Detection and characterisation of biopsy tissue using quantitative optical coherence elastography (OCE) in men with suspected prostate cancer

Li, Chunhui; Guan, Guangying; Ling, Yuting; Hsu, Ying Ting; Song, Shaozhen; Huang, Jeffrey T.‐J.; Lang, Stephen; Huang, Zhihong; Nabi, Ghulam

doi:10.1016/j.canlet.2014.11.021

Cited by 64 publications

(52 citation statements)

References 46 publications

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“…OCME could also be used to assess axillary lymph node involvement in breast cancer metastasis, and initial results have been reported (24). Beyond breast cancer, a recent article has proposed the use of a closely related optical elastography technique in prostate cancer (49).…”

Section: Discussionmentioning

confidence: 99%

Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue

et al. 2015

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An accurate intraoperative identification of malignant tissue is a challenge in the surgical management of breast cancer. Imaging techniques that help address this challenge could contribute to more complete and accurate tumor excision, and thereby help reduce the current high reexcision rates without resorting to the removal of excess healthy tissue. Optical coherence microelastography (OCME) is a three-dimensional, high-resolution imaging technique that is sensitive to microscale variations of the mechanical properties of tissue. As the tumor modifies the mechanical properties of breast tissue, OCME has the potential to identify, on the microscale, involved regions of fresh, unstained tissue. OCME is based on the use of optical coherence tomography (OCT) to measure tissue deformation in response to applied mechanical compression. In this feasibility study on 58 ex vivo samples from patients undergoing mastectomy or wide local excision, we demonstrate the performance of OCME as a means to visualize tissue microarchitecture in benign and malignant human breast tissues. Through a comparison with corresponding histology and OCT images, OCME is shown to enable ready visualization of features such as ducts, lobules, microcysts, blood vessels, and arterioles and to identify invasive tumor through distinctive patterns in OCME images, often with enhanced contrast compared with OCT. These results lay the foundation for future intraoperative studies. Cancer Res; 75(16); 3236–45. ©2015 AACR.

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Section: Discussionmentioning

confidence: 99%

Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue

et al. 2015

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“…3,4 For example, previous studies demonstrate the potential of OCE in assessing mechanical properties of di®erent tissues such as cornea, 5,6 skin, 7 breast, 8 and liver. 9 In particular, a subset of dynamic OCE techniques uses short-duration pulses produced by a selected excitation source in order to produce mechanical wave propagation in the tissue being studied. 10 Excitation sources include acoustic radiation force (ARF), air-pu® excitation, laser-based thermal expansion, and needles connected to piezoelectric vibrators, to name just a few.…”

Section: Introductionmentioning

confidence: 99%

An approach to viscoelastic characterization of dispersive media by inversion of a general wave propagation model

Zvietcovich

Rolland

Parker

2017

J. Innov. Opt. Health Sci.

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In the characterization of elastic properties of tissue using dynamic optical coherence elastography, shear/surface waves are propagated and tracked in order to estimate speed and Young's modulus. However, for dispersive tissues, the displacement pulse is highly damped and distorted during propagation, diminishing the e®ectiveness of peak tracking approaches, and leading to biased estimates of wave speed. Further, plane wave propagation is sometimes assumed, which contributes to estimation errors. Therefore, we invert a wave propagation model that incorporates propagation, decay, and distortion of pulses in a dispersive media in order to accurately estimate its elastic and viscous components. The model uses a general¯rst-order approximation of dispersion, avoiding the use of any particular rheological model of tissue. Experiments are conducted in elastic and viscoelastic tissue-mimicking phantoms by producing a Gaussian push using acoustic radiation force excitation and measuring the wave propagation using a Fourier domain optical coherence tomography system. Results con¯rmed the e®ectiveness of the inversion method in estimating viscoelastic parameters in both the viscoelastic and elastic phantoms when compared to mechanical measurements. Finally, the viscoelastic characterization of a fresh porcine cornea was conducted. Preliminary results validate this approach when compared to other methods.

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“…Then, by measuring resultant amplitude of tissue oscillations, its Young modulus E can be evaluated. 15 Such an approach may be limited in its application to the use of excised samples.…”

Section: Introductionmentioning

confidence: 99%

Practical obstacles and their mitigation strategies in compressional optical coherence elastography of biological tissues

Zaitsev

Matveyev

Matveev

et al. 2017

J. Innov. Opt. Health Sci.

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In this paper, we point out some practical obstacles arising in realization of compressional optical coherence elastography (OCE) that have not attracted su±cient attention previously. Speci¯-cally, we discuss (i) complications in quanti¯cation of the Young modulus of tissues related to partial adhesion between the OCE probe and soft intervening reference layer sensor, (ii) distorting in°uence of tissue surface curvature/corrugation on the subsurface strain distribution mapping, (iii) ways of signal-to-noise ratio (SNR) enhancement in OCE strain mapping when periodic averaging is not realized, and (iv) potentially signi¯cant in°uence of tissue elastic nonlinearity on quanti¯cation of its sti®ness. Potential practical approaches to mitigate the e®ects of these complications are also described.

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Detection and characterisation of biopsy tissue using quantitative optical coherence elastography (OCE) in men with suspected prostate cancer

Cited by 64 publications

References 46 publications

Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue

Investigation of Optical Coherence Microelastography as a Method to Visualize Cancers in Human Breast Tissue

An approach to viscoelastic characterization of dispersive media by inversion of a general wave propagation model

Practical obstacles and their mitigation strategies in compressional optical coherence elastography of biological tissues

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