Abstract:The regulation of biochemical pathways is controlled at a variety of levels, from transcriptional timing to protein localization. Here we study the corticosteroid synthesis pathway in order to understand a transition from a biochemical pathway controlled by allosteric regulation to a phenotypically equivalent pathway controlled by differential expression of paralogs and enzyme specificity.The corticosteroids aldosterone and cortisol are produced in different layers of the adrenal cortex – a phenomenon known as… Show more
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