Detection and a possible link between parvovirus B19 and thyroid cancer

Etemadi, Ashkan; Mostafaei, Shayan; Yari, Kheirollah; Ghasemi, Amir; Chenar, Hamzeh Minaei; Moghoofei, Mohsen

doi:10.1177/1010428317703634

Cited by 30 publications

(30 citation statements)

References 22 publications

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“…Inflammation could be considered as a double-edged sword; in the initial steps it is crucial for provoking anti-tumor responses by the immune system and after that, it favors tumor development by triggering angiogenesis [23]. Recent investigations indicated that the inflammation is the major hallmark for tumor progression [60, 62]. Among the inflammatory cytokines, IL-1, TGF-β, and IL-6 are responsible for cancer cells proliferation and invasion through activation of NF-κB.…”

Section: Discussionmentioning

confidence: 99%

Human papilloma virus and breast cancer: the role of inflammation and viral expressed proteins

et al. 2019

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BackgroundBreast cancer is currently the most common neoplasm diagnosed in women globally. There is a growing body of evidence to suggest that human papillomavirus (HPV) infection may play a key role in invasiveness of breast cancer. The aim of this study was to determine the presence of HPV in patients with breast cancer and its possible association with cancer progression.MethodsBreast specimens were collected from 72 patients with breast cancer and 31 healthy controls. The presence of HPV was investigated by polymerase chain reaction (PCR) and genotyping was performed for positive cases. We also evaluated the viral factors such as E6, E2, and E7 in HPV positive cases. Enzyme-linked immunosorbent assay (ELISA (and Real-time PCR techniques were used to measure the expression level of anti-carcinogenic genes, such as p53, retinoblastoma (RB), breast and ovarian cancer susceptibility gene (BRCA1, BRCA2) and inflammatory cytokines, including tumor necrosis factor α (TNF-α), transforming growth factor β (TGF-β), nuclear factor-kB (NF-kB), and different interleukins [ILs] (IL-1,IL6, and IL-17).ResultsThe HPV DNA was detected in 48.6% of breast cancer samples, whereas only 16.1% of controls were positive for HPV. We observed statistically significant differences between breast cancer patients and HPV presence (P = 0.003). HPV type 18 was the most prevalent virus genotype in patients. The expression of P53, RB, BRCA1, and BRCA2 were decreased in patients with HPV-positive breast cancer as compared to HPV-negative breast cancer and healthy controls. (All P-values were less than 0.05). The presence of the HPV was associated with increased inflammatory cytokines (IL-1, IL-6, IL-17, TGF-β, TNF-α, and NF-kB) and tumor progression.ConclusionThe present study demonstrated that HPV infection may implicate in the development of some types of breast cancer.

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Section: Discussionmentioning

confidence: 99%

Human papilloma virus and breast cancer: the role of inflammation and viral expressed proteins

et al. 2019

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“…The pathogenesis of lung cancer is a complex multifactor process with both genetic and environmental factors playing a major role [ 3 ]. Infectious agents are emerging as key drivers in the development of cancer [ 4 – 7 ]. Previously, numerous infectious agents have been shown to be involved in a myriad of lung diseases including cancer, Idiopathic Pulmonary Fibrosis (IPF) and Chronic Obstructive Pulmonary Disease (COPD) [ 8 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

The association between HPV gene expression, inflammatory agents and cellular genes involved in EMT in lung cancer tissue

et al. 2020

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Background Lung cancer is a leading cause of cancer morbidity and mortality worldwide. Several studies have suggested that Human papillomavirus (HPV) infection is an important risk factor in the development of lung cancer. In this study, we aim to address the role of HPV in the development of lung cancer mechanistically by examining the induction of inflammation and epithelial-mesenchymal transition (EMT) by this virus. Methods In this case-control study, tissue samples were collected from 102 cases with lung cancer and 48 controls. We examined the presence of HPV DNA and also the viral genotype in positive samples. We also examined the expression of viral genes (E2, E6 and E7), anti-carcinogenic genes (p53, retinoblastoma (RB)), and inflammatory cytokines in HPV positive cases. Results HPV DNA was detected in 52.9% (54/102) of the case samples and in 25% (12/48) of controls. A significant association was observed between a HPV positive status and lung cancer (OR = 3.37, 95% C.I = 1.58–7.22, P = 0.001). The most prevalent virus genotype in the patients was type 16 (38.8%). The expression of p53 and RB were decreased while and inflammatory cytokines were increased in HPV-positive lung cancer and HPV-positive control tissues compared to HPV-negative lung cancer and HPV-negative control tissues. Also, the expression level of E-cad and PTPN-13 genes were decreased in HPV- positive samples while the expression level of SLUG, TWIST and N-cad was increased in HPV-positive samples compared to negative samples. Conclusion Our study suggests that HPV infection drives the induction of inflammation and EMT which may promote in the development of lung cancer.

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“…The main site of B19V replication is inside the erythroid progenitor cells, bone marrow (7). Although it leaves no clinical impact on healthy individuals, it could cause anemia in immunocompromised hosts (3,8). In the course of B19V infection, a brief period of viremia occurs which is mostly self-limited.…”

Section: Introductionmentioning

confidence: 99%

Association between Parvovirus B19 and anemia in HIV-infected patients

Nouri

Kamakifar

Khodabandehlou

et al. 2019

Med. J. Islam. Republ. Iran

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Parvovirus B19 infection is involved in several clinical manifestations such as erythema infectiosum, chronic arthritis, hydrops fetalis, and transient aplastic crisis in patients with sickle cell anemia and pure red cell aplasia in immunocompromised hosts. This virus can lead to self-limited anemia in healthy individuals; however, it can develop into chronic anemia in immunocompromised cases. →What this article adds: The present study evaluated the association between anemia and B19V in HIV patients. Also, the threat of B19V is limited in the HIV patients receiving ART, whereas persistent B19 viremia in the untreated patients may lead to anemia.

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Detection and a possible link between parvovirus B19 and thyroid cancer

Cited by 30 publications

References 22 publications

Human papilloma virus and breast cancer: the role of inflammation and viral expressed proteins

Human papilloma virus and breast cancer: the role of inflammation and viral expressed proteins

The association between HPV gene expression, inflammatory agents and cellular genes involved in EMT in lung cancer tissue

Association between Parvovirus B19 and anemia in HIV-infected patients

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