Detecting ultrasonographic hollowness in small choroidal melanocytic tumors using 10 MHz and 20 MHz ultrasonography: a comparative study

Piñeiro-Ces, Antonio; Alvarez, María José Rodríguez; Santiago, Maria; Bande, Manuel Febrero; Pardo, María; Capeáns, C.; Blanco, Marı́a José

doi:10.1007/s00417-014-2758-4

Cited by 7 publications

(7 citation statements)

References 19 publications

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“…81 The risk factors include symptoms at the time of diagnosis of UM, acoustic shadow on ultrasound, nevus height > 1.5 mm, and a basal diameter > 8 mm. 82 The mean serum level of this group of patients was 89.56 ng/mL compared to 37.39 ng/mL for the nevus group without associated risk factors and 32.98 ng/mL for the control group. 83 This indicates that DJ-1 could be a potential marker of malignant transformation of choroid nevi.…”

Section: Proteins Identified From Um Cells Cultured In Vitromentioning

confidence: 66%

<p>Blood Biomarkers of Uveal Melanoma: Current Perspectives</p>

Rodríguez

Marta

Baameiro

et al. 2020

OPTH

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The detection of metastases in patients with a diagnosis of uveal melanoma (UM) is a controversial issue. While only 1% of the patients have detectable metastases at the time of diagnosis, up to 30% of them will develop liver metastases within 5 years of treatment. UM spreads hematogenously, therefore, blood biomarkers may be helpful for prognosis and monitoring the disease progression. Despite the great progress achieved thanks to the genetic analysis of UM biopsies, this is an invasive technique and is limited by the heterogeneity of the tumor. The present review considers the current understanding in the field regarding biomarkers for the diagnosis and prognosis of UM and its metastasis, primarily to the liver. General covered topics include non-conventional markers such as proteins previously identified in cutaneous melanoma and UM cell lines, circulating tumor cells, microRNAs (miRNA), and circulating DNA, and how each may be critical in the development of novel blood biomarkers for UM.

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Section: Proteins Identified From Um Cells Cultured In Vitromentioning

confidence: 66%

<p>Blood Biomarkers of Uveal Melanoma: Current Perspectives</p>

Rodríguez

Marta

Baameiro

et al. 2020

OPTH

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“…In these nine cases, thickness was assumed not to exceed 0.5 mm. 26 In the DFUM group of patients, eight patients were treated with brachytherapy using I-125 and three patients by primary enucleation. These patients were treated at a minimum of 10 years before blood collection.…”

Section: Methods Patientsmentioning

confidence: 99%

ME20-S as a Potential Biomarker for the Evaluation of Uveal Melanoma

Bande

Santiago

Mera

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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“…Precise lesion description is essential in humans as small choroidal melanomas may mimic benign nevi on fundoscopy. Options for lesion evaluation include ocular ultrasound 17 , computed tomography, and MRI. 1 Additionally, advanced retinal imaging including optical coherence tomography and various methods of angiography are used for this purpose 18 A mnemonic exists to help with differentiation of choroidal melanomas from nevi in physician-based medicine: TFSOM-UHHD (To Find Small Ocular Melanoma Using Helpful Hints Daily).…”

Section: This Is a Case Of Particularly Aggressive Local Invasion Of ...mentioning

confidence: 99%

Unilateral invasive intraocular melanoma with choroidal and optic nerve involvement resulting in bilateral vision loss in a Labrador Retriever

Opgenorth

Gibson

Mamaliger

et al. 2023

Veterinary Ophthalmology

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A 10-year-old male castrated Labrador Retriever cross was referred for evaluation of acute vision loss. Ophthalmic examination revealed mild left sided exophthalmos, bilateral resting mydriasis, an absent direct and reduced consensual PLR in the left eye and reduced direct and absent consensual PLR in the right eye.Examination of the cornea and anterior segment with slit lamp biomicroscopy was unremarkable. Indirect fundoscopy revealed a left optic nerve head obscured by a darkly pigmented lesion. Fundic examination in the right eye was unremarkable. Magnetic resonance imaging revealed a smoothly marginated, lobulated cone to irregularly shaped, strongly T1 hyperintense, T2 and T2 fluid-attenuated inversion recovery hypointense, strongly contrast enhancing mass closely associated with the entire left optic nerve, extending across the optic chiasm and into the right optic nerve ventrally. Full clinical staging revealed no evidence of metastasis. Exenteration of the left eye was performed. Histopathology revealed an unencapsulated, poorly demarcated, multilobulated and infiltrative pigmented mass that was effacing the posterior choroid and optic nerve. The mass was composed of a moderately pleomorphic population of heavily pigmented polygonal cells arranged in sheets and clusters, displaying moderate anisocytosis and anisokaryosis. The population of cells contained moderate amounts of abundant brown-black granular pigment consistent with melanin within the cytoplasm. Mitotic figures averaged approximately three per ten 400× fields (2.37 mm 2 ). This is the first report of a melanocytic tumor invading along the optic nerve and tract to result in contralateral vision loss.

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Detecting ultrasonographic hollowness in small choroidal melanocytic tumors using 10 MHz and 20 MHz ultrasonography: a comparative study

Abstract: UH is easier to detect by 20 MHz than by 10 MHz ultrasonography. This ultrasonographic sign appears to be correlated with the height of the tumor. Thus, we believe UH estimation by 20 MHz ultrasonography could be used as a significant predictive factor for SCMT growth.

Cited by 7 publications

References 19 publications

<p>Blood Biomarkers of Uveal Melanoma: Current Perspectives</p>

<p>Blood Biomarkers of Uveal Melanoma: Current Perspectives</p>

ME20-S as a Potential Biomarker for the Evaluation of Uveal Melanoma

Unilateral invasive intraocular melanoma with choroidal and optic nerve involvement resulting in bilateral vision loss in a Labrador Retriever

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