Detecting Volume Responders prior to Implantation of a Cardiac Resynchronization Therapy Device via Minithoracotomy: The Septal Flash as a Predictor of Immediate Left Ventricular Reverse Remodeling

Čikeš, Maja; Bijnens, Bart; Đurić, Željko; Benčić, Martina Lovrić; Gošev, Igor; Velagić, Vedran; Gašparović, Hrvoje; Miličić, Davor; Biočina, Bojan

doi:10.1532/hsf98.20091129

Cited by 6 publications

(1 citation statement)

References 16 publications

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“…Septal flash has recently been a subject of thorough research in patients with heart failure, as it has been reported to be a mechanism to link conduction abnormalities and IVS dyssynchrony in HF [ 5 ]. According to the most recently published data, SF predicts CRT response in patients with permanent atrial fibrillation [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of septal flash and left ventricle contractile reserve on positive remodeling during 1 year cardiac resynchronization therapy: the multicenter ViaCRT study

Gąsior

Płońska‐Gościniak

Kułach

et al. 2016

aoms

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IntroductionCardiac resynchronization therapy (CRT) has been shown to improve outcomes in patients with systolic heart failure (HFREF). However, the relatively high non-responder rate results in a need for more precise qualification for CRT. The ViaCRT study was designed to determine the role of contractile reserve and dyssynchrony parameters in predicting CRT response. The purpose of this analysis was to determine the effect of baseline septal flash and contractile reserve (CR) on clinical and echocardiographic parameters of response to CRT in 12-month follow-up.Material and methodsOne hundred thirty-three guideline-selected CRT candidates (both ischemic and non-ischemic heart failure with reduced ejection fraction) were enrolled in the study. Baseline study population characteristics were: left ventricle ejection fraction (LVEF) 25 ±6%, QRS 165 ±25 ms, NYHA class III (90%) and IV (10%).ResultsIn subjects with septal flash (SF) registered before CRT implantation improvement in LVEF (14 ±2% vs. 8 ±1%, p < 0.05) and left ventricle (LV) systolic (63 ±10 ml vs. 36 ±6 ml, p < 0.05) and diastolic (46 ±10 ml vs. 32 ±7, p < 0.05) volumes was more pronounced than in patients without SF. In patients with CR (defined as LVEF increase by 20% or 4 viable segments) improvement in echo parameters was not significantly different then in the CR– group. Neither SF nor CR was associated with improvement in NYHA class. Subgroup analysis revealed that only in non-ischemic HF patients is presence of septal flash associated with LV function improvement after CRT.ConclusionsIn non-ischemic HF patients septal flash is a helpful parameter in prediction of LV remodeling after 12 months of resynchronization therapy.

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Section: Discussionmentioning

confidence: 99%

Impact of septal flash and left ventricle contractile reserve on positive remodeling during 1 year cardiac resynchronization therapy: the multicenter ViaCRT study

Gąsior

Płońska‐Gościniak

Kułach

et al. 2016

aoms

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Current role of echocardiography in cardiac resynchronization therapy

et al. 2017

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Heart Failure Reviews is an international journal which develops links between basic scientists and clinical investigators, creating a unique, interdisciplinary dialogue focused on heart failure, its pathogenesis and treatment. The journal accordingly publishes papers in both basic and clinical research fields. Topics covered include clinical and surgical approaches to therapy, basic pharmacology, biochemistry, molecular biology, pathology, and electrophysiology. The reviews are comprehensive, expanding the reader's knowledge base and awareness of current research and new findings in this rapidly growing field of cardiovascular medicine. All reviews are thoroughly peer-reviewed before publication.

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Combined Score Using Clinical, Electrocardiographic, and Echocardiographic Parameters to Predict Left Ventricular Remodeling in Patients Having Had Cardiac Resynchronization Therapy Six Months Earlier

Brunet-Bernard

Maréchaux

Fauchier

et al. 2014

The American Journal of Cardiology

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Detecting Volume Responders prior to Implantation of a Cardiac Resynchronization Therapy Device via Minithoracotomy: The Septal Flash as a Predictor of Immediate Left Ventricular Reverse Remodeling

Abstract: The preoperative presence of the septal flash is a valid predictor of the response to CRT. Immediately after CRT device activation, the septal flash disappears, and LV reverse remodeling and an increase in contractility are observed.

Cited by 6 publications

References 16 publications

Impact of septal flash and left ventricle contractile reserve on positive remodeling during 1 year cardiac resynchronization therapy: the multicenter ViaCRT study

Impact of septal flash and left ventricle contractile reserve on positive remodeling during 1 year cardiac resynchronization therapy: the multicenter ViaCRT study

Current role of echocardiography in cardiac resynchronization therapy

Combined Score Using Clinical, Electrocardiographic, and Echocardiographic Parameters to Predict Left Ventricular Remodeling in Patients Having Had Cardiac Resynchronization Therapy Six Months Earlier

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