nervous systems, taking into account the inherent RAS reactions of autonomic maladaptation, endogenous stress, eating behavior determine the pathophysiological mechanisms underlying the comorbid pathology of the digestive system. The study was aimed to analyze the cerebral intestinal interaction signs in children with ASD, taking into account the role of NSE and S-100 neurotransmitters. Materials and methods. Sixty-six children with ASD were examined, out of which 45 children had concomitant functional disorders of the digestive system (FDDS). Clinical manifestations of ASD were assessed by the CARS scale; FDDS was diagnosed based on the Rome IV criteria. Serum levels of NSE neurotransmitters and S-100 protein were measured immunochemically. The patients were examined after obtaining informed consent in compliance with the principles of bioethics. Results. According to the data obtained in children with ASD, the frequency of concomitant FDDS is 68.20 %. In this case, ASD in combination with functional disorders of the biliary tract (FDBT) is observed in 22.7 %, with irritable bowel syndrome (IBS) — in 27.30 %, with syntropic FDDS — in 18.20 % of patients. The study traced the association between severe ASD and concomitant FDDS, in particular ASD with isolated IBS (p = 0.004), ASD with isolated FDBT (p = 0.009), ASD with syntropic functional disorders (p = 0.041). Increased serum concentrations of the NSE and S-100 neurotransmitters have been observed in children with concomitant FDDS. The level of S-100 protein and clinical manifestations of FDDS reveal a correlation, the degree of which increases in the following sequence: IBS (r = 0.34), and syntropic FDDS (r = 0.48). Conclusions. Peculiarities of cerebral intestinal interactions in ASD determine the high frequency of FDDS, in the structure of which IBS dominated. The presence of concomitant pathology impacts the clinical manifestations of ASD, complicating its course to a greater extent in cases of syntropic FDDS. Involvement of enteric glial structures in ASD is accompanied by the NSE and S-100 neurotransmitters level increase on the background of concomitant FDDS. The diagnostic value of S-100 protein in IBS in children with ASD is shown.

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Clinic and diagnosis of encephalopathy of critical conditions in children with infectious diseases

Егорова

Klimkin

Вильниц

et al. 2022

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Purpose: to assess the functional state of the brain in critically ill encephalopathy in children with infectious diseases.Materials and methods: 75 patients aged from 1 month to 17 years 11 months with infectious diseases, who were in the intensive care unit of the clinic, were examined, divided into two groups: the main group and the comparison group. Exclusion criteria: patients with cerebral palsy, organic lesions of the central nervous system, neuroinfections and epilepsy. Conducted daily clinical and neurological examination; study of the level of neurospecific proteins (NSE, protein S100) in blood serum; electroencephalography; study of evoked potentials of various modalities; ultrasound examination of the optic nerves, neuroimaging.Results: All patients had general infectious manifestations, the development of sepsis syndrome, cerebral systemic disorders with impaired consciousness, as well as convulsive syndrome. In the acute period of the disease in the main group, NSE values in 87.5% of children were within the upper limit of normal, S100 protein levels were many times higher than those in the comparison group. In dynamics, all patients showed an increase in the level of NSE, which correlated with persistent neurological symptoms in the form of irritability, weakness, and cognitive decline. In the comparison group, an increase in NSE occurred in 53% of children, an increase in S100 - in 83%. By the time of discharge, 47% of patients had an increase NSE and S100 protein. Visual evoked potentials in 84% of the children of the main group in the acute period, had a decrease the amplitude of the N2-P2 cortical response was revealed without significant dynamics in the future, which was accompanied by pronounced clinical manifestations, which made it possible to substantiate the expediency of dispensary observation of children who underwent a critical condition against the background of severe infectious pathology.Conclusion: in infectious diseases in children that are not accompanied by inflammatory processes in the nervous system, but proceed with the development of a critical condition, there is a neuropsychiatric deficit in the outcomes, which necessitates follow-up follow-up of such patients in the future.

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Detection and diagnostic value of serum NSE and S100B protein levels in patients with seizures associated with mild gastroenteritis

Cited by 3 publications

References 35 publications

Update on benign convulsions with mild gastroenteritis

Update on benign convulsions with mild gastroenteritis

Cerebral intestinal interaction in children with autism spectrum disorder

Clinic and diagnosis of encephalopathy of critical conditions in children with infectious diseases

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