Detection and Characterization of the Evolution of Cerebral Abscesses with Diffusion-Weighted Magnetic Resonance Imaging. Two Case Reports.

Mikami, Takeshi; Saito, Koji; Kato, Takuya; Irie, Shinsuke; Yoshikawa, Junpei; Kondô, Shirô

doi:10.2176/nmc.42.86

Cited by 7 publications

(2 citation statements)

References 6 publications

(6 reference statements)

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“…To the best of our knowledge, this is the first study showing the ICAM-1 and LFA-1 expression and its correlation with DTI metrics (FA, CL and CS) in the human BA wall, although the ICAM-1 and LFA-1 expression from the abscess wall has been demonstrated in the experimental brain abscess model (3,4). It is evident from histology, that the BA wall is composed of a combination of concentric layers of collagen fibres intermixed with the neutrophils and macrophages (23) while the cavity contains inflammatory cells, necrotic debris, proteins, and amino acids (28). In this study, FA positively correlated with the percentage area of ICAM-1 and LFA-1 expression in the BA wall as well as NMs quantified from aspirated pus.…”

Section: Discussionmentioning

confidence: 99%

Correlation of DTI metrics in the wall and cavity of brain abscess with histology and immunohistochemistry

et al. 2010

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Diffusion tensor imaging (DTI) was performed in eight patients with brain abscess (BA). The aim of this study was to see the difference in the relationship between intercellular cell adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1) expression and DTI metrics measured in vivo in the wall and cavity of BA and its possible explanation vis-à-vis histology and immunohistochemistry. Neuroinflammatory molecules (NMs) were quantified from BA cavity aspirate of the patients and quantitative immunohistochemical analysis was performed for ICAM-1 and LFA-1 in the BA wall, showing maximal positive staining and correlated with DTI metrics. The fractional anisotropy (FA) significantly increased while mean diffusivity and spherical anisotropy significantly decreased in the BA wall compared to the BA cavity. In the BA wall, FA and linear anisotropy (CL) showed a significant positive correlation with ICAM-1 and LFA-1 expression whereas FA and planar anisotropy positively correlated with NMs quantified from aspirated pus respectively. Higher FA values in the BA wall compared to BA cavity, even when ICAM-1 and LFA-1 were expressed only in the macrophages and not in the collagen fibers, suggests that a combination of both concentric layers of collagen fibers as well as neutrophils and macrophages provide structural orientation and are responsible for increased FA. In the BA wall, increased CL was found compared to the cavity, indicating the presence of concentrically laid collagen fibers responsible for the diffusion of water molecules in the direction parallel to the collagen fibers. We conclude that in the BA, different mechanisms are operative for the changes in the DTI metrics in the wall and cavity; these conclusions are validated by histology and immunohistochemistry.

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Section: Discussionmentioning

confidence: 99%

Correlation of DTI metrics in the wall and cavity of brain abscess with histology and immunohistochemistry

et al. 2010

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“…4,8) MR imaging, particularly diffusion-weighted imaging, is efficacious for differentiating brain abscesses from metastatic brain tumors. 1,7) Although markedly decreased water diffusion is not absolutely specific for brain abscess, 9) it is still a reliable marker for differentiating brain abscesses from metastatic brain tumors. 1,7) Biopsy is the definitive method for establishing the histological diagnosis of a brain tumor and for identifying the microorganisms responsible in brain abscess, but carries substantial perioperative risks in patients with debilitating medical conditions.…”

Section: Discussionmentioning

confidence: 99%

Ring-enhanced Mass in the Brain of a Woman With Systemic Lupus Erythematosus and Elevated Serum CA19-9 Level: Brain Abscess or Metastatic Tumor? Case Report.

Inamasu

Nakamura

Saito

et al. 2003

Neurol. Med. Chir.(Tokyo)

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A 70-year-old woman with systemic lupus erythematosus presented with a brain abscess manifesting as progressive monoparesis of the right lower extremity over 4 days. She had had no episodes of fever, and did not complain of headache or exhibit any signs of meningeal irritability. Computed tomography of the brain showed a round, low-density mass with strong ring enhancement in the left frontal lobe. Laboratory examination found a moderately elevated serum level of CA19-9, a marker of some digestive organ cancers. Together with the absence of febrile episodes, headache, and a rise in leukocyte count, the initial suspicion was metastatic brain tumor rather than brain abscess. However, diffusion-weighted magnetic resonance imaging depicted the mass as a very hyperintense area. The neuroimaging diagnosis was brain abscess. After conservative treatment with intravenous antibiotics for 6 weeks, the brain abscess completely resolved, and the patient was discharged without neurological deficits.

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Der Hirnabszess in der Diffusionswichtung und Unterschiede zum zystischen Hirntumor

Tomczak¹,

Wunderlich

Görich³

et al. 2003

Der Radiologe

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Detection and Characterization of the Evolution of Cerebral Abscesses with Diffusion-Weighted Magnetic Resonance Imaging. Two Case Reports.

Cited by 7 publications

References 6 publications

Correlation of DTI metrics in the wall and cavity of brain abscess with histology and immunohistochemistry

Correlation of DTI metrics in the wall and cavity of brain abscess with histology and immunohistochemistry

Ring-enhanced Mass in the Brain of a Woman With Systemic Lupus Erythematosus and Elevated Serum CA19-9 Level: Brain Abscess or Metastatic Tumor? Case Report.

Der Hirnabszess in der Diffusionswichtung und Unterschiede zum zystischen Hirntumor

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