Detection and assay of secondary metabolites of Penicillium vermiculatum DANG

Occurence and Bioactivities of Funicone-Related Compounds

“…This opinion is shared for the formation of deoxyfunicone [ 8 ] and rapicone [ 13 ], in the latter case by considering analogies with other fungal heptaketides. Actually, the presence in the culture filtrates of different strains of T. flavus of other polyketides possibly sharing part of a common biosynthetic pathway, such as vermiculin, vermiculinic acid and compound NG-012 [ 10 , 23 ], corroborates this assumption. However, the finding of 2-methyl-4-hydroxybenzoic acid ( Figure 2 ), particularly abundant in the mycelial cake developed in liquid cultures of P. pinophilum , has stimulated a hypothesis that 3- O -methylfunicone could rather be directly assembled by two molecules of such compound undergoing oxidation [ 24 ].…”

“…Therefore, following the consolidated approach established for taxonomy of the terverticillate Penicillia (subgenus Penicillium ) [ 46 ], the increasing amount of data gathered within this context is susceptible to be considered for chemotaxonomic purposes, particularly in view of attaining to a more accomplished characterization of a number of biverticillate species whose taxonomic status is uncertain [ 4 , 44 , 45 ]. In this regard, methods allowing a rapid analysis of fungal extracts, particularly those based on HPLC [ 11 , 23 , 44 ], are likely to provide a substantial contribution for a more considerable detection of these compounds.…”