Detection and characterization of extended-spectrum  -lactamases in Salmonella enterica strains of healthy food animals in Spain

Riaño, I.; Moreno, Miguel A.; Teshager, Tirushet; Sáenz, Yolanda; Domı́nguez, Lucas; Torres, Carmén

doi:10.1093/jac/dkl337

Cited by 76 publications

(63 citation statements)

References 10 publications

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“…In Gram-negative bacteria, the qac genes are often linked with plasmid-mediated class 1 integrons which harbour a variety of antibiotic resistance genes (Zhao et al 2012). In Enterobacteriaceae, the qac genes have been most frequently found in combination with genes coding for resistance to aminoglycosides, chloramphenicol, sulphonamides, trimethoprim and β-lactams (Poirel et al 2000;Riano et al 2006;Espedido et al 2008;Zhao et al 2012). Similar findings were also reported in Pseudomonas aeruginosa (Jeong et al 2009;Colinon et al 2010).…”

Section: The Qac Genes and Resistance To Antibioticsmentioning

confidence: 62%

Genetic basis of resistance to quaternary ammonium compounds - the qac genes and their role: a review

Jaglič¹,

Cervinkova²

2012

Vet. Med.

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ABSTRACT:Although the qac genes are named after one of their main substrates (i.e., quaternary ammonium compounds), these genes also code for resistance to a broad spectrum of other cationic compounds such as intercalating dyes, diamidines and biguanides. The various Qac proteins are involved in relatively low specific effluxbased multidrug pumps and belong to a family of small multidrug resistance proteins. Even though the practical significance of qac-mediated resistance lies mainly in resistance to antiseptics, contradictory findings on this issue are still reported. Therefore, the aim of this review is to summarise the current knowledge on qac-mediated resistance with special emphasis on resistance to antiseptics and its relevance for practice.

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Section: The Qac Genes and Resistance To Antibioticsmentioning

confidence: 62%

Genetic basis of resistance to quaternary ammonium compounds - the qac genes and their role: a review

Jaglič¹,

Cervinkova²

2012

Vet. Med.

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“…(Cloeckaert et al, 2007) Infantis bla Poultry, Swine Yes France, Belgium, Japan (Cloeckaert et al, 2007;Dahshan et al, 2010;Yang et al, 2010) Virchow bla CTX-M-2 , bla CTX-M-9 Poultry Yes Spain, France (Bertrand et al, 2006;Riano et al, 2009;Riano et al, 2006;Weill et al, 2004). Westhampton/ Senftenberg bla Cockles No French supermarkets (Doublet et al, 2009) Heidelberg bla CMY-2 Imported live animals, meat consumption, unpasteurized dairy products Yes EU, USA Folster et al, 2009 (Carattoli, 2009;Golebiewski et al, 2007) IncHI2…”

Section: Plasmidsmentioning

confidence: 99%

“…The ESBL-producers represented only 0.09% of the total number of isolates tested ). In another study in Spain among isolates obtained through the Spanish Veterinary-Antimicrobial-Resistance-Surveillance Network (VAV), 4 of 556 (0.7%) Salmonella organisms obtained from faecal samples of healthy food animals (pigs and poultry) at the slaughterhouse level were ESBL producers, representing 0.2% in the case of pigs and 2.5% of all isolates in the case of poultry (Riano et al, 2006). ESBL-producing Salmonella prevalences of 0.5-0.6% were detected in Italy, Korea and Japan Hur et al, 2010;Matsumoto et al, 2007).…”

Section: Prevalence Of Esbl-producing E Coli and Salmonella In Food-mentioning

confidence: 99%

“…CTX-M-15, the ESBL considered to have spread in a pandemic fashion in humans, was only detected incidentally in food-producing animals or food and in only in a few countries in E. coli (isolated in France from diseased cattle, in Belgium from healthy poultry, and in UK in broiler chickens and turkey) and in Salmonella isolates (Germany, one S. Typhimurium from horse origin) (Madec et al, 2008;Randall et al, 2011;Rodriguez et al, 2009;Smet et al, 2008). ESBLs of the SHV class were frequently detected throughout the EU, especially SHV-12 and SHV-2 Bortolaia et al, 2010b;Boyle et al, 2010;Brinas et al, 2003a;Brinas et al, 2003b;Chiaretto et al, 2008;Cortes et al, 2010;Costa et al, 2009;Dierikx et al, 2010a;Doi et al, 2009;Escudero et al, 2010;Goncalves et al, 2010;Hasman et al, 2005;Hopkins et al, 2006;Kolar et al, 2010;Machado et al, 2008;Madec et al, 2008;Morris et al, 2009;Riano et al, 2006). In relation to the ESBLs of the TEM class, the most frequently detected throughout the EU was TEM-52 Brinas et al, 2005;Carneiro et al, 2010;Cloeckaert et al, 2007;Costa et al, 2009;Dierikx et al, 2010a;Jensen et al, 2006;Machado et al, 2008;Morris et al, 2009;Randall et al, 2011;Rodriguez et al, 2009;Smet et al, 2008).…”

Section: Esbl-subtypes Detected In E Coli and Salmonella From Food-pmentioning

confidence: 99%

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Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

