Detection and classification of focal liver lesions in patients with colorectal cancer: Retrospective comparison of diffusion-weighted MR imaging and multi-slice CT

Eiber, Matthias; Fingerle, Alexander A.; Brügel, Melanie; Gaa, Jochen; Rummeny, Ernst J.; Holzapfel, Konstantin

doi:10.1016/j.ejrad.2011.01.072

Cited by 46 publications

(20 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 14 15 16 Moreover, the recent introduction of effective adjuvant chemotherapies and advanced diagnostic images has been widening the criteria of IR-CRLMs, although the definition has been variable in different centers. 19 20 21 22 23 24 25 …”

Section: Discussionmentioning

confidence: 99%

Is neoadjuvant chemotherapy necessary for patients with initially resectable colorectal liver metastases in the era of effective chemotherapy?

Son

Hong

et al. 2011

Korean J Hepatobiliary Pancreat Surg

View full text Add to dashboard Cite

Backgrounds/AimsHepatic resection has only guaranteed long-term survival in patients with colorectal liver metastasis (CRLM) even in the era of effective chemotherapy. The definite role of neoadjuvant chemotherapy (NCT) is to improve outcomes of unresectable CRLMs, but it its role has not been defined for initially resectable CRLMs (IR-CRLMs).MethodsWe reviewed the medical records of 226 patients, who had been diagnosed and treated for IR-CRLM between 2003 and 2008; the patients had the following pathologies: 10% had more than 4 nodules, 11% had tumors larger than 5 cm, and 61% had synchronous CRMLs. Among these patients, 20 patients (Group Y) were treated with NCT, and 206 (Group N) did not receive NCT according to their physician's preference. The median follow-up time was 34.1 months.ResultsThe initial surgical plans were changed after NCT to further resection in 20% and to limited resection in 10% of 20 patients. Complication rates of Groups Y (30%) were indifferent from Group N (23%) (p=0.233), but intraoperative transfusions were more frequent in Group N (15%) than in Group Y (5%) (p=0.006). There was one case of hospital mortality (0.44%). Disease-free survival rates in Groups Y and N were 23% and 39%, respectively, and patient survival rates were 42% and 66% (p>0.05). By multivariate analysis, old age (≥60 years), differentiation of primary tumor (poorly/mucinous), resection margin involvement, and no adjuvant chemotherapy were associated with poor patient survival; the number of CRLMs (≥4) was associated with poor disease-free survival.ConclusionsNCT had neither a positive impact nor a negative impact on survival, even with intraoperative transfusion, as observed on operative outcomes for patients with IR-CRLM. Further study is required to elucidate the role of NCT for treatment of patient with IR-CRLMs.

show abstract

Section: Discussionmentioning

confidence: 99%

Is neoadjuvant chemotherapy necessary for patients with initially resectable colorectal liver metastases in the era of effective chemotherapy?

Son

Hong

et al. 2011

Korean J Hepatobiliary Pancreat Surg

View full text Add to dashboard Cite

show abstract

“…Computed Tomography (CT) is an effective tool to detect focal liver lesions [15,10,20]. The CT scans produce detailed cross-sectional images of the abdomen and thereby form the precise description of FLLs, which involves size, shape, position, boundary deformation, spread situation and etc.…”

Section: Introductionmentioning

confidence: 99%

Three-way decision support for diagnosis on focal liver lesions

Chen

Yue

Fujita

et al. 2017

Knowledge-Based Systems

View full text Add to dashboard Cite

“…Nowadays, diffusion-weighted MR imaging (DWI) is increasingly used for hepatic imaging and has been shown to be a valuable tool in both detection and characterization of focal liver lesions with a sensitivity ranging from 86 to 97% and 60 to 91% for subcentimeter lesions [13][14][15][16]. Most studies have been performed for liver metastases of colorectal cancer.…”

Section: Introductionmentioning

confidence: 99%

Improving preoperative detection of synchronous liver metastases in pancreatic cancer with combined contrast-enhanced and diffusion-weighted MRI

et al. 2019

View full text Add to dashboard Cite

Purpose To explore the value of gadolinium-enhanced MRI combined with diffusion-weighted MRI (Gd-enhanced MRI with DWI) in addition to contrast-enhanced CT (CECT) for detection of synchronous liver metastases for potentially resectable pancreatic cancer. Methods By means of a retrospective cohort study we included patients with potentially resectable pancreatic cancer on CECT, who underwent Gd-enhanced MRI with DWI between January 2012 and December 2016. A single observer evaluated MRI and CT and was blinded to imaging, pathology, and surgery reports. Liver lesions were scored in both modalities, using a 3-point scale: 1-benign, 2-indeterminate, 3-malignant (i.e., metastasis). The primary outcome parameters were the presence of liver metastases on Gd-enhanced MRI with DWI and the sensitivity of Gd-enhanced MRI with DWI for synchronous liver metastases. Results We included 66 patients (42 men, 24 women; median age 65 years, range 36-82 years). In 19 patients, liver metastases were present, which were confirmed by histopathology (n = 12), 18 FDG-PET (n = 6), or surgical inspection (n = 1). Gd-enhanced MRI with DWI showed metastases in 16/19 patients (24%), which resulted in a sensitivity of 84% (95% CI 60-97%). Contrast-enhanced MRI showed 156 and DWI 397 metastases (p = 0.051), and 339 were particularly small (\ 5 mm). Conclusions In this study, Gd-enhanced MRI with DWI detected synchronous liver metastases in 24% of patients with potentially resectable pancreatic cancer on CECT with a sensitivity of 84%. Diffusion-weighted MRI showed a greater number of metastases than any other sequence, particularly small metastases (\ 5 mm).

show abstract

Detection and classification of focal liver lesions in patients with colorectal cancer: Retrospective comparison of diffusion-weighted MR imaging and multi-slice CT

Cited by 46 publications

References 32 publications

Is neoadjuvant chemotherapy necessary for patients with initially resectable colorectal liver metastases in the era of effective chemotherapy?

Is neoadjuvant chemotherapy necessary for patients with initially resectable colorectal liver metastases in the era of effective chemotherapy?

Three-way decision support for diagnosis on focal liver lesions

Improving preoperative detection of synchronous liver metastases in pancreatic cancer with combined contrast-enhanced and diffusion-weighted MRI

Contact Info

Product

Resources

About