Detection and Classification of Calcifications on Digital Breast Tomosynthesis and 2D Digital Mammography: A Comparison

Spangler, Marion Lee; Zuley, Margarita L.; Sumkin, Jules H.; Abrams, Gordan; Ganott, Marie A.; Hakim, Christiane M.; Perrin, Ronald L.; Chough, Denise M.; Shah, Rachit D.; Gur, David

doi:10.2214/ajr.10.4656

Cited by 237 publications

(152 citation statements)

References 13 publications

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“…3DBT had been shown to be effective in patients with a mass, FAD, or distortion. It was also shown in this study that 3DBT is not effective for calcifications cases, consistent to results from other studies (Poplack et al, 2007;Spangler et al, 2011).…”

Section: Discussionsupporting

confidence: 93%

Role of Breast Tomosynthesis in Diagnosis of Breast Cancer for Japanese Women

Takamoto¹,

Tsunoda²,

Kikuchi³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Introduction: Mammography is the most basic modality in breast cancer imaging. However, the overlap of breast tissue depicted on conventional two-dimensional mammography (2DMMG) may create significant obstacles to detecting abnormalities, especially in dense or heterogeneously dense breasts. In three-dimensional digital breast tomosynthesis (3DBT), tomographic images of the breast are reconstructed from multiple projections acquired at different angles. It has reported that this technology allows the generation of 3D data, therefore overcoming the limitations of conventional 2DMMG for Western women. We assessed the detectability of lesions by conventional 2DMMG and 3DBT in diagnosis of breast cancer for Japanese women. Methods: The subjects were 195 breasts of 99 patients (median age of 48 years, range 34~82 years) that had been pathologically diagnosed with breast cancer from December 20, 2010 through March 31, 2011. Both conventional 2DMMG and 3DBT imaging were performed for all patients. Detectability of lesions was assessed based on differences in category class. Results: Of the affected breasts, 77 (75.5%) had lesions assigned to the same categories by 2DMMG and 3DBT. For 24 (23.5%) lesions, the category increased in 3DBT indicating improvement in diagnostic performance compared to 2DMMG. 3DBT improved diagnostic sensitivity for patients with mass, focal asymmetric density (FAD), and architectural distortion. However, 3DBT was not statistically superior in diagnosis of the presence or absence of calcification. Conclusions: In this study, 3DBT was superior in diagnosing lesions in form of mass, FAD, and/or architectural distortion. 3DBT is a novel technique that may provide a breakthrough in solving the difficulties of diagnosis caused by parenchyma overlap for Japanese women.

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Section: Discussionsupporting

confidence: 93%

Role of Breast Tomosynthesis in Diagnosis of Breast Cancer for Japanese Women

Takamoto¹,

Tsunoda²,

Kikuchi³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…[28][29][30] Improved lesion visibility, size and classification compared with standard film or digital mammography have been reported [31][32][33][34][35][36][37][38] and the possibility that DBT could reduce the need for additional mammographic views at least for non-calcified lesions [39][40][41][42] has been suggested. There are mixed reports of the sensitivity of DBT for the detection of microcalcifications 32,[43][44][45][46][47][48][49][50][51] that may be partly as a result of the different techniques used for image reconstruction and the need to combine image slices into thicker slabs for optimal visualisation of microcalcification clusters. These observations suggested that DBT was unlikely to be used as a stand-alone imaging modality if a 2D mammogram was required for optimal microcalcification assessment.…”

Section: Diagnostic Accuracymentioning

confidence: 99%

“…33,44,57 Several studies have shown increased specificity of DBT compared with 2D 16,33,45 and in combination with 2D mammography. 16,20,43,46,58 In a multireader multicentre trial using receiver operating characteristic (ROC) analysis, Rafferty et al 17 reported increased diagnostic accuracy of 2D + DBT compared with 2D alone, particularly in the detection of invasive cancers, and a reduction in the false-positive recall rate and a large retrospective evaluation of screening mammography in 13,158 women 59 reported a significantly lower recall rate with 2D + DBT compared with 2D alone, especially for women aged < 50 years and those with dense breasts.…”

Section: Diagnostic Accuracymentioning

confidence: 99%

The TOMMY trial: a comparison of TOMosynthesis with digital MammographY in the UK NHS Breast Screening Programme – a multicentre retrospective reading study comparing the diagnostic performance of digital breast tomosynthesis and digital mammography with digital mammography alone

