Detecting Pathological Complete Response in Esophageal Cancer after Neoadjuvant Therapy Based on Imaging Techniques: A Diagnostic Systematic Review and Meta-Analysis

Gouw, D.J.J.M. de; Klarenbeek, Bastiaan; Driessen, M.L.S.; Bouwense, Stefan; Workum, Frans van; Fütterer, Jurgen J.; Rovers, Maroeska M.; Broek, Richard P. G. ten; Rosman, Camiel

doi:10.1016/j.jtho.2019.04.004

Cited by 99 publications

(86 citation statements)

References 77 publications

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“…2 Neoadjuvant therapy with chemotherapy or chemoradiotherapy has supplemented surgery as the standard treatment of ESCA, and surgery has become more standardized and centralized. 3 Developing a robust prognostic predictor for patients with ESCA is critical for precise individualized treatment. The Tumor, Node, Metastasis (TNM) staging system is currently the most commonly used indicator for ESCA staging and prognostic prediction.…”

Section: Introductionmentioning

confidence: 99%

Construction and Validation of an m6A RNA Methylation Regulators-Based Prognostic Signature for Esophageal Cancer

Xu¹,

Pan²,

Pan³

2020

CMAR

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N6-methyladenosine (m6A) is reported to play a critical role in cancer through various mechanisms. We aimed to construct and validate an m6A RNA methylation regulators-based prognostic signature for Esophageal cancer (ESCA). Materials and Methods: The RNA sequencing transcriptome data of 13 m6A RNA methylation regulators as well as clinical data were obtained from The Cancer Genome Atlas (TCGA) ESCA database. The differential expression of the regulators between ESCA tissues and normal tissues was assessed. Consensus clustering was conducted to explore the different ESCA clusters based on the expression of these regulators. LASSO Cox regression analysis was used to generate a prognostic signature based on m6A RNA methylation regulators expression. Results: Eight regulators (KIAA1429, HNRNPC, RBM15, METTL3, WTAP, YTHDF1, YTHDC1, and YTHDF2) were found to be significantly upregulated in ESCA tissues. Significant differences of survival rate and clinicopathological features were found between the two clusters. A prognostic signature, which consists of HNRNPC and ALKBH5, was constructed based on the TCGA ESCA cohort, which can serve as an independent prognostic predictor. The results of bioinformatics analysis were further successfully validated in the clinical ESCA cohort by qRT-PCR and immunohistochemistry staining. Conclusion: Our study constructed and validated an m6A RNA methylation regulatorsbased prognostic signature. This might provide important information for developing diagnostic and therapeutic strategies.

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Section: Introductionmentioning

confidence: 99%

Construction and Validation of an m6A RNA Methylation Regulators-Based Prognostic Signature for Esophageal Cancer

Xu¹,

Pan²,

Pan³

2020

CMAR

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“…Esophageal cancer (ECa) is one of the alimentary tract malignancies with high morbidity and mortality. Currently, it ranks 9 th in the global cancer incidence and 6 th in the total mortality 1–3. In developed countries, the incidence of ECa ranks 20th, but its death ranks 11 th 4,5.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-186-5p Inhibits Proliferation And Metastasis Of Esophageal Cancer By Mediating HOXA9

Xu¹,

Li²,

Zhao³

et al. 2019

OTT

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ObjectiveMicroRNA (miRNA) is an endogenous, non-coding small RNA that plays a key role in regulating organism biology and pathology. The aim of this study was to investigate the expression characteristics of microRNA-186-5p in esophageal cancer (ECa) and its correlation with clinical progression and prognosis, and to further explore its underlying mechanisms.MethodsReal-time quantitative PCR (qRT-PCR) was used to detect microRNA-186-5p level in 45 pairs of ECa tissue samples and adjacent ones, and to analyze the expression of microRNA-186-5p and clinical progression of ECa and prognosis. The relationship between microRNA-186-5p level in ECa cell lines was further verified by qRT-PCR. Finally, the potential mechanism was explored using luciferase reporter gene assay and cell recovery experiment.ResultsQRT-PCR results revealed that the expression of microRNA-186-5p in ECa tissues was remarkably lower than that in adjacent tissues, and the difference was statistically significant. Compared with patients with high expression of microRNA-186-5p, patients with low expression of microRNA-186-5p had higher incidence of pathological stage and lower overall survival rate. Besides, compared with the miR-NC group, the microRNA-186-5p mimics group had a significant decrease in proliferation and metastasis ability of ECa cells. Subsequent qRT-PCR validation in ECa cell lines and tissues indicated a significant increase in HOXA9 expression and a negative correlation with microRNA-186-5p.ConclusionThe expression of microRNA-186-5p was remarkably decreased in ECa, which was remarkably correlated with pathological stage, distant metastasis and poor prognosis of ECa. The results suggested that microRNA-186-5p may inhibit cell proliferation of ECa by regulating HOXA9.

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“… 6 The accuracy to detect locoregional lymph node metastases after nCRT is only low to moderate with positron emission tomography (PET)–computed tomography (CT) or endoscopic ultrasound. 7 With on average only 31% to 38% of patients who have lymph node metastases after nCRT, 6 the international guidelines still recommend lymph node dissection in all patients, 8 , 9 resulting in overtreatment of this patient population.…”

Section: Why Are Lymph Nodes Important For Oncologic Staging?mentioning

confidence: 99%

The Role of Magnetic Resonance Imaging in (Future) Cancer Staging

Scheenen¹,

Zámecnik

2021

Invest Radiol

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Detecting Pathological Complete Response in Esophageal Cancer after Neoadjuvant Therapy Based on Imaging Techniques: A Diagnostic Systematic Review and Meta-Analysis

Cited by 99 publications

References 77 publications

<p>Construction and Validation of an m6A RNA Methylation Regulators-Based Prognostic Signature for Esophageal Cancer</p>

<p>Construction and Validation of an m6A RNA Methylation Regulators-Based Prognostic Signature for Esophageal Cancer</p>

<p>MicroRNA-186-5p Inhibits Proliferation And Metastasis Of Esophageal Cancer By Mediating HOXA9</p>

The Role of Magnetic Resonance Imaging in (Future) Cancer Staging

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