2011

EFSA Journal

240

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The potential contribution of food-producing animals or foods to public health risks by ESBL and/or AmpCproducing bacteria is related to specific plasmid-mediated ESBL and/or AmpC genes encoded by a number of organisms. The predominant ESBL families encountered are CTX-M, TEM, and SHV; the predominant AmpCfamily is CMY. The most common genes associated with this resistance in animals are bla CTX-M-1 (the most commonly identified ESBL), and bla CTX-M-14 , followed by bla and bla Among the genes encoding AmpC-type β-lactamases, bla CMY-2 is the most common.The bacterial species most commonly identified with these genes are Escherichia coli and non-typhoidal Salmonella. ESBL/AmpC transmission is mainly driven by integrons, insertion sequences, transposons and plasmids, some of which are homologous in isolates from both food-production animals and humans. Cefotaxime is used as the drug of choice for optimum detection of bla ESBL and/or bla AmpC genes. The preferred method for isolation of ESBL-and/or AmpC-producers is screening on selective agar preceded by selective enrichment in a broth.The establishment of risk factors for occurrence of ESBL/AmpC-producing bacteria is particularly complicated by the data unavailability or lack of its accuracy. The use of antimicrobials is a risk factor for the selection and spread of resistant clones, resistance genes and plasmids. Since most ESBL-and AmpC-producing strains carry additional resistances to other commonly-used veterinary drugs, generic antimicrobial use is a risk factor for ESBL/AmpC and it is not restricted specifically to the use of cephalosporins. An additional risk factor is extensive trade of animals in EU MS. There are no data on the comparative efficiency of individual control options in reducing public health risks caused by ESBL and/or AmpC-producing bacteria related to food-producing animals. Prioritisation is complex, but it is considered that a highly effective control option would be to stop all uses of cephalosporins/systemically active 3 rd /4 th generation cephalosporins, or to restrict their use (use only allowed under specific circumstances). As co-resistance is an important issue, it is also of high priority to decrease the total antimicrobial use in animal production in the EU. KEY WORDSResistance, ESBLs, AmpC, occurrence, transmission, control options, public health microbiology. SUMMARYFollowing a request from the European Commission, the Panel on Biological Hazards (BIOHAZ) was asked to deliver a Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum beta (β)-lactamases (ESBL) and/or AmpC β-lactamases (AmpC) in food and foodproducing animals. In particular, the Panel was asked: (i) to propose a definition of the ESBL-and/or AmpC-producing bacterial strains and genes relevant for public health and linked to food-producing animals or food borne transmission; (ii) to review the information on the epidemiology of acquired resistance to broad spectrum cephalosporins including the genes coding for ...

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“…Other ESBLs have been found to be more widely distributed. So far, TEM-52-and SHV-12 producing Enterobacteriaceae, isolated especially from poultry, have only been described on the European continent (Briñas et al, 2003;Chiaretto et al, 2008;Cloeckaert et al, 2007;Costa et al, 2009;Hasman et al, 2005;Machado et al, 2008;Smet et al, 2008;Riaño et al, 2006). ESBLs such as CTX-M-1, CTX-M-2 and CTX-M-14 have been found in many European countries, being associated with E. coli mainly from poultry (Briñas et al, 2003;Costa et al, 2009;Girlich et al, 2007;Jouini et al, 2007;Kojima et al, 2005;Machado et al, 2008;Shiraki et al, 2004;Smet et al, 2008).…”

Section: Epidemiology Of Broad-spectrum β-Lactamases Among Enterobactmentioning

confidence: 99%

Transmission of Antibiotic Resistant Enterobacteriaceae between Animals and Humans Gastrointestinal Tract with the Evidence of in vivo Plasmid Transfer

Mahmood¹,

Bal

2014

KSÜ Doğ. Bil. Derg

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Abstract:Recently, the main point of discussion is being undertaken whether the resistance of bacteria and plasmids could have been transmitted to humans from animals. Using antimicrobials in livestock production was previously shown to be followed by the occurrence of the resistant bacteria in the treated animals as well as in humans (caretakers, their family members etc.). Evidences exist that the transmission of resistance might have taken place from animals to humans. Many of these evidences were not direct and were based on the similarities between the resistance profiles of bacteria (among others indicatory E. coli) isolated from animals (poultry, pigs, cattle) and from humans having contact with these animals (farm workers, animal caretakers, their family members). Direct evidences have been based on the molecular methods allowing the detection of either clonally related, resistant zoonotic bacteria in humans and animals or related to resistance of plasmids isolated from humans and animals.

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Detection and characterization of extended-spectrum -lactamases in Salmonella enterica strains of healthy food animals in Spain

Abstract: The emergence of ESBL-producing S. enterica isolates among food animals is described for the first time in Spain, with those of the CTX-M group being the predominant ESBLs detected.

Cited by 76 publications

References 10 publications

Genetic basis of resistance to quaternary ammonium compounds - the qac genes and their role: a review

Genetic basis of resistance to quaternary ammonium compounds - the qac genes and their role: a review

Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

Transmission of Antibiotic Resistant Enterobacteriaceae between Animals and Humans Gastrointestinal Tract with the Evidence of in vivo Plasmid Transfer

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