Gilbert

Tucker

Gillan

et al. 2015

Health Technology Assessment

154

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The TOMMY trial: a comparison of TOMosynthesis with digital MammographY in the UK NHS Breast Screening Programme -a multicentre retrospective reading study comparing the diagnostic performance of digital breast tomosynthesis and digital mammography with digital mammography alone This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: nihredit@southampton.ac.ukThe full HTA archive is freely available to view online at www.journalslibrary.nihr.ac.uk/hta. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Health Technology Assessment journalReports are published in Health Technology Assessment (HTA) if (1) they have resulted from work for the HTA programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. HTA programmeThe HTA programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care.The journal is indexed in NHS Evidence via its abstracts included in MEDLINE and its Technology Assessment Reports inform National Institute for Health and Care Excellence (NICE) guidance. HTA research is also an important source of evidence for National Screening Committee (NSC) policy decisions.For more information about the HTA programme please visit the website: http://www.nets.nihr.ac.uk/programmes/hta This reportThe research reported in this issue of the journal was funded by the HTA programme as project number 09/22/182. The contractual start date was in December 2010. The draft report began editorial review in February 2014 and was accepted for publication in August 2014. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The HTA editors and publisher have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the draft document. However, they do not accept liability for damages or losses arising from material published in this report. Background: Digital breast tomosynthesis (DBT) is a three-dimensional mammography technique with the potential to improve accuracy by improving differentiation between malignant and non-malignant lesions.

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“…It has been shown that DBT increases the detectability of masses in the breast and reduces recalls when used in combination with 2D-mammography in screening [1]. Some studies have shown that detectability of microcalcifications with DBT is slightly lower than with 2D-mammography, whereas others have claimed the converse is true [2][3]. Therefore, it is still unclear whether the detectability of microcalcification clusters in DBT can be as high as that in 2D-mammography.…”

Section: Introductionmentioning

confidence: 99%

Detection of microcalcification clusters by 2D-mammography and narrow and wide angle digital breast tomosynthesis

et al. 2016

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The aim of this study was to compare the detection of microcalcification clusters by human observers in breast images using 2D-mammography and narrow (15°/15 projections) and wide (50°/25 projections) angle digital breast tomosynthesis (DBT). Simulated microcalcification clusters with a range of microcalcification diameters (125 μm-275 μm) were inserted into 6 cm thick simulated compressed breasts. Breast images were produced with and without inserted microcalcification clusters using a set of image modelling tools, which were developed to represent clinical imaging by mammography and tomosynthesis. Commercially available software was used for image processing and image reconstruction. The images were then used in a series of 4-alternative forced choice (4AFC) human observer experiments conducted for signal detection with the microcalcification clusters as targets. The minimum detectable calcification diameter was found for each imaging modality: (i) 2D-mammography: 164±5 μm (ii) narrow angle DBT: 210±5 μm, (iii) wide angle DBT: 255±4 μm. A statistically significant difference was found between the minimum detectable calcification diameters that can be detected by the three imaging modalities. Furthermore, it was found that there was not a statistically significant difference between the results of the five observers that participated in this study. In conclusion, this study presents a method that quantifies the threshold diameter required for microcalcification detection, using high resolution, realistic images with observers, for the comparison of DBT geometries with 2D-mammography. 2D-mammography can visualise smaller detail diameter than both DBT imaging modalities and narrow-angle DBT can visualise a smaller detail diameter than wide-angle DBT.

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Detection and Classification of Calcifications on Digital Breast Tomosynthesis and 2D Digital Mammography: A Comparison

Cited by 237 publications

References 13 publications

Role of Breast Tomosynthesis in Diagnosis of Breast Cancer for Japanese Women

Role of Breast Tomosynthesis in Diagnosis of Breast Cancer for Japanese Women

The TOMMY trial: a comparison of TOMosynthesis with digital MammographY in the UK NHS Breast Screening Programme – a multicentre retrospective reading study comparing the diagnostic performance of digital breast tomosynthesis and digital mammography with digital mammography alone

Detection of microcalcification clusters by 2D-mammography and narrow and wide angle digital breast tomosynthesis

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